CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Fructose-bisphosphate aldolase

Enzyme Information

4.1.2.13
Fructose-bisphosphate aldolase.
based on mapping to UniProt P05062
D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.
-!- Also acts on (3S,4R)-ketose 1-phosphates. -!- The enzymes increase electron-attraction by the carbonyl group, some (Class I) forming a protonated imine with it, others (Class II), mainly of microbial origin, polarizing it with a metal ion, e.g. zinc. -!- Formerly EC 4.1.2.7.

UniProtKB Entries (1)

P05062
ALDOB_HUMAN
Homo sapiens
Fructose-bisphosphate aldolase B

PDB Structure

PDB 1QO5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of Human Liver Fructose-1,6-Bisphosphate Aldolase
Dalby, A.R., Tolan, D.R., Littlechild, J.A.
Acta Crystallogr.,Sect.D