CATH Domain: 2c0gA01

2c0gA01

PDB 2c0g, Chain A, Domain 1

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.30	Glutaredoxin
3.40.30.10	Glutaredoxin	Gene3D
3.40.30.10.19
3.40.30.10.19.1
3.40.30.10.19.1.1
3.40.30.10.19.1.1.1
3.40.30.10.19.1.1.1.1

Structure
Sequence
History

[top]
Segment boundaries for domain 2c0gA01

Domain	Start PDB Residue	Stop PDB Residue
2c0gA01	1024	1145
2c0gA02	1146	1251

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (22 entries)

There are 22 matching structural neighberhood comparisons for CATH ID 3.40.30.10.19.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
2b5eA01	87.92	Protein disulfide isomerase activityProtein disulfide oxidoreductase activityProtein bindingProtein foldingEndoplasmic reticulum lumen	3.40.30.10	119	13	87	1.98	2.26
2dizA00	85.96	Anti-apoptosisHomo sapiensThioredoxin domain-containing protein 5	3.40.30.10	117	18	89	3.42	3.83
2pu9C00	85.38	Thioredoxin F-type, chloroplasticSpinacia oleraceaProtein binding	3.40.30.10	111	12	84	2.67	3.16
1thxA00	85.21	Nostoc sp. PCC 7120Thioredoxin-2	3.40.30.10	108	16	85	2.57	3.01
2e0qA00	85.18	Sulfolobus tokodaii140aa long hypothetical thioredoxinThioredoxin 1	3.40.30.10	104	15	82	2.34	2.83
1gh2A00	84.49	CytoplasmHomo sapiensThioredoxin-like protein 1Disulfide oxidoreductase activity	3.40.30.10	107	14	82	2.19	2.65
3gnjA00	84.24	Desulfitobacterium hafniense DCB-2Thioredoxin domain protein	3.40.30.10	107	19	84	2.53	3.00
2b5eA04	83.99	Endoplasmic reticulum lumenProtein disulfide oxidoreductase activityProtein disulfide isomerase activityProlyl 4-hydroxylase, beta polypeptide [EC:5.3.4.1]Saccharomyces cerevisiae	3.40.30.10	140	17	79	2.47	3.12
1a8yA02	83.62	Calsequestrin-1Oryctolagus cuniculus	3.40.30.10	102	12	80	2.44	3.04
1mekA00	83.49	Cell surfaceER-Golgi intermediate compartmentProtein disulfide isomerase activityProtein bindingPeptidyl-proline hydroxylation to 4-hydroxy-L-proline	3.40.30.10	120	12	89	2.61	2.92
1bjxA00	83.31	Cell surfaceProtein disulfide isomerase activityER-Golgi intermediate compartmentProtein bindingPeptidyl-proline hydroxylation to 4-hydroxy-L-proline	3.40.30.10	110	18	83	3.78	4.52
1w4vA00	82.82	Thioredoxin, mitochondrialHomo sapiensThioredoxin 1	3.40.30.10	110	18	86	2.76	3.18
1a8yA01	82.32	Calsequestrin-1Oryctolagus cuniculus	3.40.30.10	124	9	87	3.33	3.79
1g7eA00	81.84	Rattus norvegicusEndoplasmic reticulum lumenEndoplasmic reticulum protein 29Transport vesicleEndoplasmic reticulum resident protein 29	3.40.30.10	122	28	97	3.45	3.54
1sjiA03	80.95	Canis lupus familiarisCalsequestrin-2	3.40.30.10	123	16	91	3.33	3.66
1v98A00	80.84	Thermus thermophilus HB8Thioredoxin 2 [EC:1.8.1.8]Thioredoxin	3.40.30.10	92	16	72	3.05	4.18
2trcP01	79.40	PhosducinRattus norvegicus	3.40.30.10	131	11	80	3.49	4.31
2f51A00	79.22	Trichomonas vaginalisThioredoxin 1Thioredoxin	3.40.30.10	101	18	77	3.24	4.16
2kucA00	77.59	Bacteroides thetaiotaomicronPutative disulphide-isomerase	3.40.30.10	121	12	93	4.35	4.66
2in3A01	75.56	Nitrosomonas europaeaPutative protein-disulfide isomerasePutative uncharacterized protein	3.40.30.10	78	6	60	2.86	4.72
2qsiA01	75.50	Putative hydrogenase expression/formation protein hupGHydrogenase-1 operon protein HyaERhodopseudomonas palustris	3.40.30.10	82	15	65	2.92	4.45
1ttzA00	75.15	Xanthomonas campestris pv. campestrisPutative uncharacterized protein	3.40.30.10	74	16	59	2.81	4.76

[top]
Domain ATOM Sequence

>pdb|2c0gA01
CTGCVDLDELSFEKTVERFPYSVVKFDIASPYGEKHEAFTAFSKSAHKATKDLLIATVGVKDYGELENKALGDRYKVDDK
NFPSIFLFKGNADEYVQLPSHVDVTLDNLKAFVSANTPLYIG

BLAST against CATH

[top]
Domain COMBS Sequence

>pdb|2c0gA01
MRGSHHHHHHGSVTCTGCVDLDELSFEKTVERFPYSVVKFDIASPYGEKHEAFTAFSKSAHKATKDLLIATVGVKDYGEL
ENKALGDRYKVDDKNFPSIFLFKGNADEYVQLPSHVDVTLDNLKAFVSANTPLYIG

BLAST against CATH

[top]
Domain History Events (14)

Domain assigned by auto on 02 Nov 2006 06:21

Assigning to "3.40.30.10" based on similarity with "2c0gB01"

Flow stage update by auto on 02 Nov 2006 06:12

No in_process hits for Domain "2c0gA01" ready to be processed

Update comment by auto on 02 Nov 2006 03:17

Domain "2c0gA01" hits Domain "2c0gB01" (100% over 100%) which is currently in process

Update comment by auto on 01 Nov 2006 21:56

Domain "2c0gA01" hits Domain "2c0eA01" (98.4251968503937% over 93.3823529411765%) which is currently in process