CATH Domain: 2a4xA00

2a4xA00

PDB 2a4x, Chain A, Domain 0

CATH Code	Level Description	Links
3	Alpha Beta
3.10	Roll
3.10.180	2,3-Dihydroxybiphenyl 1,2-Dioxygenase; domain 1
3.10.180.10	2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1	Gene3D
3.10.180.10.4
3.10.180.10.4.1
3.10.180.10.4.1.1
3.10.180.10.4.1.1.1
3.10.180.10.4.1.1.1.1

Structure
Sequence
History

[top]
Segment boundaries for domain 2a4xA00

Domain	Start PDB Residue	Stop PDB Residue
2a4xA00	2	132

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (14 entries)

There are 14 matching structural neighberhood comparisons for CATH ID 3.10.180.10.4.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
2rbbA00	87.84	Burkholderia phytofirmans PsJNGlyoxalase/bleomycin resistance protein/dioxygenase	3.10.180.10	126	18	95	2.64	2.77
1f9zA00	85.35	Pyruvate metabolismLactoylglutathione lyase activityNickel ion bindingMethylglyoxal catabolic process to D-lactateLactoylglutathione lyase [EC:4.4.1.5]	3.10.180.10	128	15	90	4.06	4.47
3ct8A00	84.83	BH2160 proteinBacillus halodurans	3.10.180.10	131	13	90	3.58	3.94
2rk0A01	83.27	Glyoxalase/bleomycin resistance protein/dioxygenaseFrankia sp. EAN1pec	3.10.180.10	119	13	87	3.90	4.48
3huhA01	82.67	Virulence protein STM3117Salmonella enterica subsp. enterica serovar Typhimurium	3.10.180.10	119	15	87	3.73	4.29
3ghjA00	82.64	Uncultured bacteriumPutative integron gene cassette protein	3.10.180.10	114	18	86	4.01	4.65
2p7oA00	82.39	Listeria monocytogenes serotype 4b str. F2365Glyoxalase family protein	3.10.180.10	127	16	90	4.29	4.76
2i7rA00	82.11	Conserved domain proteinStreptococcus pneumoniae	3.10.180.10	112	16	85	2.96	3.46
1ss4A00	82.01	Glyoxalase family proteinBacillus cereus ATCC 14579	3.10.180.10	143	14	83	3.59	4.28
2qntA01	81.75	Agrobacterium tumefaciens str. C58Putative uncharacterized protein	3.10.180.10	109	20	83	3.09	3.71
2qqzA01	81.48	Bacillus anthracisGlyoxalase family protein	3.10.180.10	113	16	81	3.96	4.85
2p25A01	81.24	Glyoxylase I family proteinGlyoxylase family proteinEnterococcus faecalis	3.10.180.10	118	18	83	3.72	4.47
1ecsA00	81.22	Klebsiella pneumoniaeBleomycin resistance protein	3.10.180.10	120	16	86	4.01	4.65
1u6lA01	76.97	Pseudomonas aeruginosaPhnB proteinPutative uncharacterized protein	3.10.180.10	120	10	80	3.44	4.29

[top]
Domain ATOM Sequence

>pdb|2a4xA00
SARISLFAVVVEDMAKSLEFYRKLGVEIPAEADSAPHTEAVLDGGIRLAWDTVETVRSYDPEWQAPTGGHRFAIAFEFPD
TASVDKKYAELVDAGYEGHLKPWNAVWGQRYAIVKDPDGNVVDLFAPLPLE

BLAST against CATH

[top]
Domain COMBS Sequence

>pdb|2a4xA00
MSARISLFAVVVEDMAKSLEFYRKLGVEIPAEADSAPHTEAVLDGGIRLAWDTVETVRSYDPEWQAPTGGHRFAIAFEFP
DTASVDKKYAELVDAGYEGHLKPWNAVWGQRYAIVKDPDGNVVDLFAPLPLEHHHHHH

BLAST against CATH

[top]
Domain History Events (13)

Domain assigned by auto on 02 Nov 2006 03:34

Assigning to "3.10.180.10" based on similarity with "2a4wA00"

Flow stage update by auto on 02 Nov 2006 03:17

No in_process hits for Domain "2a4xA00" ready to be processed

Update comment by auto on 01 Nov 2006 21:56

Domain "2a4xA00" hits Domain "2a4wA00" (100% over 100%) which is currently in process