CATH Domain: 1lkkA00 XML data for domain: 1lkkA00

Molscript image for 1lkkA00
1lkkA00
PDB coordinates for domain 1lkkA00

PDB 1lkk, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.505 SHC Adaptor Protein
3.30.505.10 SHC Adaptor Protein Gene3D
3.30.505.10.1
3.30.505.10.1.1
3.30.505.10.1.1.1
3.30.505.10.1.1.1.1
3.30.505.10.1.1.1.1.1

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Segment boundaries for domain 1lkkA00

Chopping figure for domain 1lkkA00
DomainStart PDB ResidueStop PDB Residue
1lkkA00 122 226

Structural Neighbourhood (25 entries)

There are 25 matching structural neighberhood comparisons for CATH ID 3.30.505.10.1.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 25 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2shpA02 90.47 Tyrosine-protein phosphatase non-receptor type 11Homo sapiens 3.30.505.10 101 36 92 2.53 2.74
1nrvA00 90.28 CytoplasmInsulin receptor bindingGrowth factor receptor-bound protein 10Plasma membranePositive regulation of phosphorylation 3.30.505.10 100 25 93 1.72 1.84
1opkA02 90.17 Protein domain specific bindingNucleusManganese ion bindingPeptidyl-tyrosine phosphorylationMus musculus 3.30.505.10 102 37 88 1.75 1.98
2oq1A03 89.75 T cell receptor complexZeta-chain (TCR) associated protein kinase [EC:2.7.10.2]Natural killer cell mediated cytotoxicityPositive thymic T cell selectionTyrosine-protein kinase ZAP-70 3.30.505.10 99 31 94 1.99 2.11
1r1pB00 89.72 GRB2-related adaptor protein 2Mus musculusT cell receptor signaling pathwayProtein binding 3.30.505.10 100 34 86 1.50 1.73
3c7iA00 89.49 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 3.30.505.10 101 35 91 2.14 2.34
1i3zA00 89.41 Mus musculusSH2 domain-containing protein 1BNegative regulation of natural killer cell mediated cytotoxicityNegative regulation of peptidyl-tyrosine phosphorylationPhosphotyrosine binding 3.30.505.10 102 35 92 1.88 2.04
1d4tA00 89.04 Cell-cell signalingCytoplasmSH2 domain-containing protein 1ANatural killer cell mediated cytotoxicityHomo sapiens 3.30.505.10 104 22 94 1.90 2.02
2oq1A01 88.84 T cell receptor complexZeta-chain (TCR) associated protein kinase [EC:2.7.10.2]Natural killer cell mediated cytotoxicityPositive thymic T cell selectionTyrosine-protein kinase ZAP-70 3.30.505.10 108 27 91 1.86 2.03
1ayaA00 88.81 Hormone-mediated signaling pathwayRegulation of multicellular organism growthNerve growth factor receptor signaling pathwayTriglyceride metabolic processNegative regulation of insulin secretion 3.30.505.10 101 33 90 1.73 1.91
3eazA00 88.72 Tyrosine-protein kinase CSKEpithelial cell signaling in Helicobacter pylori infectionChemokine signaling pathwayProtein C-terminus bindingNeurotrophin signaling pathway 3.30.505.10 98 38 88 2.21 2.50
2crhA01 87.52 Vav oncogeneChemokine signaling pathwayB cell receptor signaling pathwayLeukocyte transendothelial migrationFc gamma R-mediated phagocytosis 3.30.505.10 102 31 90 2.22 2.45
1qadA00 87.09 Jak-STAT signaling pathwayAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.30.505.10 104 26 88 2.42 2.73
2dm0A01 86.34 Tyrosine-protein kinase TXKProtein phosphorylationTXK tyrosine kinase [EC:2.7.10.2]Leukocyte transendothelial migrationHomo sapiens 3.30.505.10 97 31 91 2.17 2.37
2iugA00 86.27 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 3.30.505.10 110 26 88 2.32 2.63
1ju5A00 86.04 Pathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayFc gamma R-mediated phagocytosisErbB signaling pathway 3.30.505.10 109 26 84 1.81 2.14
1milA00 85.82 Transmembrane receptor protein tyrosine kinase adaptor activitySHC-transforming protein 1Regulation of epidermal growth factor receptor activityEpidermal growth factor receptor signaling pathwayInsulin-like growth factor receptor binding 3.30.505.10 104 25 89 2.40 2.68
3bkbA01 84.94 Tyrosine-protein kinase Fes/FpsHomo sapiensCell proliferationMulticellular organismal development 3.30.505.10 93 23 82 3.16 3.81
2vifA01 83.94 CytoplasmJAK-STAT cascadeDefense responseSuppressor of cytokine signaling 6Suppressor of cytokine signaling 6 3.30.505.10 126 24 76 2.11 2.74
3buxB03 83.36 Jak-STAT signaling pathwayPathways in cancerT cell receptor signaling pathwayErbB signaling pathwayChronic myeloid leukemia 3.30.505.10 86 13 75 2.47 3.28
2kk6A00 83.10 CytoplasmFer (fps/fes related) tyrosine kinase [EC:2.7.10.2]Homo sapiensAdherens junctionTyrosine-protein kinase Fer 3.30.505.10 116 22 81 2.59 3.20
2pldA00 82.67 Phosphatidylinositol signaling systemCalcium signaling pathwayPhospholipase C, gamma [EC:3.1.4.11]Pathways in cancerNeurotrophin signaling pathway 3.30.505.10 105 20 91 3.05 3.34
1uurA04 78.91 Protein homodimerization activityNucleusSignal transducer and activator of transcription APositive regulation of transcriptionCytosol 3.30.505.10 132 15 61 2.28 3.72
1bg1A04 76.69 Positive regulation of transcription from RNA polymerase II promoterTemperature homeostasisRegulation of multicellular organism growthNucleusPlasma membrane 3.30.505.10 109 13 77 3.76 4.82
1bf5A04 75.73 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNucleolusProtein binding 3.30.505.10 112 16 71 2.89 4.05
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Displaying entries 1 to 25 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1lkkA00
LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPG
LHELVRHYTNASDGLCTRLSRPCQT
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1lkkA00
LEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPG
LHELVRHYTNASDGLCTRLSRPCQT
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 19:06

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 19:06

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 15:29

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"