CATH Classification

Domain Context

CATH Clusters

Superfamily Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Functional Family Kalirin RhoGEF kinase b

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O75962
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O75962
TRIO_HUMAN
Homo sapiens
Triple functional domain protein

PDB Structure

PDB 1NTY
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor trio in binding to phospholipids.
Skowronek, K.R., Guo, F., Zheng, Y., Nassar, N.
J.Biol.Chem.