CATH Domain: 1upqA00 XML data for domain: 1upqA00

Molscript image for 1upqA00
1upqA00
PDB coordinates for domain 1upqA00

PDB 1upq, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.4
2.30.29.30.4.1
2.30.29.30.4.1.1
2.30.29.30.4.1.1.1
2.30.29.30.4.1.1.1.1

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Segment boundaries for domain 1upqA00

Chopping figure for domain 1upqA00
DomainStart PDB ResidueStop PDB Residue
1upqA00 47 153

Structural Neighbourhood (37 entries)

There are 37 matching structural neighberhood comparisons for CATH ID 2.30.29.30.4.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 37 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1faoA00 89.71 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 25 90 2.11 2.33
1eazA00 89.34 NucleusPleckstrin homology domain-containing family A member 1B cell receptor signaling pathwayPhosphatidylinositol-3,4-bisphosphate bindingRuffle organization 2.30.29.30 103 24 92 1.79 1.93
2i5fA00 88.78 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayActin cytoskeleton reorganizationHemopoietic progenitor cell differentiationRuffle organization 2.30.29.30 92 25 85 1.92 2.26
1u5dA00 88.71 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 20 93 2.47 2.64
3cxbB00 88.48 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 21 88 1.83 2.06
1btnA00 87.23 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 16 86 2.16 2.49
2dn6A00 87.21 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 18 88 4.11 4.63
1qqgA01 86.64 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 22 84 1.65 1.96
1v89A00 86.55 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 27 88 3.81 4.28
1omwA05 86.17 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 18 85 2.17 2.52
1dynA00 85.52 GTPase activityReceptor-mediated endocytosisHomo sapiensDynamin-1Protein binding 2.30.29.30 113 21 86 2.55 2.94
1txdA02 84.05 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 11 81 2.55 3.12
1ntyA02 83.99 Triple functional domain protein [EC:2.7.11.-]Triple functional domain proteinHomo sapiensProtein serine/threonine kinase activityTransmembrane receptor protein tyrosine phosphatase signaling pathway 2.30.29.30 124 12 83 2.93 3.53
1zsqA01 83.78 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 8 90 3.38 3.73
1plsA00 83.59 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 21 89 2.81 3.14
1t77A01 83.32 Lipopolysaccharide-responsive and beige-like anchor proteinHomo sapiensProtein binding 2.30.29.40 105 8 83 4.00 4.81
1ddwA00 83.13 DendriteType 5 metabotropic glutamate receptor bindingRattus norvegicusResponse to cocaineResponse to stress 2.30.29.30 109 3 84 2.85 3.38
1qqgA02 83.05 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 9 85 2.87 3.37
2p8vA00 82.73 Homer protein homolog 3Metabotropic glutamate receptor signaling pathwayProtein targetingHomo sapiensProtein binding 2.30.29.30 117 3 81 3.12 3.84
1evhA00 82.25 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 7 83 2.88 3.44
2he7A03 81.88 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 7 78 2.40 3.06
2coaA01 81.87 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 16 81 2.66 3.27
1ef1A03 81.87 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 11 79 2.21 2.78
1dbhA02 81.80 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 13 78 3.04 3.89
2rgnB02 81.64 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 10 76 2.44 3.19
1kz7C02 81.21 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 14 74 2.92 3.91
1pfjA00 81.09 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 5 87 3.49 3.97
1w1hD00 80.79 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 18 68 2.94 4.28
1p5tA00 80.60 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity 2.30.29.30 105 10 80 3.39 4.22
1btkA00 80.26 Induction of apoptosis by extracellular signalsPhosphatidylinositol-3,4,5-trisphosphate bindingIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.29.30 160 17 61 2.08 3.36
1rrpB00 79.90 E3 SUMO-protein ligase RanBP2Ran GTPase bindingNuclear poreProtein import into nucleusHomo sapiens 2.30.29.30 134 5 75 3.18 4.22
1mixA02 79.68 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 9 81 2.89 3.55
1xr0B01 79.16 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 8 75 2.70 3.57
1ki1B02 78.60 Synaptic vesicle endocytosisHomo sapiensProtein bindingIntersectin-1 2.30.29.30 142 15 67 2.91 4.30
1q67A01 78.55 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 5 66 3.24 4.88
3f5rA00 78.43 DNA-dependent DNA replicationPositive regulation of RNA polymerase II transcriptional preinitiation complex assemblyDNA replication-independent nucleosome organizationProtein bindingFACT complex subunit POB3 2.30.29.30 107 5 82 2.99 3.64
1aqcB00 78.12 Nervous system developmentSynaptic transmissionCell adhesionAmyloid beta (A4) precursor protein-binding, family A, member 1 (X11)Axon cargo transport 2.30.29.30 114 8 71 3.21 4.46
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Displaying entries 1 to 37 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1upqA00
LRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAEHP
GMRTYVLAADTLEDLRGWLRALGRASR
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1upqA00
NALRRDPNLPVHIRGWLHKQDSSGLRLWKRRWFVLSGHCLFYYKDSREESVLGSVLLPSYNIRPDGPGAPRGRRFTFTAE
HPGMRTYVLAADTLEDLRGWLRALGRASRAEGDDYGQPRSPAR
BLAST against CATH

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Domain History Events (3)

Insertion by sillitoe on 06 Mar 2006 15:40

HomCheck 'Assigned H' domains

Flow stage update by sillitoe on 06 Mar 2006 15:40

HomCheck 'Assigned H' domains

Insertion by auto on 06 Mar 2006 00:00

Cut based on decision in database "DomChop" on "cathdb"