CATH Domain: 1lk3A00

1lk3A00

PDB 1lk3, Chain A, Domain 0

CATH Code	Level Description	Links
1	Mainly Alpha
1.20	Up-down Bundle
1.20.1250	Growth Hormone; Chain: A;
1.20.1250.10		Gene3D
1.20.1250.10.2
1.20.1250.10.2.1
1.20.1250.10.2.1.1
1.20.1250.10.2.1.1.1
1.20.1250.10.2.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 1lk3A00

Domain	Start PDB Residue	Stop PDB Residue
1lk3A00	21	157

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (5 entries)

There are 5 matching structural neighberhood comparisons for CATH ID 1.20.1250.10.2.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
1n1fA00	85.54	Jak-STAT signaling pathwayCytokine-cytokine receptor interactionCytokine activityInterleukin 19/20/24Homo sapiens	1.20.1250.10	153	15	86	2.96	3.41
3dlqI00	84.56	Interleukin 22Jak-STAT signaling pathwayCytokine-cytokine receptor interactionHomo sapiensInterleukin-22	1.20.1250.10	131	18	88	3.68	4.17
1lqsL01	80.87	Viral interleukin-10 homologHuman herpesvirus 5 strain AD169	1.20.1250.10	100	25	65	1.96	3.00
1b5lA00	80.13	Interferon tau-1Ovis aries	1.20.1250.10	152	10	86	3.37	3.91
1wu3I00	80.01	Jak-STAT signaling pathwayInterferon, betaChagas diseaseCytokine activityNatural killer cell mediated cytotoxicity	1.20.1250.10	161	10	82	4.00	4.84

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Domain ATOM Sequence

>pdb|1lk3A00
NMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKT
LRLRLRRCHRFLPCEKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMK

BLAST against CATH

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Domain COMBS Sequence

>pdb|1lk3A00
MSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPD
IKAHVNSLGENLKTLRLRLRRCHRFLPCENGGGSGGKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN

BLAST against CATH

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Domain History Events (11)

Domain assigned by auto on 11 Mar 2009 21:11

Assigning to "1.20.1250.10" based on similarity with "1lk3B00"