CATH Domain: 2ak5B00 XML data for domain: 2ak5B00

Molscript image for 2ak5B00
2ak5B00
PDB coordinates for domain 2ak5B00

PDB 2ak5, Chain B, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.17
2.30.30.40.17.1
2.30.30.40.17.1.1
2.30.30.40.17.1.1.1
2.30.30.40.17.1.1.1.1

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Segment boundaries for domain 2ak5B00

Chopping figure for domain 2ak5B00
DomainStart PDB ResidueStop PDB Residue
2ak5B00 3 66

Structural Neighbourhood (46 entries)

There are 46 matching structural neighberhood comparisons for CATH ID 2.30.30.40.17.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 46 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vwfA00 92.34 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 41 87 0.96 1.10
2j6fA00 92.03 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 35 87 1.13 1.29
2jteA00 91.97 Mus musculusCD2-associated protein 2.30.30.40 64 40 96 3.34 3.45
1ov3A02 91.68 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 27 84 0.80 0.95
1ckaA00 91.52 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 33 85 1.20 1.40
2v1rA00 91.13 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 28 89 2.23 2.49
1ad5A01 90.94 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 26 92 2.26 2.45
1x6bA01 90.82 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 29 92 1.82 1.97
1ng2A02 90.60 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 23 88 3.71 4.20
2rqtA00 90.42 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 34 90 1.49 1.64
1yn8A00 90.33 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 23 89 1.35 1.52
1ycsB02 90.30 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 23 95 3.20 3.36
2csqA01 90.00 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 28 86 1.45 1.68
1wx6A01 89.99 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 29 92 2.27 2.46
3ehrB01 89.93 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 35 90 1.76 1.94
1jegA00 89.77 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 36 90 1.72 1.90
2ablA01 89.52 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 26 95 3.29 3.45
2vknA00 89.28 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 29 92 2.40 2.60
1griA01 88.93 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 39 75 0.67 0.89
1uhfA00 88.65 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 29 91 2.79 3.06
1gcqC00 88.65 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 25 86 2.77 3.19
1j3tA00 88.64 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 34 85 2.37 2.78
1spkA00 87.83 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 35 88 2.04 2.29
2js2A00 87.57 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 31 96 4.71 4.86
1awwA00 87.47 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 29 95 3.68 3.85
2epdA00 86.65 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 29 84 3.16 3.75
2ke9A00 86.30 Caskin-2Homo sapiens 2.30.30.40 67 29 89 3.02 3.37
1ng2A01 86.13 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 29 68 1.47 2.14
1bb9A00 86.10 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 26 74 3.59 4.81
3i5rA00 85.86 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 26 76 2.67 3.49
1tucA00 83.86 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 61 19 73 3.62 4.93
1jxmA01 82.87 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 25 70 2.64 3.77
1uffA00 81.96 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 40 67 2.19 3.23
2heqA01 81.71 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 11 79 2.78 3.49
1ug1A00 81.55 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 17 69 3.14 4.51
1u3oA01 81.17 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 11 87 4.03 4.61
1igqB00 81.08 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 7 76 2.83 3.70
1dj7B00 80.97 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 14 78 3.47 4.44
2o2oA00 80.29 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 37 85 3.47 4.07
2g3rA01 80.28 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 15 81 3.43 4.22
1jb0E00 79.95 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 14 75 3.30 4.38
1biaA03 77.42 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 8 73 3.25 4.43
1kq1H00 76.62 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 3 77 3.81 4.93
2k57A00 76.36 Pseudomonas syringae pv. phaseolicola 1448ALipoprotein, putative 2.30.30.100 55 18 75 3.72 4.96
1irxA02 75.96 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 11 65 2.84 4.33
1awjA00 75.69 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 23 79 3.80 4.80
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Displaying entries 1 to 46 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|2ak5B00
GSANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPS
BLAST against CATH

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Domain COMBS Sequence 

>pdb|2ak5B00
GSANSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPS
BLAST against CATH

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Domain History Events (7)

Domain assigned by auto on 14 Aug 2007 23:02

Assigning to "2.30.30.40" based on similarity with "2ak5A00"

Flow stage update by auto on 14 Aug 2007 22:48

No in_process hits for Domain "2ak5B00" ready to be processed

Flow stage update by auto on 21 Jul 2007 03:22

Domain "2ak5B00" hits Domain "2ak5A00" (100% over 100%) which is currently in process

Flow stage update by auto on 21 Jul 2007 03:22

NW result present for Domain "2ak5B00"

Flow stage update by auto on 14 Jul 2007 06:01

All required files are present for Domain "2ak5B00"

Flow stage update by auto on 13 Jul 2007 18:42

Beginning processing for Domain "2ak5B00"

Insertion by auto on 13 Jul 2007 03:59

Final ChopClose added based on similarity with "1ujyA"