CATH Domain: 1w70A00 XML data for domain: 1w70A00

Molscript image for 1w70A00
1w70A00
PDB coordinates for domain 1w70A00

PDB 1w70, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.12
2.30.30.40.12.1
2.30.30.40.12.1.1
2.30.30.40.12.1.1.1
2.30.30.40.12.1.1.1.1

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Segment boundaries for domain 1w70A00

Chopping figure for domain 1w70A00
DomainStart PDB ResidueStop PDB Residue
1w70A00 169 228

Structural Neighbourhood (71 entries)

There are 71 matching structural neighberhood comparisons for CATH ID 2.30.30.40.12.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 71 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vwfA00 94.22 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 33 93 0.97 1.04
2jteA00 93.00 Mus musculusCD2-associated protein 2.30.30.40 64 30 93 1.36 1.45
1ckaA00 92.73 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 30 91 1.12 1.22
2j6fA00 92.71 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 29 93 1.16 1.24
3i35A00 92.31 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 32 91 1.24 1.35
2ak5B00 92.29 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 35 93 2.24 2.39
3i9qA00 92.11 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 33 95 1.20 1.26
2rqtA00 92.04 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 30 93 1.27 1.36
1yn8A00 91.26 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 30 95 1.39 1.46
3h0hA00 90.98 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 25 95 2.32 2.44
1jegA00 90.96 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 23 96 1.43 1.48
1zuyA00 90.32 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 31 91 1.53 1.67
1ov3A02 90.32 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 16 90 1.34 1.49
3ehrB01 90.19 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 25 93 1.82 1.95
2v1rA00 90.19 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 30 88 1.94 2.20
1wx6A01 90.15 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 21 89 1.39 1.55
2ablA01 89.98 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 18 90 3.13 3.44
1x6bA01 89.94 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 25 89 1.28 1.44
1ad5A01 89.93 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 20 90 1.55 1.71
2csqA01 89.90 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 23 86 1.56 1.81
2js2A00 89.10 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 21 93 3.70 3.95
1griA01 88.90 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 31 80 1.07 1.34
2vknA00 88.88 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 20 89 1.90 2.13
1gcqC00 88.67 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 21 86 2.69 3.09
1j3tA00 88.55 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 35 79 2.39 3.00
1ycsB02 88.37 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 20 92 2.36 2.56
1uhfA00 87.93 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 23 85 2.71 3.17
1ng2A02 87.70 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 15 85 1.63 1.91
1spkA00 87.61 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 33 83 2.46 2.95
1awwA00 87.26 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 23 89 1.88 2.10
2epdA00 87.21 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 31 78 1.55 1.96
2ke9A00 85.53 Caskin-2Homo sapiens 2.30.30.40 67 28 86 2.55 2.95
1bb9A00 85.26 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 28 72 1.95 2.70
1tucA00 85.08 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 61 26 73 3.30 4.47
1ng2A01 84.63 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 18 73 1.96 2.67
3i5rA00 84.50 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 23 74 2.35 3.17
1u3oA01 84.12 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 21 90 2.40 2.66
1sf9A02 83.63 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 7 76 2.64 3.44
2heqA01 82.66 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 9 85 2.90 3.41
1jxmA01 82.47 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 21 67 2.67 3.96
2rh2A00 82.06 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 8 80 2.95 3.69
1igqB00 81.97 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 10 75 2.67 3.56
1i1jB00 81.97 Melanoma-derived growth regulatory proteinHomo sapiensExtracellular spaceCell proliferation 2.30.30.40 103 25 58 1.66 2.85
1udlA00 81.78 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 98 30 61 1.93 3.15
1uffA00 81.74 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 26 64 2.42 3.75
2g3rA01 81.67 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 5 83 2.99 3.59
1mhnA00 81.51 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 8 85 3.54 4.16
1dj7B00 80.79 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 8 80 3.99 4.94
2aklA02 80.73 Phosphonate and phosphinate metabolismPseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Putative uncharacterized protein 2.30.30.40 73 10 80 3.71 4.59
1ug1A00 80.15 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 15 65 2.47 3.79
2o2oA00 80.10 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 31 80 2.88 3.60
1jb0E00 80.08 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 13 75 3.01 3.99
1khcA01 79.67 Protein complex localizationRegulation of gene expression by genetic imprintingDNA (cytosine-5)-methyltransferase 3BChromosome, centromeric regionProtein binding 2.30.30.160 65 5 75 3.52 4.67
1ri9A00 79.32 FYN-binding proteinProtein phosphorylationNucleusHomo sapiensImmune response 2.30.30.40 77 10 74 2.56 3.46
1biaA03 79.26 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 6 78 3.48 4.44
1m9sA05 78.95 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 78 5 74 2.91 3.91
1m9sA04 78.91 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 86 11 69 3.18 4.56
2k57A00 78.68 Pseudomonas syringae pv. phaseolicola 1448ALipoprotein, putative 2.30.30.100 55 9 76 3.24 4.23
2vv5A02 78.54 Escherichia coli O157:H7Small conductance mechanosensitive ion channel, MscS familySmall-conductance mechanosensitive channel 2.30.30.60 50 12 71 2.69 3.75
1vytA01 78.16 Cardiac muscle contractionRattus norvegicusDilated cardiomyopathyVoltage-gated calcium channel complexCalcium channel, voltage-dependent, beta 3 subunit 2.30.30.40 108 16 55 1.86 3.35
1ib8A02 77.84 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 16 76 2.55 3.35
1kq1H00 77.64 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 6 68 2.54 3.73
1irxA02 76.85 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 2 66 2.62 3.93
1u1sA00 76.69 RNA degradationPseudomonas aeruginosaHost factor-I proteinProtein hfq 2.30.30.100 66 1 68 3.22 4.72
2ra2B00 76.67 Salmonella enterica subsp. enterica serovar TyphimuriumPutative lipoprotein 2.30.30.100 55 7 76 3.56 4.64
2hjqA01 75.65 Uncharacterized protein yqbFBacillus subtilis 3.40.5.20 46 10 73 3.57 4.87
1pm3A00 75.29 Methanothermobacter thermautotrophicus str. Delta HPutative uncharacterized protein 2.30.30.240 69 13 66 3.23 4.84
1d3bC00 74.64 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D3Small nuclear ribonucleoprotein D3Spliceosomal complex 2.30.30.100 71 10 64 2.36 3.64
2qgqA02 73.90 Thermotoga maritimaRibosomal protein S12 methylthiotransferase rimO 2.40.50.140 59 5 55 2.34 4.25
1b34A00 72.11 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D1RNA bindingProtein binding 2.30.30.100 80 3 60 2.72 4.53
1d3bB00 71.75 Small nuclear ribonucleoprotein-associated proteins B and B'Spliceosomal complexU7 snRNPHomo sapiensProtein binding 2.30.30.100 81 6 56 2.54 4.47
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Displaying entries 1 to 71 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1w70A00
LIKHMRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILK
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1w70A00
LIKHMRAEALFDFTGNSKLELNFKAGDVIFLLSRINKDWLEGTVRGATGIFPLSFVKILK
BLAST against CATH

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Domain History Events (10)

Domain assigned by auto on 05 Nov 2006 09:24

Assigning to "2.30.30.40" based on similarity with "1w6xA00"

Flow stage update by auto on 05 Nov 2006 09:23

No in_process hits for Domain "1w70A00" ready to be processed

Update comment by auto on 05 Nov 2006 05:23

Domain "1w70A00" hits Domain "1w70B00" (100% over 100%) which is currently in process

Update comment by auto on 05 Nov 2006 01:35

Domain "1w70A00" hits Domain "1w6xB00" (100% over 100%) which is currently in process

Update comment by auto on 04 Nov 2006 21:25

Domain "1w70A00" hits Domain "1w6xA00" (100% over 100%) which is currently in process

Flow stage update by auto on 04 Nov 2006 21:24

Domain "1w70A00" hits Domain "1w6xA00" (100% over 100%) which is currently in process

Flow stage update by auto on 04 Nov 2006 21:24

NW result present for Domain "1w70A00"

Flow stage update by auto on 02 Nov 2006 14:22

All required files are present for Domain "1w70A00"

Flow stage update by auto on 01 Nov 2006 21:55

Beginning processing for Domain "1w70A00"

Insertion by auto on 01 Nov 2006 21:19

Final ChopClose added based on similarity with "1w6xA"