CATH Domain: 1qpcA01 XML data for domain: 1qpcA01

Molscript image for 1qpcA01
1qpcA01
PDB coordinates for domain 1qpcA01

PDB 1qpc, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.200 Phosphorylase Kinase; domain 1
3.30.200.20 Phosphorylase Kinase; domain 1 Gene3D
3.30.200.20.19
3.30.200.20.19.1
3.30.200.20.19.1.1
3.30.200.20.19.1.1.1
3.30.200.20.19.1.1.1.1

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Segment boundaries for domain 1qpcA01

Chopping figure for domain 1qpcA01
DomainStart PDB ResidueStop PDB Residue
1qpcA01 231 318
1qpcA02 319 499

Structural Neighbourhood (51 entries)

There are 51 matching structural neighberhood comparisons for CATH ID 3.30.200.20.19.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 51 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1xbbA01 89.50 T cell receptor complexTyrosine-protein kinase SYKOrgan morphogenesisLeukocyte cell-cell adhesionCell proliferation 3.30.200.20 83 37 89 1.88 2.09
1lufA01 87.96 Muscle, skeletal receptor tyrosine protein kinaseReceptor clusteringRattus norvegicusResponse to muscle activityMemory 3.30.200.20 97 30 90 2.31 2.55
3eqrB01 87.85 Activated CDC42 kinase 1GTPase inhibitor activitySmall GTPase mediated signal transductionHomo sapiensPositive regulation of peptidyl-tyrosine phosphorylation 3.30.200.20 91 36 91 2.44 2.68
3bceA01 87.77 Receptor tyrosine-protein kinase erbB-4Transmembrane receptor protein tyrosine kinase activityHomo sapiensBasolateral plasma membraneProtein binding 3.30.200.20 94 30 93 3.79 4.05
1tkiA01 87.61 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 3.30.200.20 84 19 90 2.79 3.07
3c4cA01 87.30 Neurotrophin signaling pathwayNon-small cell lung cancerCytoplasmErbB signaling pathwayProtein phosphorylation 3.30.200.20 86 26 92 2.59 2.81
2rgpA01 87.20 Calcium signaling pathwayPositive regulation of nitric oxide biosynthetic processEpidermal growth factor receptor activityResponse to UV-APositive regulation of cyclin-dependent protein kinase activity involved in G1/S 3.30.200.20 82 24 92 3.03 3.29
3e64A01 86.86 Jak-STAT signaling pathwayCellular component movementTyrosine-protein kinase JAK2Chemokine signaling pathwayAdipocytokine signaling pathway 3.30.200.20 93 30 90 2.45 2.71
3hmmA01 86.55 Type II transforming growth factor beta receptor bindingPeptidyl-threonine phosphorylationPositive regulation of cellular component movementPathway-restricted SMAD protein phosphorylationResponse to cholesterol 3.30.200.20 84 25 85 1.99 2.33
3comB01 86.32 Transcription factor bindingPathways in cancerNon-small cell lung cancerCytoplasmSerine/threonine-protein kinase 4 3.30.200.20 85 20 92 3.20 3.48
3blhA01 86.23 Transcription elongation from RNA polymerase II promoterCyclin-dependent protein kinase activityRNA polymerase II carboxy-terminal domain kinase activityProtein bindingCell proliferation 3.30.200.20 86 22 94 3.56 3.77
2evaA01 86.21 Positive regulation of T cell cytokine productionActivation of NF-kappaB-inducing kinase activityPositive regulation of interleukin-2 productionMitogen-activated protein kinase kinase kinase 7Protein binding 3.30.200.20 82 24 90 1.97 2.17
2wtkC01 86.07 NucleusSerine/threonine-protein kinase 11Cell cycle arrestProtein bindingSerine/threonine-protein kinase 11 [EC:2.7.11.9] 3.30.200.20 89 22 85 1.88 2.20
2acxA02 85.94 G protein-coupled receptor kinase 6Homo sapiensRegulation of G-protein coupled receptor protein signaling pathway 3.30.200.20 91 18 89 2.18 2.45
2j51A01 85.78 CytoplasmOocyte meiosisSTE20-like serine/threonine-protein kinasePlasma membraneHomo sapiens 3.30.200.20 90 18 92 2.73 2.96
2oibA01 85.77 Chagas diseaseNeurotrophin signaling pathwayInterleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]ApoptosisHomo sapiens 3.30.200.20 93 23 83 2.74 3.27
3f3zA01 85.72 Cryptosporidium parvum Iowa IICalcium-dependent protein kinase [EC:2.7.11.1]Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands 3.30.200.20 81 25 89 2.31 2.57
3c0iA01 85.70 Actin cytoskeletonGuanylate kinase activityPeripheral plasma membrane protein CASKCell adhesionHomo sapiens 3.30.200.20 88 19 90 2.46 2.71
2h6dA01 85.62 Insulin signaling pathwayHypertrophic cardiomyopathy (HCM)Adipocytokine signaling pathwayRegulation of autophagyMTOR signaling pathway 3.30.200.20 86 26 90 3.57 3.93
2zv2A01 85.52 Calcium ion bindingRegulation of protein kinase activityPositive regulation of transcriptionMAPKKK cascadeCytoplasm 3.30.200.20 77 24 82 2.70 3.25
1s9jA01 85.39 Prion diseasesNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 3.30.200.20 86 17 92 3.04 3.30
2r3iA01 85.37 Progesterone-mediated oocyte maturationPathways in cancerSmall cell lung cancerOocyte meiosisProstate cancer 3.30.200.20 76 27 81 2.37 2.90
1x8bA01 85.19 Homo sapiensWee1-like protein kinaseProtein binding 3.30.200.20 84 19 88 4.39 4.95
1fvrA01 85.18 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 86 19 92 3.93 4.27
2jamA01 85.11 Calcium/calmodulin-dependent protein kinase type 1GHomo sapiensCalcium/calmodulin-dependent protein kinase I [EC:2.7.11.17] 3.30.200.20 75 24 82 2.13 2.57
2dylA01 85.07 Mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]MAP kinase kinase activityNeurotrophin signaling pathwayStress-activated MAPK cascadeT cell receptor signaling pathway 3.30.200.20 91 11 84 2.96 3.50
2rkuA01 85.04 Polo-like kinase 1 [EC:2.7.11.21]Polo kinase kinase activityProgesterone-mediated oocyte maturationCell proliferationOocyte meiosis 3.30.200.20 89 13 88 2.08 2.34
2ac3A01 84.94 MAP kinase-interacting serine/threonine-protein kinase 2ATP bindingProtein phosphorylationHomo sapiensProtein serine/threonine kinase activity 3.30.200.20 80 18 85 1.96 2.30
2vgpB01 84.50 Serine/threonine-protein kinase 12-AHistone H3-S10 phosphorylationChromosome, centromeric regionProtein bindingChromatin 3.30.200.20 89 19 88 2.44 2.75
1ob3A01 84.47 Cyclin-dependent kinase [EC:2.7.11.22]Cell division control protein 2 homologPlasmodium falciparum K1 3.30.200.20 83 21 87 3.03 3.46
1zy4A01 84.38 Eukaryotic translation initiation factor 2alpha kinase activityProtein bindingSerine/threonine-protein kinase GCN2DNA damage checkpointRegulation of translational initiation 3.30.200.20 94 23 86 3.29 3.82
1u5qA01 84.21 Rattus norvegicusThousand and one amino acid protein kinase [EC:2.7.11.1]Serine/threonine-protein kinase TAO2MAPK signaling pathway 3.30.200.20 96 15 91 2.64 2.88
2clqA01 84.19 Induction of apoptosis by extracellular signalsProtein homodimerization activityMitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]Neurotrophin signaling pathwayATP binding 3.30.200.20 85 20 85 2.28 2.68
1xwsA01 83.79 Transcription factor bindingPositive regulation of cyclin-dependent protein kinase activity involved in G1/SManganese ion bindingNegative regulation of apoptosisProtein binding 3.30.200.20 92 20 85 2.64 3.07
1q5kA01 83.53 Hedgehog signaling pathwayNeurotrophin signaling pathwayAlzheimer's diseaseT cell receptor signaling pathwayER overload response 3.30.200.20 95 21 89 4.17 4.66
3fhrA01 83.40 Response to stressMAP kinase kinase activityNucleusMitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]MAPK signaling pathway 3.30.200.20 80 20 84 2.99 3.56
2qkwB01 83.10 Solanum pimpinellifoliumProtein kinaseProtein binding 3.30.200.20 72 26 77 1.75 2.26
3g0eA01 82.98 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Protein bindingAcute myeloid leukemia 3.30.200.20 131 35 67 2.90 4.32
3h9rA01 82.62 Positive regulation of osteoblast differentiationBMP signaling pathwayActivin bindingNegative regulation of apoptosisNegative regulation of activin receptor signaling pathway 3.30.200.20 113 23 75 3.37 4.48
2w5aA01 82.51 NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]Regulation of mitosisSerine/threonine-protein kinase Nek2CentrosomeCentrosome separation 3.30.200.20 64 23 67 2.15 3.21
1omwA03 82.22 MembraneG-protein coupled receptor kinase activityNegative regulation of the force of heart contraction by chemical signalChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 3.30.200.20 107 14 73 2.09 2.83
2f57B01 81.87 T cell receptor signaling pathwayP21-activated kinase 7 [EC:2.7.11.1]Protein bindingRenal cell carcinomaErbB signaling pathway 3.30.200.20 106 19 83 3.36 4.05
1nd4A01 81.82 Aminoglycoside 3'-phosphotransferaseKlebsiella pneumoniae 3.30.200.20 86 11 86 4.07 4.71
1o6lA02 81.36 Jak-STAT signaling pathwayRAC-beta serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.30.200.20 117 18 68 1.88 2.75
1ckiA01 81.31 SpindleRattus norvegicusHedgehog signaling pathwaySoluble fractionCircadian rhythm - mammal 3.30.200.20 64 17 69 2.47 3.56
2oo8X01 80.52 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 60 21 63 2.38 3.74
1rdqE02 80.29 Calcium signaling pathwayPrion diseasesProtein kinase A [EC:2.7.11.11]Olfactory transductionMesoderm formation 3.30.200.20 124 19 67 2.31 3.41
1kutB01 78.55 Thermotoga maritimaPhosphoribosylaminoimidazole-succinocarboxamide synthasePurine metabolismPhosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]Metabolic pathways 3.30.200.20 88 7 69 2.61 3.77
2jedB01 78.39 Protein kinase C theta typeProtein bindingT cell receptor signaling pathwayNovel protein kinase C [EC:2.7.11.13]Adipocytokine signaling pathway 3.30.200.20 125 20 63 2.19 3.47
3kreA01 76.62 Phosphoribosylaminoimidazole-succinocarboxamide synthasePurine metabolismPhosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]Ehrlichia chaffeensis str. ArkansasMetabolic pathways 3.30.200.20 94 6 65 3.15 4.78
2fstX01 76.31 Cellular component movementMAP kinase kinase activityProtein bindingChemotaxisMitogen-activated protein kinase 14 3.30.200.20 132 20 57 2.87 4.98
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Displaying entries 1 to 51 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1qpcA01
KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE
PIYIITEY
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1qpcA01
KPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE
PIYIITEY
BLAST against CATH

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Domain History Events (2)

Insertion by lewis on 18 Jan 2007 20:26

Rechopping chains just before release v3.1.0 in order to fix missing fragments.

Domain assigned by lewis on 18 Jan 2007 20:26

Reassigning this domain to its previous classification as part of fragment fixing process in preparation for release v3.1.0.