CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt Q02834
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

Q02834
NANH_MICVI
Micromonospora viridifaciens
Sialidase

PDB Structure

PDB 1W8O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Contribution of the Active Site Aspartic Acid to Catalysis in the Bacterial Neuraminidase from Micromonospora Viridifaciens
Watson, J.N., Newstead, S., Dookhun, V., Taylor, G., Bennet, A.J.
FEBS Lett.