CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt Q9Y3C6
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Q9Y3C6
PPIL1_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase-like 1

PDB Structure

PDB 1XWN
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
Solution structure of human peptidyl prolyl isomerase like protein 1 and insights into its interaction with SKIP
Xu, C., Zhang, J., Huang, X., Sun, J., Xu, Y., Tang, Y., Wu, J., Shi, Y., Huang, Q., Zhang, Q.
J.Biol.Chem.