CATH Domain: 1txdA02 XML data for domain: 1txdA02

Molscript image for 1txdA02
1txdA02
PDB coordinates for domain 1txdA02

PDB 1txd, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.15
2.30.29.30.15.1
2.30.29.30.15.1.1
2.30.29.30.15.1.1.1
2.30.29.30.15.1.1.1.1

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Segment boundaries for domain 1txdA02

Chopping figure for domain 1txdA02
DomainStart PDB ResidueStop PDB Residue
1txdA01 766 996
1txdA02 997 1138

Structural Neighbourhood (22 entries)

There are 22 matching structural neighberhood comparisons for CATH ID 2.30.29.30.15.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 22 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2rgnB02 85.72 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 13 82 1.95 2.35
1omwA05 85.29 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 10 79 2.09 2.63
1kz7C02 84.85 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 12 81 3.61 4.44
1v89A00 84.45 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 16 88 3.50 3.96
1faoA00 84.33 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 13 78 3.00 3.82
1ki1B02 83.86 Synaptic vesicle endocytosisHomo sapiensProtein bindingIntersectin-1 2.30.29.30 142 22 76 2.43 3.17
1qqgA02 83.81 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 6 79 2.84 3.58
3cxbB00 83.57 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 17 76 1.86 2.45
1qqgA01 83.24 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 9 76 3.40 4.47
1zsqA01 83.14 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 5 75 2.92 3.88
1btnA00 83.01 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 10 74 2.78 3.74
1dbhA02 82.96 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 9 81 2.61 3.20
2he7A03 82.65 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 2 75 2.02 2.69
1plsA00 82.15 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 16 83 3.16 3.79
2coaA01 81.47 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 15 78 2.85 3.63
1ef1A03 81.14 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 10 76 2.73 3.55
1p5tA00 80.61 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity 2.30.29.30 105 7 77 3.35 4.31
1pfjA00 80.14 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 11 80 3.87 4.78
1btkA00 79.87 Induction of apoptosis by extracellular signalsPhosphatidylinositol-3,4,5-trisphosphate bindingIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.29.30 160 9 61 2.95 4.77
1aqcB00 79.82 Nervous system developmentSynaptic transmissionCell adhesionAmyloid beta (A4) precursor protein-binding, family A, member 1 (X11)Axon cargo transport 2.30.29.30 114 2 72 2.69 3.70
1mixA02 79.21 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 8 75 3.18 4.23
1xr0B01 78.19 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 5 71 3.20 4.45
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Displaying entries 1 to 22 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1txdA02
SSLVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCTFSPVIKLSTVLVRQVATNKAL
FVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQS
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1txdA02
SSLKLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVLRCHSKILASTADSKHTF
SPVIKLSTVLVRQVATDNKALFVISMSDNGAQIYELVAQTVSEKTVWQDLICRMAASVKEQSVDGGHHHHHH
BLAST against CATH

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Domain History Events (3)

Insertion by sillitoe on 06 Mar 2006 15:40

HomCheck 'Assigned H' domains

Flow stage update by sillitoe on 06 Mar 2006 15:40

HomCheck 'Assigned H' domains

Insertion by auto on 05 Mar 2006 23:56

Cut based on decision in database "DomChop" on "cathdb"