CATH Domain: 1wxuA01 XML data for domain: 1wxuA01

Molscript image for 1wxuA01
1wxuA01
PDB coordinates for domain 1wxuA01

PDB 1wxu, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.4
2.30.30.40.4.2
2.30.30.40.4.2.1
2.30.30.40.4.2.1.1
2.30.30.40.4.2.1.1.1

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Segment boundaries for domain 1wxuA01

Chopping figure for domain 1wxuA01
DomainStart PDB ResidueStop PDB Residue
1wxuA01 16 81

Structural Neighbourhood (69 entries)

There are 69 matching structural neighberhood comparisons for CATH ID 2.30.30.40.4.2.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 69 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2v1rA00 91.40 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 29 88 1.09 1.24
2jteA00 91.11 Mus musculusCD2-associated protein 2.30.30.40 64 26 88 1.02 1.16
2ak5B00 91.10 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 28 88 1.41 1.60
2vwfA00 90.69 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 30 82 1.03 1.25
2v1qA00 90.54 Actin cortical patch assemblyMating projection tipIdentical protein bindingNucleusActin filament organization 2.30.30.40 60 31 85 1.18 1.38
1w70A00 90.44 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 31 85 1.19 1.40
3h0hA00 90.33 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 30 85 1.36 1.59
2j6fA00 90.27 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 33 83 1.04 1.24
1zlmA00 90.21 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 58 31 83 1.20 1.43
1ckaA00 90.13 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 25 80 1.23 1.52
3i9qA00 89.97 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 36 83 1.24 1.48
1ov3A02 89.94 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 27 79 0.96 1.21
1ng2A02 89.90 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 22 82 1.15 1.40
1wx6A01 89.87 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 28 94 1.84 1.96
1sshA00 89.57 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion 2.30.30.40 60 35 86 3.00 3.46
1yn8A00 89.54 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 27 83 1.10 1.31
2ablA01 89.41 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 28 88 1.82 2.06
2vknA00 89.27 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 28 89 2.09 2.33
1ad5A01 89.26 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 31 89 3.72 4.15
1ycsB02 89.14 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 28 88 1.78 2.02
1y0mA00 89.12 Rattus norvegicusCalcium signaling pathwayPhosphatidylinositol signaling systemPathways in cancerPhospholipase C, gamma [EC:3.1.4.11] 2.30.30.40 60 31 86 1.49 1.72
2rqtA00 88.95 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 27 85 1.36 1.59
1jo8A00 88.95 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 32 82 1.34 1.63
1x6bA01 88.92 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 21 91 4.16 4.56
2csqA01 88.86 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 23 83 1.22 1.46
3eg3A00 88.82 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 62 27 86 1.91 2.20
3ehrB01 88.58 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 29 83 1.54 1.84
3i35A00 88.35 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 30 80 1.53 1.89
1zuyA00 88.25 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 31 80 1.36 1.68
1j3tA00 87.83 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 35 86 4.09 4.73
1jegA00 87.81 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 25 86 1.65 1.90
1spkA00 87.77 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 25 88 2.24 2.52
1gcqC00 87.20 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 17 85 2.42 2.83
2js2A00 86.90 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 23 85 2.27 2.66
1griA01 86.90 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 41 70 0.81 1.15
1awwA00 86.55 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 25 88 1.93 2.19
2ke9A00 85.24 Caskin-2Homo sapiens 2.30.30.40 67 29 88 3.54 4.01
1bb9A00 85.08 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 20 73 2.34 3.18
3i5rA00 84.98 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 26 80 2.67 3.33
1ng2A01 83.87 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 27 64 1.50 2.32
2hbwA01 83.13 Anabaena variabilis ATCC 29413NLP/P60 2.30.30.40 72 13 86 3.96 4.60
2aklA02 82.44 Phosphonate and phosphinate metabolismPseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Putative uncharacterized protein 2.30.30.40 73 8 80 2.97 3.67
1dj7B00 82.32 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 8 82 3.66 4.45
1jb0E00 81.87 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 8 76 2.58 3.36
2heqA01 81.78 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 11 76 2.74 3.58
1u3oA01 81.75 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 25 82 2.62 3.18
1igqB00 81.29 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 7 73 2.71 3.69
1ri9A00 80.36 FYN-binding proteinProtein phosphorylationNucleusHomo sapiensImmune response 2.30.30.40 77 16 72 2.67 3.67
1sf9A02 80.22 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 7 64 2.09 3.23
1mhnA00 80.19 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 8 76 3.68 4.81
2g3rA01 80.11 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 9 73 2.88 3.92
2rh2A00 79.94 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 7 69 2.44 3.53
1khcA01 79.76 Protein complex localizationRegulation of gene expression by genetic imprintingDNA (cytosine-5)-methyltransferase 3BChromosome, centromeric regionProtein binding 2.30.30.160 65 10 73 3.33 4.53
1m9sA05 79.30 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 78 10 75 3.01 3.98
1m9sA04 79.06 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 86 14 73 3.58 4.89
1biaA03 78.52 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 12 67 2.62 3.87
1ib8A02 77.27 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 4 73 3.00 4.08
1vytA01 76.93 Cardiac muscle contractionRattus norvegicusDilated cardiomyopathyVoltage-gated calcium channel complexCalcium channel, voltage-dependent, beta 3 subunit 2.30.30.40 108 11 53 1.82 3.39
1awjA00 76.74 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 23 75 2.80 3.72
1kq1H00 76.69 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 9 69 2.73 3.95
1bi1A03 76.40 DtxR family transcriptional regulator, Mn-dependent transcriptional regulatorDiphtheria toxin repressorCorynebacterium diphtheriae 2.30.30.90 74 8 70 3.35 4.77
2vv5A02 76.33 Escherichia coli O157:H7Small conductance mechanosensitive ion channel, MscS familySmall-conductance mechanosensitive channel 2.30.30.60 50 12 60 2.52 4.18
1n9rB00 75.77 Protein bindingNuclear mRNA splicing, via spliceosomeSmall nuclear ribonucleoprotein FSmall nuclear ribonucleoprotein FU5 snRNP 2.30.30.100 69 5 71 3.14 4.42
1mgqF00 75.76 Methanothermobacter thermautotrophicus str. Delta HSmall nuclear ribonucleoproteinPutative snRNP Sm-like protein 2.30.30.100 70 7 65 3.23 4.92
3fb9B00 75.31 Streptococcus pneumoniaePutative uncharacterized protein 2.30.30.100 84 4 53 2.59 4.83
1m5q101 75.18 Pyrobaculum aerophilumSmall nuclear ribonucleoprotein homolog (Sm-like) 2.30.30.100 67 5 70 3.36 4.76
1irxA02 74.43 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 11 61 3.04 4.92
3by7E00 74.04 2.30.30.100 74 2 67 2.92 4.32
1b3qB03 68.56 Thermotoga maritimaBacterial chemotaxisTwo-component systemTwo-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]Protein binding 2.30.30.40 68 4 42 2.13 4.99
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Displaying entries 1 to 69 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1wxuA01
DHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRR
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1wxuA01
DHVVARAEYDFVAVSDEEISFRAGDMLNLALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRR
BLAST against CATH

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Domain History Events (6)

Domain assigned by auto on 22 Dec 2006 11:43

Assigning to "2.30.30.40" based on similarity with "2a37A00"

Flow stage update by auto on 22 Dec 2006 11:40

No in_process hits for Domain "1wxuA01" ready to be processed

Flow stage update by auto on 22 Dec 2006 11:40

NW result present for Domain "1wxuA01"

Flow stage update by auto on 21 Dec 2006 15:34

All required files are present for Domain "1wxuA01"

Flow stage update by auto on 21 Dec 2006 15:34

Beginning processing for Domain "1wxuA01"

Insertion by cuff on 21 Dec 2006 11:59

nice selection of choppings