CATH Domain: 2d0nA00 XML data for domain: 2d0nA00

Molscript image for 2d0nA00
2d0nA00
PDB coordinates for domain 2d0nA00

PDB 2d0n, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.6
2.30.30.40.6.2
2.30.30.40.6.2.1
2.30.30.40.6.2.1.1
2.30.30.40.6.2.1.1.1

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Segment boundaries for domain 2d0nA00

Chopping figure for domain 2d0nA00
DomainStart PDB ResidueStop PDB Residue
2d0nA00 264 322

Structural Neighbourhood (78 entries)

There are 78 matching structural neighberhood comparisons for CATH ID 2.30.30.40.6.2.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 78 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vwfA00 94.41 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 44 94 0.66 0.70
1ckaA00 93.37 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 32 94 1.04 1.10
3i35A00 93.29 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 35 94 1.19 1.25
3i9qA00 93.00 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 26 96 1.07 1.11
1jo8A00 92.97 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 34 94 1.02 1.08
1sshA00 92.94 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion 2.30.30.40 60 39 96 2.53 2.62
1w70A00 92.93 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 29 96 1.30 1.34
1ov3A02 92.83 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 22 93 1.15 1.24
1yn8A00 92.47 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 32 94 1.24 1.31
2v1qA00 92.45 Actin cortical patch assemblyMating projection tipIdentical protein bindingNucleusActin filament organization 2.30.30.40 60 27 95 1.05 1.11
2j6fA00 92.37 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 28 94 1.36 1.43
3ehrB01 92.28 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 89 91 1.46 1.59
2ak5B00 92.27 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 44 90 1.55 1.71
1zuyA00 91.53 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 31 94 1.39 1.47
3h0hA00 91.36 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 44 92 1.85 2.01
3eg3A00 91.20 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 62 22 91 2.58 2.81
2rqtA00 91.10 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 31 91 1.35 1.47
1griA01 90.84 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 39 82 0.82 0.99
2csqA01 90.69 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 36 86 1.50 1.74
2jteA00 90.65 Mus musculusCD2-associated protein 2.30.30.40 64 32 90 1.43 1.58
2vknA00 90.64 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 32 86 1.12 1.30
1ad5A01 90.50 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 36 88 1.44 1.62
2ablA01 89.90 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 24 87 2.61 2.97
1ycsB02 89.87 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 29 90 2.32 2.56
2v1rA00 89.84 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 34 86 1.48 1.71
1jegA00 89.43 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 34 95 1.62 1.71
1wx6A01 89.41 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 34 87 1.52 1.73
1x6bA01 89.29 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 18 87 1.30 1.49
1ng2A02 89.18 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 20 83 1.55 1.85
1uhfA00 88.87 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 34 82 1.94 2.35
2js2A00 88.51 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 25 90 3.02 3.34
1gcqC00 88.48 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 24 84 1.90 2.26
1awwA00 87.73 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 36 86 1.48 1.71
1j3tA00 87.50 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 27 77 1.56 2.03
2epdA00 87.47 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 31 76 1.24 1.62
1ng2A01 86.51 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 22 75 1.71 2.25
1spkA00 86.32 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 17 80 2.02 2.51
3i5rA00 86.08 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 24 71 1.68 2.35
2ke9A00 85.82 Caskin-2Homo sapiens 2.30.30.40 67 27 85 1.95 2.29
1bb9A00 85.19 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 22 69 1.90 2.72
1u3oA01 85.03 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 18 88 2.10 2.37
1tucA00 84.38 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 61 22 72 3.52 4.88
1jxmA01 83.77 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 25 66 2.26 3.41
2heqA01 83.58 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 5 87 2.90 3.30
1sf9A02 83.48 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 11 75 2.28 3.01
1igqB00 83.01 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 3 74 2.43 3.28
1udlA00 82.62 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 98 37 59 1.28 2.16
2hbwA01 82.51 Anabaena variabilis ATCC 29413NLP/P60 2.30.30.40 72 8 76 2.80 3.67
1uffA00 82.27 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 37 62 2.01 3.22
1mhnA00 82.05 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 5 83 3.16 3.80
1i1jB00 81.86 Melanoma-derived growth regulatory proteinHomo sapiensExtracellular spaceCell proliferation 2.30.30.40 103 24 56 1.53 2.72
2rh2A00 81.71 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 10 79 2.87 3.62
2g3rA01 81.39 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 7 82 3.27 3.95
2aklA02 81.02 Phosphonate and phosphinate metabolismPseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Putative uncharacterized protein 2.30.30.40 73 8 78 3.50 4.48
1mmdA01 80.86 ActomyosinMyosin II complexActin-myosin filament slidingProtein localizationActin filament binding 2.30.30.360 48 2 79 3.74 4.72
2o2oA00 80.78 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 31 77 2.26 2.92
1dj7B00 80.44 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 6 79 3.95 4.97
1ug1A00 80.32 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 20 63 2.38 3.78
1khcA01 79.67 Protein complex localizationRegulation of gene expression by genetic imprintingDNA (cytosine-5)-methyltransferase 3BChromosome, centromeric regionProtein binding 2.30.30.160 65 5 73 3.42 4.63
1jb0E00 79.58 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 6 72 2.71 3.74
1m9sA05 79.41 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 78 5 74 3.15 4.24
1ib8A02 79.08 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 6 76 3.23 4.24
1biaA03 78.91 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 2 81 3.55 4.38
1ri9A00 78.57 FYN-binding proteinProtein phosphorylationNucleusHomo sapiensImmune response 2.30.30.40 77 10 74 2.55 3.44
1m9sA04 77.94 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 86 13 67 3.08 4.57
1vytA01 77.57 Cardiac muscle contractionRattus norvegicusDilated cardiomyopathyVoltage-gated calcium channel complexCalcium channel, voltage-dependent, beta 3 subunit 2.30.30.40 108 20 53 1.70 3.17
1irxA02 77.04 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 9 72 2.83 3.91
1awjA00 76.92 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 29 75 3.68 4.89
1u1sA00 76.84 RNA degradationPseudomonas aeruginosaHost factor-I proteinProtein hfq 2.30.30.100 66 3 65 2.64 4.05
1kq1H00 76.65 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 12 65 2.58 3.96
2k57A00 76.61 Pseudomonas syringae pv. phaseolicola 1448ALipoprotein, putative 2.30.30.100 55 10 75 3.79 5.00
2ra2B00 76.10 Salmonella enterica subsp. enterica serovar TyphimuriumPutative lipoprotein 2.30.30.100 55 16 68 2.97 4.31
2hqxA01 75.15 Staphylococcal nuclease domain-containing protein 1NucleusGolgi apparatusTranscription cofactor activityHomo sapiens 2.30.30.140 81 8 59 2.68 4.52
1d3bC00 73.16 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D3Small nuclear ribonucleoprotein D3Spliceosomal complex 2.30.30.100 71 5 61 3.05 4.92
1b34A00 73.13 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D1RNA bindingProtein binding 2.30.30.100 80 10 55 2.39 4.35
3by7E00 72.77 2.30.30.100 74 10 56 2.79 4.92
1b34B00 72.57 SpliceosomeSpliceosomal complexSmall nuclear ribonucleoprotein Sm D2Homo sapiensSmall nuclear ribonucleoprotein D2 2.30.30.100 74 3 59 2.90 4.88
1ljoA00 71.05 Archaeoglobus fulgidusSnRNP, putative 2.30.30.100 75 10 60 2.95 4.92
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Displaying entries 1 to 78 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2d0nA00
GSPWARALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMMR
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2d0nA00
GSPWARALYDFEALEEDELGFRSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMMR
BLAST against CATH

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Domain History Events (5)

Domain assigned by auto on 28 Apr 2006 21:39

Assigning to "2.30.30.40" based on similarity with "2d0nC00" (NWSI: 100, NWO: 100, SPS: 96.63, SPO: 94, RMSD: 0.81)

Flow stage update by auto on 28 Apr 2006 17:51

NW result present for Domain "2d0nA00"

Flow stage update by auto on 28 Apr 2006 17:48

All required files are present for Domain "2d0nA00"

Flow stage update by auto on 27 Apr 2006 17:32

Beginning processing for Domain "2d0nA00"

Insertion by auto on 10 Mar 2006 17:52

Final ChopClose added based on similarity with "1utiA" [LEE: 1, LME: 0, MR: 0, LG: 1, SS: 96.07, SI: 96.551724137931, SO: 98.3050847457627]