CATH Domain: 1ntyA02 XML data for domain: 1ntyA02

Molscript image for 1ntyA02
1ntyA02
PDB coordinates for domain 1ntyA02

PDB 1nty, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.8
2.30.29.30.8.1
2.30.29.30.8.1.1
2.30.29.30.8.1.1.1
2.30.29.30.8.1.1.1.1

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Segment boundaries for domain 1ntyA02

Chopping figure for domain 1ntyA02
DomainStart PDB ResidueStop PDB Residue
1ntyA01 1231 1411
1ntyA02 1412 1535

Structural Neighbourhood (26 entries)

There are 26 matching structural neighberhood comparisons for CATH ID 2.30.29.30.8.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 26 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1kz7C02 91.02 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 33 88 1.83 2.08
2rgnB02 87.44 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 30 82 2.91 3.54
1txdA02 87.19 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 13 90 4.36 4.83
1u5dA00 85.84 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 12 81 2.28 2.80
1faoA00 85.12 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 16 78 2.78 3.55
1dbhA02 85.03 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 18 87 2.81 3.20
3cxbB00 84.62 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 10 76 2.31 3.02
2dn6A00 84.61 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 13 82 3.99 4.85
1v89A00 83.85 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 13 86 3.47 4.02
2i5fA00 83.82 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayActin cytoskeleton reorganizationHemopoietic progenitor cell differentiationRuffle organization 2.30.29.30 92 15 74 2.07 2.79
1dynA00 83.80 GTPase activityReceptor-mediated endocytosisHomo sapiensDynamin-1Protein binding 2.30.29.30 113 14 83 3.43 4.09
1qqgA02 83.71 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 14 78 3.09 3.95
1omwA05 83.35 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 18 76 3.00 3.92
1qqgA01 82.60 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 10 70 2.08 2.96
1plsA00 82.54 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 11 79 2.28 2.88
1ddwA00 82.14 DendriteType 5 metabotropic glutamate receptor bindingRattus norvegicusResponse to cocaineResponse to stress 2.30.29.30 109 8 78 3.54 4.53
1w1hD00 82.13 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 18 72 2.65 3.63
2he7A03 81.95 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 10 72 3.23 4.45
1evhA00 81.84 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 9 78 3.06 3.91
1zsqA01 81.76 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 6 75 3.26 4.35
1btkA00 81.46 Induction of apoptosis by extracellular signalsPhosphatidylinositol-3,4,5-trisphosphate bindingIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.29.30 160 12 64 2.33 3.62
2coaA01 81.10 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 10 77 2.82 3.64
1ef1A03 80.41 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 13 71 2.33 3.25
1mixA02 79.69 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 11 74 3.65 4.92
1pfjA00 79.65 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 7 77 3.39 4.38
1q67A01 79.48 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 8 73 3.63 4.93
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Displaying entries 1 to 26 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1ntyA02
SMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEG
DPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERT
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1ntyA02
SMLEGFDENIESQGELILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVTEHVEG
DPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVIQERT
BLAST against CATH

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Domain History Events (3)

Insertion by sillitoe on 06 Mar 2006 15:40

HomCheck 'Assigned H' domains

Flow stage update by sillitoe on 06 Mar 2006 15:40

HomCheck 'Assigned H' domains

Insertion by auto on 05 Mar 2006 23:29

Cut based on decision in database "DomChop" on "cathdb"