CATH Domain: 1unqA00 XML data for domain: 1unqA00

Molscript image for 1unqA00
1unqA00
PDB coordinates for domain 1unqA00

PDB 1unq, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.1
2.30.29.30.1.1
2.30.29.30.1.1.1
2.30.29.30.1.1.1.1
2.30.29.30.1.1.1.1.1

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Segment boundaries for domain 1unqA00

Chopping figure for domain 1unqA00
DomainStart PDB ResidueStop PDB Residue
1unqA00 0 117

Structural Neighbourhood (39 entries)

There are 39 matching structural neighberhood comparisons for CATH ID 2.30.29.30.1.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 39 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1faoA00 87.66 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 22 83 2.59 3.09
1eazA00 87.61 NucleusPleckstrin homology domain-containing family A member 1B cell receptor signaling pathwayPhosphatidylinositol-3,4-bisphosphate bindingRuffle organization 2.30.29.30 103 23 83 1.85 2.21
1u5dA00 87.37 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 17 84 2.18 2.58
2dn6A00 87.02 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 18 91 2.25 2.46
1upqA00 86.89 Pleckstrin homology domain-containing family A member 4Homo sapiens 2.30.29.30 107 19 85 2.35 2.75
1v89A00 86.53 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 20 89 2.46 2.74
2i5fA00 86.28 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayActin cytoskeleton reorganizationHemopoietic progenitor cell differentiationRuffle organization 2.30.29.30 92 28 78 2.13 2.71
1fgyA00 86.21 RufflePhosphatidylinositol-3,4,5-trisphosphate bindingCytohesin-3Plasma membraneProtein binding 2.30.29.30 125 21 84 3.38 3.99
1qqgA01 85.99 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 14 79 1.50 1.89
1btnA00 85.51 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 16 79 1.96 2.47
3cxbB00 85.42 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 18 81 2.04 2.51
1txdA02 85.38 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 12 91 3.61 3.94
2rgnB02 84.81 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 9 86 3.08 3.57
2dhjA00 84.78 Rho GTPase-activating protein 21Homo sapiens 2.30.29.30 125 23 88 3.46 3.90
1omwA05 84.53 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 14 85 2.98 3.49
1plsA00 84.19 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 21 90 3.20 3.53
2p8vA00 83.93 Homer protein homolog 3Metabotropic glutamate receptor signaling pathwayProtein targetingHomo sapiensProtein binding 2.30.29.30 117 8 88 2.52 2.86
1qqgA02 83.88 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 11 82 2.77 3.34
1kz7C02 83.50 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 13 82 4.03 4.91
2he7A03 82.97 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 8 77 2.32 2.98
1ddwA00 82.88 DendriteType 5 metabotropic glutamate receptor bindingRattus norvegicusResponse to cocaineResponse to stress 2.30.29.30 109 5 82 2.65 3.23
1evhA00 82.86 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 6 82 2.88 3.51
1zsqA01 82.76 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 7 79 3.55 4.47
1xodB00 82.63 Jak-STAT signaling pathwaySprouty-related, EVH1 domain containingXenopus (Silurana) tropicalisSprouty-related, EVH1 domain-containing protein 1 2.30.29.30 118 6 83 3.42 4.08
1w1hD00 82.46 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 13 70 2.67 3.77
1v88A00 82.24 Oxysterol-binding protein-related protein 8Homo sapiens 2.30.29.30 130 15 83 3.64 4.38
2coaA01 81.86 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 11 83 3.21 3.83
1aqcB00 81.79 Nervous system developmentSynaptic transmissionCell adhesionAmyloid beta (A4) precursor protein-binding, family A, member 1 (X11)Axon cargo transport 2.30.29.30 114 7 77 3.11 4.00
1dbhA02 81.68 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 13 80 3.66 4.54
1ef1A03 81.18 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 8 80 2.68 3.34
1rrpB00 80.90 E3 SUMO-protein ligase RanBP2Ran GTPase bindingNuclear poreProtein import into nucleusHomo sapiens 2.30.29.30 134 9 76 3.32 4.32
1p5tA00 80.80 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity 2.30.29.30 105 9 82 3.62 4.37
1ki1B02 80.04 Synaptic vesicle endocytosisHomo sapiensProtein bindingIntersectin-1 2.30.29.30 142 15 75 3.71 4.92
1ntvA00 79.80 Radial glia guided migration of Purkinje cellDisabled homolog 1Cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migrationNegative regulation of cell adhesionMus musculus 2.30.29.30 152 7 70 3.34 4.74
1q67A01 79.57 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 6 68 3.27 4.77
1pfjA00 79.03 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 9 84 3.53 4.17
1mixA02 78.52 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 11 79 3.73 4.69
1xr0B01 78.44 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 9 75 3.05 4.06
1ddmA00 76.80 Notch signaling pathwaySensory organ precursor cell fate determinationSensory organ precursor cell divisionProtein localizationDrosophila melanogaster 2.30.29.30 135 6 75 3.76 4.98
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Displaying entries 1 to 39 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1unqA00
SMSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCLQ
WTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEE
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1unqA00
XSMSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQREAPLNNFSVAQCQLMKTERPRPNTFIIRCL
QWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDFRSG
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:23

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:23

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 14:47

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"