CATH Domain: 1opkA01 XML data for domain: 1opkA01

Molscript image for 1opkA01
1opkA01
PDB coordinates for domain 1opkA01

PDB 1opk, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.8
2.30.30.40.8.1
2.30.30.40.8.1.2
2.30.30.40.8.1.2.1
2.30.30.40.8.1.2.1.1

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Segment boundaries for domain 1opkA01

Chopping figure for domain 1opkA01
DomainStart PDB ResidueStop PDB Residue
1opkA01 83 145
1opkA02 146 247
1opkA03 259 344
1opkA04 345 519

Structural Neighbourhood (46 entries)

There are 46 matching structural neighberhood comparisons for CATH ID 2.30.30.40.8.1.2.1.1 (SIMAX score < 5)

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Displaying entries 1 to 46 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2ablA01 93.78 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 96 93 1.57 1.67
1yn8A00 91.08 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 25 90 1.67 1.85
1ov3A02 90.98 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 20 85 1.35 1.58
3i9qA00 90.82 Spectrin alpha chain, brainGallus gallusSpectrin alpha 2.30.30.40 57 31 90 1.54 1.71
1w70A00 90.72 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 2.30.30.40 60 18 95 3.26 3.43
1ckaA00 90.65 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 2.30.30.40 56 25 87 1.31 1.50
2ak5B00 90.38 Rattus norvegicusFocal adhesionProtein bindingGrowth coneCytoplasm 2.30.30.40 64 24 95 2.64 2.77
1sshA00 90.34 Cellular bud neckIdentical protein bindingActin cortical patch localizationSaccharomyces cerevisiaeMitochondrion 2.30.30.40 60 23 93 2.52 2.69
3i35A00 90.33 Focal adhesionHomo sapiensLIM and SH3 domain protein 1SH3/SH2 adaptor activity 2.30.30.40 56 17 87 1.24 1.42
2vwfA00 90.18 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 26 88 1.17 1.32
1ad5A01 89.98 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 33 90 1.69 1.87
3h0hA00 89.80 T cell receptor signaling pathwayLearningPrion diseasesFeeding behaviorTyrosine-protein kinase Fyn 2.30.30.40 63 37 95 3.09 3.24
2j6fA00 89.77 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 22 90 1.62 1.79
1jo8A00 89.38 Actin cortical patch assemblyMating projection tipActin-binding proteinEstablishment of cell polarityProtein localization 2.30.30.40 58 24 88 1.61 1.81
2js2A00 89.32 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 32 93 2.97 3.17
2jteA00 89.31 Mus musculusCD2-associated protein 2.30.30.40 64 11 95 3.92 4.11
1zuyA00 89.21 Identical protein bindingMating projection tipReceptor-mediated endocytosisActin cortical patch localizationResponse to salt stress 2.30.30.40 58 31 87 1.65 1.89
2v1rA00 89.05 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 27 89 3.34 3.73
1ycsB02 88.96 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 19 93 3.17 3.38
2vknA00 88.81 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 25 89 3.72 4.16
2rqtA00 88.64 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 21 91 1.67 1.82
3ehrB01 88.44 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 19 91 2.72 2.96
1wx6A01 88.42 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 22 90 2.51 2.76
1x6bA01 88.36 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 14 89 1.83 2.05
1jegA00 88.28 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 21 93 1.84 1.97
2csqA01 88.24 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 19 86 1.97 2.29
1griA01 87.44 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 33 75 1.16 1.53
1uhfA00 87.31 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 25 86 2.70 3.10
1gcqC00 86.92 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 12 86 3.38 3.89
1awwA00 86.35 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 30 91 4.43 4.87
1j3tA00 86.03 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 24 81 2.75 3.39
1spkA00 85.16 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 17 86 3.23 3.75
2ke9A00 84.70 Caskin-2Homo sapiens 2.30.30.40 67 17 86 3.10 3.58
1u3oA01 84.32 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 27 90 4.41 4.88
3i5rA00 84.28 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 17 75 3.74 4.97
1ng2A01 83.60 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 15 69 2.18 3.14
2heqA01 82.30 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 9 83 3.30 3.93
2hbwA01 81.72 Anabaena variabilis ATCC 29413NLP/P60 2.30.30.40 72 14 76 3.12 4.08
1ug1A00 81.64 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 20 67 2.87 4.26
1jxmA01 81.46 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 22 67 2.81 4.16
1uffA00 80.91 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 20 65 2.74 4.18
1jb0E00 80.64 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 6 76 3.70 4.82
1igqB00 80.49 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 5 77 3.72 4.80
1biaA03 78.17 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 6 75 3.50 4.62
1irxA02 77.36 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 6 64 2.78 4.31
1awjA00 76.46 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 27 77 3.00 3.85
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Displaying entries 1 to 46 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1opkA01
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1opkA01
NLFVALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVPSNYITPVNSLEKHS
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:24

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:24

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 17:27

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"