CATH Domain: 2basA02

2basA02

PDB 2bas, Chain A, Domain 2

CATH Code	Level Description	Links
1	Mainly Alpha
1.20	Up-down Bundle
1.20.5	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
1.20.5.170		Gene3D
1.20.5.170.15
1.20.5.170.15.1
1.20.5.170.15.1.1
1.20.5.170.15.1.1.1
1.20.5.170.15.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 2basA02

Domain	Start PDB Residue	Stop PDB Residue
2basA01	2	229
2basA02	246	291
2basA03	292	407

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (74 entries)

There are 74 matching structural neighberhood comparisons for CATH ID 1.20.5.170.15.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
3e7kA00	88.14	Rattus norvegicusCalcium channel activityCalcium ion transportIntegral to membraneProtein binding	1.20.5.1010	54	8	77	1.57	2.02
1n2dC00	87.98	Mating projection tipGolgi inheritanceActin filament bindingVesicle-mediated transportMyosin-2	1.20.5.190	48	8	81	1.37	1.69
2ifoA00	87.29	Xanthomonas phage XfCapsid protein G8P	1.20.5.230	46	2	89	1.94	2.18
1g2cB00	87.09	Human respiratory syncytial virus strain RSS-2Fusion glycoprotein F0	1.20.5.170	40	5	80	2.17	2.70
1lghB00	86.84	Phaeospirillum molischianumLight-harvesting protein B-800/850 beta 1 chain	1.20.5.250	43	9	89	4.41	4.95
1svfC00	85.95	Simian virus 5 (strain W3)Fusion glycoprotein F0	1.20.5.300	62	6	74	1.79	2.41
1ezjA02	85.80	Sendai virus (strain Harris)Phosphoprotein	1.10.287.340	52	10	71	1.31	1.84
1tiiC00	85.77	Heat-labile enterotoxin IIB, A chainEscherichia coli	1.20.5.200	36	5	73	1.44	1.95
3ii6A02	85.69	DNA ligation involved in DNA repairProtein C-terminus bindingDNA-dependent protein kinase-DNA ligase 4 complexResponse to X-rayDouble-strand break repair via nonhomologous end joining	1.20.5.370	58	8	77	1.70	2.19
1gmjD00	85.23	Negative regulation of hydrolase activityProtein homodimerization activityATPase inhibitor activityBos taurusCalmodulin binding	1.20.5.500	56	4	73	1.82	2.49
2zxeB01	84.68		1.20.5.170	35	8	76	2.15	2.83
1l2pA00	84.41	Oxidative phosphorylationMetabolic pathwaysATP synthesis coupled proton transportAnchored to membraneF-type H+-transporting ATPase subunit b [EC:3.6.3.14]	1.20.5.620	61	13	75	2.23	2.96
1jekA00	84.31	Visna/maedi virus EV1 KV1772Envelope glycoprotein gp160	1.20.5.440	40	5	78	2.88	3.68
1piqA00	84.26	NucleusPositive regulation of RNA polymerase II transcriptional preinitiation complex assemblyGeneral control protein GCN4General control protein GCN4Specific RNA polymerase II transcription factor activity	1.20.5.170	31	9	67	1.52	2.26
3gwoA00	84.15	Human immunodeficiency virus type 1 lw12.3 isolateEnvelope glycoprotein gp160	1.10.287.210	53	6	84	2.61	3.07
2w83C00	83.83	Homo sapiensIntegral to membraneC-Jun-amino-terminal kinase-interacting protein 4SpermatogenesisPositive regulation of cell migration	1.20.5.1000	67	2	68	1.47	2.14
2k1aA00	83.77	Integrin alpha 2BIdentical protein bindingPathways in cancerHematopoietic cell lineageDilated cardiomyopathy	1.20.5.930	42	7	91	3.78	4.14
1r8eA03	83.74	Multidrug-efflux transporter 1 regulatorBacillus subtilis	1.20.5.490	44	4	71	1.92	2.68
2qjyC01	83.70	Oxidative phosphorylationMetabolic pathwaysRhodobacter sphaeroidesUbiquinol-cytochrome c reductase iron-sulfur subunitUbiquinol-cytochrome c reductase iron-sulfur subunit [EC:1.10.2.2]	1.20.5.510	33	3	69	1.41	2.03
1pfiA00	83.62	Pseudomonas phage Pf1Capsid protein G8P	1.20.5.230	46	8	95	3.68	3.85
1ltsC00	83.47	Heat-labile enterotoxin A chainEscherichia coli	1.20.5.240	41	7	67	1.87	2.77
3efgA00	83.46	Xanthomonas campestris pv. campestrisSlyX proteinProtein slyX homolog	1.20.5.300	49	17	91	3.51	3.82
1jmmA01	83.46	Major cell-surface adhesin PAcStreptococcus mutans	1.20.5.250	32	0	69	1.55	2.23
1u57A00	83.01	Human immunodeficiency virus type 1 lw12.3 isolateGag polyprotein	1.20.5.760	48	8	79	2.02	2.55
1omiA02	82.89	Listeria monocytogenesListeriolysin regulatory protein	1.20.5.460	27	7	58	0.83	1.41
1hj0A00	82.78	Bos taurusThymosin beta-10	1.20.5.520	41	2	82	3.94	4.77
3kpeA00	82.68	Fusion glycoprotein F0Human respiratory syncytial virus A2	1.20.5.300	47	8	63	1.79	2.80
1m7lA00	82.29	Negative regulation of T cell proliferationProtein bindingInnate immune responseLung alveolus developmentEndocytic vesicle	1.20.5.360	40	2	82	3.31	4.01
3effK02	82.17	Streptomyces lividansVoltage-gated potassium channel	1.20.5.440	45	8	65	1.63	2.50
1ik7A00	82.00	Regulation of proteolysisProtein domain specific bindingHemocyte proliferationPlasma membraneZygotic specification of dorsal/ventral axis	1.20.5.530	52	10	63	1.71	2.69
1nknA00	81.89	NucleusPositive regulation of RNA polymerase II transcriptional preinitiation complex assemblyGeneral control protein GCN4General control protein GCN4Positive regulation of gene-specific transcription from RNA polymerase II promoter	1.20.5.340	74	6	62	1.55	2.49
1dh3A00	81.63	Positive regulation of multicellular organism growthLactationRegulation of cell sizeAxonogenesisMus musculus	1.20.5.170	55	6	63	1.60	2.51
1go9A00	81.55		1.20.5.480	39	7	84	3.14	3.70
1wt6B00	81.35	ATP bindingProtein phosphorylationRegulation of heart contractionHomo sapiensProtein serine/threonine kinase activity	1.20.5.340	67	0	68	2.57	3.74
2hr3A01	81.14	Probable transcriptional regulatorPseudomonas aeruginosa	1.20.5.420	30	16	63	1.42	2.25
1kilE00	80.65	Complexin-1Syntaxin-1 bindingRattus norvegicusDendriteSynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex	1.20.5.580	41	4	73	3.26	4.41
1g4yB00	80.33	Rattus norvegicusSmall conductance calcium-activated potassium channel protein 2Small conductance calcium-activated potassium channel activityIntegral to membranePotassium ion transport	1.10.287.70	81	4	55	1.73	3.11
1qexA01	80.24	Enterobacteria phage T4Baseplate structural protein Gp9	1.20.5.960	35	0	58	2.08	3.54
1ifpA00	80.02	Pseudomonas phage Pf3Capsid protein G8P	1.20.5.440	44	6	58	1.30	2.21
1gk4C00	80.01	Cellular component movementProtein C-terminus bindingIntermediate filamentVimentinCytosol	1.20.5.170	70	13	64	2.07	3.22
1s3jB01	79.74	Bacillus subtilisUncharacterized HTH-type transcriptional regulator yusO	1.20.5.420	30	10	65	2.11	3.24
1ic2B00	79.73	Gallus gallusTropomyosin alpha-1 chain	1.20.5.340	77	10	53	1.75	3.29
2dw3A01	79.40	Intrinsic membrane protein pufXRhodobacter sphaeroides 2.4.1	1.20.5.920	55	6	83	3.54	4.23
1uixA00	79.39	Chemokine signaling pathwayRho-associated, coiled-coil containing protein kinase [EC:2.7.11.1]Leukocyte transendothelial migrationWnt signaling pathwayTGF-beta signaling pathway	1.20.5.730	68	6	48	1.09	2.25
1s5lX00	79.25	Photosystem II reaction center X proteinThermosynechococcus elongatus BP-1	1.20.5.510	40	10	58	2.72	4.63
1kqfB03	79.01	Two-component systemMetabolic pathwaysGlyoxylate and dicarboxylate metabolismMethane metabolismFormate dehydrogenase activity	1.20.5.480	44	2	65	2.19	3.36
2b9bA04	77.99	Simian virus 5 (strain W3)Fusion glycoprotein F0	1.20.5.1070	62	0	51	1.74	3.37
2p10B02	77.66	Mesorhizobium lotiMll9387 protein	1.20.5.460	26	7	52	1.61	3.09
1ybkA00	77.40	TetrabrachionStaphylothermus marinus	1.20.5.1060	52	6	55	2.39	4.29
2p7jB01	77.26	Vibrio parahaemolyticusPutative sensory box/GGDEF family protein	1.20.5.170	39	10	54	1.92	3.53
1ozhA03	77.09	Acetolactate synthase, catabolicKlebsiella pneumoniae	1.20.5.740	24	12	52	2.03	3.89
1fdoA05	76.92	Methane metabolismMetabolic pathwaysGlyoxylate and dicarboxylate metabolismFormate dehydrogenase HFormate dehydrogenase, alpha subunit [EC:1.2.1.2]	1.20.5.460	27	7	52	1.80	3.45
1junA00	76.88	Pathways in cancerChagas diseaseNeurotrophin signaling pathwayB cell receptor signaling pathwayT cell receptor signaling pathway	1.20.5.170	43	4	63	2.97	4.71
1h8bB00	76.07	TitinOryctolagus cuniculus	1.20.5.510	23	17	47	1.56	3.26
1kv4A00	75.92	Moricin-1Bombyx mori	1.20.5.750	42	7	52	2.29	4.39
1be3K00	75.77	Cardiac muscle contractionCytochrome b-c1 complex subunit 10Oxidative phosphorylationParkinson's diseaseAlzheimer's disease	1.20.5.220	22	4	47	1.54	3.22
1qbzA00	75.37	Simian immunodeficiency virusEnvelope glycoprotein	1.10.287.210	102	6	45	1.82	4.04
2wpqA00	75.29	Salmonella enterica subsp. enterica serovar TyphimuriumPutative inner membrane protein	1.20.5.980	99	8	46	1.70	3.66
3b8eB00	75.25	Sodium/potassium-transporting ATPase subunit beta-1Sus scrofa	1.20.5.170	46	4	58	2.04	3.48
1hf9A00	74.74	Protein homodimerization activityNegative regulation of hydrolase activityATPase inhibitor activityBos taurusATPase binding	1.20.5.500	41	7	50	1.71	3.42
1mqsB00	73.86	Vesicle fusionSyntaxin 5SNAP receptor activityER to Golgi vesicle-mediated transportRetrograde vesicle-mediated transport, Golgi to ER	1.20.5.460	26	3	56	2.43	4.30
3c8vA04	73.66	Desulfovibrio desulfuricans subsp. desulfuricans str. G20Putative uncharacterized protein	1.20.5.510	19	10	41	0.90	2.18
1xvhA02	73.56	Extracellular matrix-binding protein ebhStaphylococcus aureus subsp. aureus MW2	1.20.5.420	55	2	38	1.18	3.09
1mg1A03	73.26	Bacterial chemotaxisABC transportersMaltose/maltodextrin transport system substrate-binding proteinEscherichia coli O157:H7Maltose-binding periplasmic protein	1.10.287.210	84	8	44	2.13	4.84
2oarA02	72.31	Large conductance mechanosensitive channel, MscL familyLarge-conductance mechanosensitive channelMycobacterium tuberculosis H37Ra	1.20.5.220	17	17	36	0.74	2.00
2otkE00	71.30		1.20.5.420	43	0	43	1.90	4.37
1ik9B02	69.40	DNA ligation involved in DNA repairResponse to X-rayDNA-dependent protein kinase-DNA ligase 4 complexProtein C-terminus bindingDouble-strand break repair via nonhomologous end joining	1.20.5.370	83	2	30	0.84	2.79
1d66B02	67.27	Regulatory protein GAL4NucleusSequence-specific DNA binding transcription factor activityTranscription activator activityPositive regulation of transcription by galactose	1.20.5.640	15	6	30	0.48	1.58
1jocA01	67.14	Zinc ion bindingVesicle fusionMembrane fractionSynaptic vesicle to endosome fusionProtein homodimerization activity	1.20.5.390	60	0	33	1.52	4.56
1a2xB00	64.85	Troponin I, fast skeletal muscleTroponin T bindingOryctolagus cuniculus	1.20.5.420	31	9	34	1.60	4.60
1mkmA02	64.42	Thermotoga maritimaTranscriptional regulator, IclR family	1.20.5.640	14	28	30	0.77	2.53
2qiwA02	64.27	Corynebacterium glutamicumPEP phosphonomutase and related enzymes	1.20.5.510	18	16	34	1.73	4.97
1mslA02	63.94		1.20.5.220	18	5	34	1.61	4.63
1pgjA03	62.17	6-phosphogluconate dehydrogenase, decarboxylatingTrypanosoma brucei brucei	1.20.5.320	34	0	30	1.48	4.86

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Domain ATOM Sequence

>pdb|2basA02
LKQRLKTEFHQFITHEKKKLETVYEHSEQFYKRVHQAVTSLRKNNL

BLAST against CATH

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Domain COMBS Sequence

>pdb|2basA02
LKQRLKTEFHQFITHEKKKLETVYEHSEQFYKRVHQAVTSLRKNNL

BLAST against CATH

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Domain History Events (12)

Domain assigned by auto on 25 Apr 2008 14:24

Assigning to "1.20.5.170" based on similarity with "2basB02"