CATH Domain: 2cm2A00

2cm2A00

PDB 2cm2, Chain A, Domain 0

CATH Code	Level Description	Links
3	Alpha Beta
3.90	Alpha-Beta Complex
3.90.190	Protein-Tyrosine Phosphatase; Chain A
3.90.190.10	Protein tyrosine phosphatase superfamily	Gene3D
3.90.190.10.5
3.90.190.10.5.1
3.90.190.10.5.1.1
3.90.190.10.5.1.1.1
3.90.190.10.5.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 2cm2A00

Domain	Start PDB Residue	Stop PDB Residue
2cm2A00	0	283

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (5 entries)

There are 5 matching structural neighberhood comparisons for CATH ID 3.90.190.10.5.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
2ooqA00	90.99	Cell surfaceDelta-catenin bindingPlasma membraneHomophilic cell adhesionReceptor-type tyrosine-protein phosphatase T	3.90.190.10	276	34	93	1.86	1.98
2i1yA00	90.57	Protein tyrosine phosphatase, receptor type, N [EC:3.1.3.48]Transmembrane receptor protein tyrosine phosphatase activityType I diabetes mellitusIntegral to plasma membraneHomo sapiens	3.90.190.10	285	35	94	1.82	1.92
1p15B00	87.58	Mus musculusProtein phosphorylationReceptor-type tyrosine-protein phosphatase alphaInsulin receptor signaling pathway	3.90.190.10	246	34	85	1.89	2.21
2cjzA00	87.40	Protein dephosphorylationTyrosine-protein phosphatase non-receptor type 5Protein tyrosine phosphatase activityHomo sapiensPhosphotyrosine binding	3.90.190.10	275	27	89	2.41	2.69
1g4wR02	81.17	Salmonella enterica subsp. enterica serovar TyphimuriumSecreted effector protein sptPSecreted effector protein SptPProtein binding	3.90.190.10	221	14	73	2.38	3.22

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Domain ATOM Sequence

>pdb|2cm2A00
HHEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQR
SYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLE
LENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRK
DPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMG

BLAST against CATH

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Domain COMBS Sequence

>pdb|2cm2A00
MHHHHHHEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKM
EEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYT
VRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLL
MDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED

BLAST against CATH

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Domain History Events (11)

Domain assigned by auto on 01 Nov 2006 18:35

Assigning to "3.90.190.10" based on similarity with "2cmaA00"