CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Hemagglutinin-neuraminidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P32884
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P32884
HN_NDVB
Newcastle disease virus strain Beaudette C/45
Hemagglutinin-neuraminidase

PDB Structure

PDB 1USX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Second Sialic Acid Binding Site in Newcastle Disease Virus Hemagglutinin-Neuraminidase: Implications for Fusion
Zaitsev, V., Von Itzstein, M., Groves, D., Kiefel, M., Takimoto, T., Portner, A., Taylor, G.
J.Virol.