CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrodipicolinate Reductase; domain 2
Functional Family Glucose-6-phosphate 1-dehydrogenase

Enzyme Information

1.1.1.49
Glucose-6-phosphate dehydrogenase (NADP(+)).
based on mapping to UniProt P11413
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH.
-!- The enzyme catalyzes a step of the pentose phosphate pathway. -!- The enzyme is specific for NADP(+), cf. EC 1.1.1.363 and EC 1.1.1.388.

UniProtKB Entries (1)

P11413
G6PD_HUMAN
Homo sapiens
Glucose-6-phosphate 1-dehydrogenase

PDB Structure

PDB 1QKI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Glucose-6-Phosphate Dehydrogenase: The Crystal Structure Reveals a Structural Nadp+ Molecule and Provides Insights Into Enzyme Deficiency
Au, S.W.N., Gover, S., Lam, V.M.S., Adams, M.J.
Structure