CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P03472
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (2)

P01865
GCAM_MOUSE
Mus musculus
Ig gamma-2A chain C region, membrane-bound form
P03472
NRAM_I75A5
Influenza A virus (A/tern/Australia/G70C/1975(H11N9))
Neuraminidase

PDB Structure

PDB 1NCA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complex.
Tulip, W.R., Varghese, J.N., Laver, W.G., Webster, R.G., Colman, P.M.
J.Mol.Biol.