CATH Classification

Domain Context

CATH Clusters

Superfamily DNA mismatch repair MutH/Restriction endonuclease, type II
Functional Family

Enzyme Information

3.1.21.4
Type II site-specific deoxyribonuclease.
based on mapping to UniProt P17743
Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.
-!- Large group of enzymes which recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition site. -!- See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

UniProtKB Entries (1)

P17743
T2C2_HAEIF
Haemophilus influenzae
Type-2 restriction enzyme HincII

PDB Structure

PDB 1TX3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Ca2+ binding in the active site of HincII: implications for the catalytic mechanism
Etzkorn, C., Horton, N.C.
Biochemistry