CATH Classification

Domain Context

CATH Clusters

Superfamily Cyclophilin-like
Functional Family Peptidyl-prolyl cis-trans isomerase A

Enzyme Information

5.2.1.8
Peptidylprolyl isomerase.
based on mapping to UniProt P62937
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

P62937
PPIA_HUMAN
Homo sapiens
Peptidyl-prolyl cis-trans isomerase A

PDB Structure

PDB 1OCA
External Links
Method SOLUTION NMR
Organism Escherichia
Primary Citation
The NMR solution conformation of unligated human cyclophilin A.
Ottiger, M., Zerbe, O., Guntert, P., Wuthrich, K.
J.Mol.Biol.