CATH Domain: 1uu3A02 XML data for domain: 1uu3A02

Molscript image for 1uu3A02
1uu3A02
PDB coordinates for domain 1uu3A02

PDB 1uu3, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.200 Phosphorylase Kinase; domain 1
3.30.200.20 Phosphorylase Kinase; domain 1 Gene3D
3.30.200.20.11
3.30.200.20.11.1
3.30.200.20.11.1.1
3.30.200.20.11.1.1.1
3.30.200.20.11.1.1.1.1

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Segment boundaries for domain 1uu3A02

Chopping figure for domain 1uu3A02
DomainStart PDB ResidueStop PDB Residue
1uu3A01 166 357
1uu3A02 73 165

Structural Neighbourhood (63 entries)

There are 63 matching structural neighberhood comparisons for CATH ID 3.30.200.20.11.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 63 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vgpB01 92.25 Serine/threonine-protein kinase 12-AHistone H3-S10 phosphorylationChromosome, centromeric regionProtein bindingChromatin 3.30.200.20 89 34 95 1.78 1.86
2acxA02 92.18 G protein-coupled receptor kinase 6Homo sapiensRegulation of G-protein coupled receptor protein signaling pathway 3.30.200.20 91 25 97 1.10 1.12
2rkuA01 90.87 Polo-like kinase 1 [EC:2.7.11.21]Polo kinase kinase activityProgesterone-mediated oocyte maturationCell proliferationOocyte meiosis 3.30.200.20 89 21 95 1.92 2.01
3c0iA01 90.64 Actin cytoskeletonGuanylate kinase activityPeripheral plasma membrane protein CASKCell adhesionHomo sapiens 3.30.200.20 88 22 92 1.70 1.84
1o6lA02 89.95 Jak-STAT signaling pathwayRAC-beta serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.30.200.20 117 39 76 0.74 0.96
3d5vA01 89.56 Danio rerioPolo-like kinase 3.30.200.20 92 20 92 3.01 3.25
2h6dA01 89.48 Insulin signaling pathwayHypertrophic cardiomyopathy (HCM)Adipocytokine signaling pathwayRegulation of autophagyMTOR signaling pathway 3.30.200.20 86 24 92 2.94 3.18
3f3zA01 89.06 Cryptosporidium parvum Iowa IICalcium-dependent protein kinase [EC:2.7.11.1]Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands 3.30.200.20 81 27 87 1.66 1.91
2wtkC01 88.87 NucleusSerine/threonine-protein kinase 11Cell cycle arrestProtein bindingSerine/threonine-protein kinase 11 [EC:2.7.11.9] 3.30.200.20 89 24 91 3.88 4.25
2dylA01 88.68 Mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]MAP kinase kinase activityNeurotrophin signaling pathwayStress-activated MAPK cascadeT cell receptor signaling pathway 3.30.200.20 91 14 88 2.18 2.47
1x8bA01 88.30 Homo sapiensWee1-like protein kinaseProtein binding 3.30.200.20 84 17 89 3.72 4.17
1rdqE02 88.23 Calcium signaling pathwayPrion diseasesProtein kinase A [EC:2.7.11.11]Olfactory transductionMesoderm formation 3.30.200.20 124 31 75 1.79 2.39
2weiA01 88.15 Cryptosporidium parvum Iowa IICalmodulin-domain protein kinase 1, putative 3.30.200.20 90 25 96 3.91 4.04
1tkiA01 88.00 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 3.30.200.20 84 20 90 2.75 3.04
2jamA01 87.99 Calcium/calmodulin-dependent protein kinase type 1GHomo sapiensCalcium/calmodulin-dependent protein kinase I [EC:2.7.11.17] 3.30.200.20 75 25 80 1.58 1.96
1q5kA01 87.90 Hedgehog signaling pathwayNeurotrophin signaling pathwayAlzheimer's diseaseT cell receptor signaling pathwayER overload response 3.30.200.20 95 24 85 2.47 2.90
2j51A01 87.72 CytoplasmOocyte meiosisSTE20-like serine/threonine-protein kinasePlasma membraneHomo sapiens 3.30.200.20 90 22 92 3.13 3.38
2clqA01 87.45 Induction of apoptosis by extracellular signalsProtein homodimerization activityMitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]Neurotrophin signaling pathwayATP binding 3.30.200.20 85 17 83 1.67 1.99
2zv2A01 87.37 Calcium ion bindingRegulation of protein kinase activityPositive regulation of transcriptionMAPKKK cascadeCytoplasm 3.30.200.20 77 27 80 2.19 2.72
1xwsA01 87.35 Transcription factor bindingPositive regulation of cyclin-dependent protein kinase activity involved in G1/SManganese ion bindingNegative regulation of apoptosisProtein binding 3.30.200.20 92 18 90 2.38 2.63
1zy4A01 87.33 Eukaryotic translation initiation factor 2alpha kinase activityProtein bindingSerine/threonine-protein kinase GCN2DNA damage checkpointRegulation of translational initiation 3.30.200.20 94 27 92 2.81 3.04
3eqrB01 87.28 Activated CDC42 kinase 1GTPase inhibitor activitySmall GTPase mediated signal transductionHomo sapiensPositive regulation of peptidyl-tyrosine phosphorylation 3.30.200.20 91 20 94 2.78 2.94
3k3iA01 87.19 Cellular component movementMAP kinase kinase activityProtein bindingChemotaxisMitogen-activated protein kinase 14 3.30.200.20 92 16 91 3.22 3.52
1u5qA01 87.18 Rattus norvegicusThousand and one amino acid protein kinase [EC:2.7.11.1]Serine/threonine-protein kinase TAO2MAPK signaling pathway 3.30.200.20 96 19 92 2.42 2.61
2evaA01 87.07 Positive regulation of T cell cytokine productionActivation of NF-kappaB-inducing kinase activityPositive regulation of interleukin-2 productionMitogen-activated protein kinase kinase kinase 7Protein binding 3.30.200.20 82 24 88 2.53 2.87
3blhA01 87.04 Transcription elongation from RNA polymerase II promoterCyclin-dependent protein kinase activityRNA polymerase II carboxy-terminal domain kinase activityProtein bindingCell proliferation 3.30.200.20 86 22 90 2.53 2.80
3comB01 86.96 Transcription factor bindingPathways in cancerNon-small cell lung cancerCytoplasmSerine/threonine-protein kinase 4 3.30.200.20 85 24 86 1.87 2.17
2j0iA01 86.90 Cellular component movementT cell receptor signaling pathwaySignal transductionProtein bindingRenal cell carcinoma 3.30.200.20 98 16 87 2.54 2.89
2jedB01 86.88 Protein kinase C theta typeProtein bindingT cell receptor signaling pathwayNovel protein kinase C [EC:2.7.11.13]Adipocytokine signaling pathway 3.30.200.20 125 34 71 2.70 3.79
3e64A01 86.80 Jak-STAT signaling pathwayCellular component movementTyrosine-protein kinase JAK2Chemokine signaling pathwayAdipocytokine signaling pathway 3.30.200.20 93 23 92 2.22 2.40
1opjA01 86.71 Protein domain specific bindingNucleusPeptidyl-tyrosine phosphorylationManganese ion bindingMus musculus 3.30.200.20 94 19 90 3.05 3.37
2i6lA01 86.54 Protein phosphorylationMitogen-activated protein kinase 6Homo sapiensSignal transductionMitogen-activated protein kinase 4/6 [EC:2.7.11.24] 3.30.200.20 91 20 87 3.92 4.50
3g51A01 86.34 Progesterone-mediated oocyte maturationNeurotrophin signaling pathwayOocyte meiosisMAPK signaling pathwayLong-term potentiation 3.30.200.20 95 31 83 2.93 3.52
1s9jA01 86.33 Prion diseasesNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 3.30.200.20 86 18 90 3.54 3.92
2ac3A01 86.29 MAP kinase-interacting serine/threonine-protein kinase 2ATP bindingProtein phosphorylationHomo sapiensProtein serine/threonine kinase activity 3.30.200.20 80 27 83 1.77 2.11
1fmkA03 86.18 Epithelial cell signaling in Helicobacter pylori infectionPositive regulation of integrin activationRegulation of bone resorptionProto-oncogene tyrosine-protein kinase SrcErbB signaling pathway 3.30.200.20 86 26 92 2.78 3.01
1xbbA01 86.07 T cell receptor complexTyrosine-protein kinase SYKOrgan morphogenesisLeukocyte cell-cell adhesionCell proliferation 3.30.200.20 83 22 86 2.34 2.72
1qpcA01 86.02 Pericentriolar materialPhosphoinositide 3-kinase bindingCD8 receptor bindingT cell receptor signaling pathwayCD4 receptor binding 3.30.200.20 88 22 89 2.30 2.58
3hmmA01 85.86 Type II transforming growth factor beta receptor bindingPeptidyl-threonine phosphorylationPositive regulation of cellular component movementPathway-restricted SMAD protein phosphorylationResponse to cholesterol 3.30.200.20 84 19 83 1.93 2.30
1lufA01 85.78 Muscle, skeletal receptor tyrosine protein kinaseReceptor clusteringRattus norvegicusResponse to muscle activityMemory 3.30.200.20 97 20 89 2.31 2.58
3fhrA01 85.77 Response to stressMAP kinase kinase activityNucleusMitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]MAPK signaling pathway 3.30.200.20 80 17 81 2.12 2.59
2r3iA01 85.76 Progesterone-mediated oocyte maturationPathways in cancerSmall cell lung cancerOocyte meiosisProstate cancer 3.30.200.20 76 28 81 2.47 3.02
3cc6A01 85.32 Calcium signaling pathwayChemokine signaling pathwayPositive regulation of cell proliferationProtein-tyrosine kinase 2-betaLeukocyte transendothelial migration 3.30.200.20 90 24 92 2.23 2.41
3a8xB01 85.20 Tight junctionInsulin signaling pathwayEndocytosisVesicle-mediated transportProtein binding 3.30.200.20 130 30 68 1.99 2.91
2oibA01 85.03 Chagas diseaseNeurotrophin signaling pathwayInterleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]ApoptosisHomo sapiens 3.30.200.20 93 16 83 2.52 3.00
1kobA01 85.02 Aplysia californicaTwitchin-like protein 3.30.200.20 109 21 80 3.02 3.74
2qkwB01 84.91 Solanum pimpinellifoliumProtein kinaseProtein binding 3.30.200.20 72 18 77 1.80 2.33
1ob3A01 84.59 Cyclin-dependent kinase [EC:2.7.11.22]Cell division control protein 2 homologPlasmodium falciparum K1 3.30.200.20 83 19 88 3.24 3.67
3c4cA01 84.42 Neurotrophin signaling pathwayNon-small cell lung cancerCytoplasmErbB signaling pathwayProtein phosphorylation 3.30.200.20 86 16 92 3.68 3.98
3bceA01 84.32 Receptor tyrosine-protein kinase erbB-4Transmembrane receptor protein tyrosine kinase activityHomo sapiensBasolateral plasma membraneProtein binding 3.30.200.20 94 23 89 2.63 2.94
2w5aA01 84.19 NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]Regulation of mitosisSerine/threonine-protein kinase Nek2CentrosomeCentrosome separation 3.30.200.20 64 21 66 1.45 2.17
2rgpA01 84.19 Calcium signaling pathwayPositive regulation of nitric oxide biosynthetic processEpidermal growth factor receptor activityResponse to UV-APositive regulation of cyclin-dependent protein kinase activity involved in G1/S 3.30.200.20 82 25 87 3.77 4.33
2f57B01 83.59 T cell receptor signaling pathwayP21-activated kinase 7 [EC:2.7.11.1]Protein bindingRenal cell carcinomaErbB signaling pathway 3.30.200.20 106 19 80 2.58 3.22
1fvrA01 83.22 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 86 22 88 3.31 3.75
2oo8X01 82.48 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 60 25 63 2.10 3.31
3h9rA01 82.12 Positive regulation of osteoblast differentiationBMP signaling pathwayActivin bindingNegative regulation of apoptosisNegative regulation of activin receptor signaling pathway 3.30.200.20 113 13 73 2.42 3.29
1ckiA01 81.97 SpindleRattus norvegicusHedgehog signaling pathwaySoluble fractionCircadian rhythm - mammal 3.30.200.20 64 18 67 1.87 2.76
1nd4A01 80.26 Aminoglycoside 3'-phosphotransferaseKlebsiella pneumoniae 3.30.200.20 86 9 82 4.00 4.83
3g0eA01 80.19 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Protein bindingAcute myeloid leukemia 3.30.200.20 131 22 66 2.54 3.82
2bkkA01 80.06 Aminoglycoside 3'-phosphotransferaseAminoglycoside 3'-phosphotransferase [EC:2.7.1.95]Enterococcus faecalis 3.30.200.20 90 14 88 4.33 4.91
2vd5B01 79.41 ATP bindingRegulation of heart contractionProtein phosphorylationHomo sapiensProtein serine/threonine kinase activity 3.30.200.20 187 32 49 2.35 4.73
2f2uB01 79.22 Chemokine signaling pathwayRho-associated, coiled-coil containing protein kinase [EC:2.7.11.1]Leukocyte transendothelial migrationWnt signaling pathwayTGF-beta signaling pathway 3.30.200.20 184 34 50 2.52 4.99
3dzoA02 77.64 Toxoplasma gondiiRop2 protein 3.30.200.20 118 12 66 3.03 4.53
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Displaying entries 1 to 63 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1uu3A02
QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDD
EKLYFGLSYAKNG
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1uu3A02
QPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDD
EKLYFGLSYAKNG
BLAST against CATH

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Domain History Events (2)

Domain assigned by lewis on 18 Jan 2007 20:37

Reassigning this domain to its previous classification as part of fragment fixing process in preparation for release v3.1.0.

Insertion by lewis on 18 Jan 2007 20:37

Rechopping chains just before release v3.1.0 in order to fix missing fragments.