CATH Domain: 1w1hD00 XML data for domain: 1w1hD00

Molscript image for 1w1hD00
1w1hD00
PDB coordinates for domain 1w1hD00

PDB 1w1h, Chain D, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.14
2.30.29.30.14.1
2.30.29.30.14.1.1
2.30.29.30.14.1.1.1
2.30.29.30.14.1.1.1.1

Segment boundaries for domain 1w1hD00

Chopping figure for domain 1w1hD00
DomainStart PDB ResidueStop PDB Residue
1w1hD00 412 548

Structural Neighbourhood (27 entries)

There are 27 matching structural neighberhood comparisons for CATH ID 2.30.29.30.14.1.1.1.1 (SIMAX score < 5)

Displaying entries 1 to 27 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2dn6A00 82.76 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 15 71 2.28 3.19
1faoA00 81.84 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 17 67 2.30 3.42
1kz7C02 81.72 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 11 71 2.49 3.48
2rgnB02 81.42 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 12 67 1.95 2.90
1v89A00 80.58 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 14 70 2.82 3.98
1v88A00 80.48 Oxysterol-binding protein-related protein 8Homo sapiens 2.30.29.30 130 6 70 2.85 4.03
3cxbB00 80.45 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 10 64 2.47 3.85
1q67A01 80.28 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 7 70 2.59 3.66
1qqgA02 80.27 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 11 65 2.38 3.62
1omwA05 79.83 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 12 66 2.50 3.76
2he7A03 79.82 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 10 62 1.87 2.98
1ki1B02 79.77 Synaptic vesicle endocytosisHomo sapiensProtein bindingIntersectin-1 2.30.29.30 142 10 75 3.24 4.30
1qqgA01 79.45 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 14 62 2.24 3.57
1aqcB00 79.32 Nervous system developmentSynaptic transmissionCell adhesionAmyloid beta (A4) precursor protein-binding, family A, member 1 (X11)Axon cargo transport 2.30.29.30 114 4 60 2.47 4.08
2dhjA00 79.29 Rho GTPase-activating protein 21Homo sapiens 2.30.29.30 125 10 71 2.84 3.97
1ntvA00 79.27 Radial glia guided migration of Purkinje cellDisabled homolog 1Cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migrationNegative regulation of cell adhesionMus musculus 2.30.29.30 152 6 69 3.42 4.95
1zsqA01 78.65 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 11 63 2.38 3.75
1btnA00 78.24 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 6 60 2.50 4.13
1foeC02 78.23 Positive regulation of axonogenesisPlasma membraneEphrin receptor signaling pathwayEphrin receptor bindingMus musculus 2.30.29.30 159 8 62 2.70 4.34
1dbhA02 78.21 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 7 70 3.24 4.62
1plsA00 78.13 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 12 68 2.59 3.77
1mixA02 77.91 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 15 63 2.47 3.89
2coaA01 77.84 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 16 66 3.00 4.52
1ef1A03 77.41 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 9 63 2.50 3.94
1p5tA00 77.31 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity 2.30.29.30 105 8 62 2.75 4.38
1ddmA00 77.08 Notch signaling pathwaySensory organ precursor cell fate determinationSensory organ precursor cell divisionProtein localizationDrosophila melanogaster 2.30.29.30 135 8 73 3.25 4.41
1xr0B01 76.87 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 10 60 2.21 3.65
Displaying entries 1 to 27 (page 1 of 1)


Domain ATOM Sequence

>pdb|1w1hD00
IEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVN
KVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQ    

Domain COMBS Sequence

>pdb|1w1hD00
GPLGSNIEQYIHDLDSNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLY
YVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQRYQSHPDAAVQ    

Domain History Events (5)

Domain assigned by auto on 28 Apr 2006 19:30

Assigning to "2.30.29.30" based on similarity with "1w1hC00" (NWSI: 100, NWO: 100, SPS: 96.29, SPO: 99, RMSD: 0.85)

Flow stage update by auto on 28 Apr 2006 17:50

NW result present for Domain "1w1hD00"

Flow stage update by auto on 28 Apr 2006 17:45

All required files are present for Domain "1w1hD00"

Flow stage update by auto on 27 Apr 2006 17:31

Beginning processing for Domain "1w1hD00"

Insertion by auto on 09 Mar 2006 10:10

Final ChopClose added based on similarity with "1w1hB" [LEE: 0, LME: 0, MR: 8, LG: 8, SS: 95.59, SI: 100, SO: 100]