CATH Domain: 1sshA00 XML data for domain: 1sshA00

Molscript image for 1sshA00
1sshA00
PDB coordinates for domain 1sshA00

PDB 1ssh, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.10
2.30.30.40.10.1
2.30.30.40.10.1.1
2.30.30.40.10.1.1.1
2.30.30.40.10.1.1.1.1

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Segment boundaries for domain 1sshA00

Chopping figure for domain 1sshA00
DomainStart PDB ResidueStop PDB Residue
1sshA00 1 60

Structural Neighbourhood (62 entries)

There are 62 matching structural neighberhood comparisons for CATH ID 2.30.30.40.10.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 62 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vwfA00 93.58 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 42 91 1.22 1.33
1w70A00 93.45 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 36 96 2.40 2.48
3i9qA00 92.07 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 33 93 1.60 1.71
2ak5B00 91.92 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 36 90 1.92 2.12
1jo8A00 91.87 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 37 91 1.62 1.77
1ckaA00 91.55 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 35 91 1.92 2.09
3h0hA00 91.42 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 38 92 1.86 2.02
2jteA00 91.12 Mus musculusCD2-associated protein 2.30.30.40 64 31 93 2.80 2.99
1ov3A02 91.12 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 22 90 1.62 1.80
2j6fA00 90.96 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 29 93 2.13 2.28
3i35A00 90.87 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 30 91 1.70 1.85
1yn8A00 90.39 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 27 93 2.22 2.38
1ad5A01 90.13 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 36 88 2.10 2.36
1zuyA00 89.99 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 34 91 1.91 2.08
2rqtA00 89.70 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 25 91 2.00 2.18
2v1rA00 89.67 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 36 89 4.04 4.51
2ablA01 89.51 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 25 89 2.71 3.03
1x6bA01 89.25 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 20 87 1.99 2.27
3ehrB01 89.15 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 33 91 2.44 2.65
2js2A00 89.10 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 25 90 3.67 4.06
1griA01 89.01 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 33 80 2.12 2.65
2vknA00 88.96 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 26 86 2.33 2.70
2csqA01 88.84 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 25 87 2.35 2.68
1ycsB02 88.77 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 30 93 2.93 3.13
1jegA00 88.56 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 41 96 2.84 2.94
1wx6A01 88.37 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 25 90 3.21 3.53
1gcqC00 88.34 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 26 85 2.83 3.31
1ng2A02 87.97 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 20 83 3.00 3.58
1j3tA00 87.59 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 36 77 2.49 3.23
1uhfA00 87.22 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 38 82 2.87 3.47
1awwA00 86.57 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 38 86 2.22 2.56
1spkA00 86.14 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 26 81 2.45 2.99
2epdA00 85.66 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 35 76 2.62 3.43
2ke9A00 85.48 Caskin-2Homo sapiens 2.30.30.40 67 35 85 2.33 2.74
1tucA00 84.65 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 61 26 72 3.51 4.87
1ng2A01 84.65 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 20 73 2.72 3.71
3i5rA00 84.16 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 28 74 2.59 3.50
1u3oA01 83.17 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 21 91 3.47 3.77
1jxmA01 82.17 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 30 66 2.77 4.18
2heqA01 81.79 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 11 88 3.62 4.10
1sf9A02 81.68 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 11 73 2.66 3.63
1udlA00 81.24 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 98 36 59 2.64 4.46
1mhnA00 80.97 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 8 83 3.34 4.01
2rh2A00 80.21 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 10 80 3.61 4.51
2g3rA01 80.15 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 11 80 3.19 3.99
2aklA02 79.72 Phosphonate and phosphinate metabolismPseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Putative uncharacterized protein 2.30.30.40 73 10 78 3.24 4.15
2o2oA00 79.04 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 23 77 2.33 3.01
1jb0E00 78.80 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 13 75 3.42 4.54
1biaA03 77.85 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 6 78 3.75 4.79
1ri9A00 77.84 FYN-binding proteinProtein phosphorylationNucleusHomo sapiensImmune response 2.30.30.40 77 13 74 3.48 4.70
1ib8A02 77.25 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 13 76 3.18 4.18
1u1sA00 76.81 RNA degradationPseudomonas aeruginosaHost factor-I proteinProtein hfq 2.30.30.100 66 5 63 3.05 4.79
2vv5A02 76.80 Escherichia coli O157:H7Small conductance mechanosensitive ion channel, MscS familySmall-conductance mechanosensitive channel 2.30.30.60 50 14 70 3.15 4.50
1irxA02 76.40 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 6 70 3.09 4.41
1n9rB00 76.27 Protein bindingNuclear mRNA splicing, via spliceosomeSmall nuclear ribonucleoprotein FSmall nuclear ribonucleoprotein FU5 snRNP 2.30.30.100 69 10 71 3.41 4.80
1mgqF00 75.98 Methanothermobacter thermautotrophicus str. Delta HSmall nuclear ribonucleoproteinPutative snRNP Sm-like protein 2.30.30.100 70 1 65 3.14 4.78
1kq1H00 75.97 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 6 65 2.78 4.27
1awjA00 75.28 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 25 75 3.55 4.71
2hjqA01 74.78 Uncharacterized protein yqbFBacillus subtilis 3.40.5.20 46 17 68 3.15 4.61
1b34B00 72.69 SpliceosomeSpliceosomal complexSmall nuclear ribonucleoprotein Sm D2Homo sapiensSmall nuclear ribonucleoprotein D2 2.30.30.100 74 5 62 3.07 4.94
1ljoA00 72.60 Archaeoglobus fulgidusSnRNP, putative 2.30.30.100 75 6 60 2.96 4.93
1d3bC00 71.20 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D3Small nuclear ribonucleoprotein D3Spliceosomal complex 2.30.30.100 71 8 64 3.21 4.95
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Displaying entries 1 to 62 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1sshA00
GSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1sshA00
GSSPKAVALYSFAGEESGDLPFRKGDVITILKKSDSQNDWWTGRVNGREGIFPANYVELV
BLAST against CATH

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Domain History Events (5)

Domain assigned by auto on 28 Apr 2006 19:05

Assigning to "2.30.30.40" based on similarity with "1ootA00" (NWSI: 100, NWO: 100, SPS: 95.60, SPO: 96, RMSD: 1.01)

Flow stage update by auto on 28 Apr 2006 17:50

NW result present for Domain "1sshA00"

Flow stage update by auto on 28 Apr 2006 17:45

All required files are present for Domain "1sshA00"

Flow stage update by auto on 27 Apr 2006 17:31

Beginning processing for Domain "1sshA00"

Insertion by auto on 09 Mar 2006 05:07

Final ChopClose added based on similarity with "1ootA" [LEE: 2, LME: 0, MR: 0, LG: 2, SS: 95.60, SI: 100, SO: 100]