CATH Domain: 1k3iA03 XML data for domain: 1k3iA03

Molscript image for 1k3iA03
1k3iA03
PDB coordinates for domain 1k3iA03

PDB 1k3i, Chain A, Domain 3

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.40 Immunoglobulin-like
2.60.40.10 Immunoglobulins Gene3D
2.60.40.10.21
2.60.40.10.21.1
2.60.40.10.21.1.1
2.60.40.10.21.1.1.1
2.60.40.10.21.1.1.1.1

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Segment boundaries for domain 1k3iA03

Chopping figure for domain 1k3iA03
DomainStart PDB ResidueStop PDB Residue
1k3iA01 -1 153
1k3iA02 154 541
1k3iA03 542 638

Structural Neighbourhood (101 entries)

There are 101 matching structural neighberhood comparisons for CATH ID 2.60.40.10.21.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 101 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
3bmvA03 84.63 Cyclomaltodextrin glucanotransferaseThermoanaerobacterium thermosulfurigenes 2.60.40.10 80 20 78 2.13 2.72
1u3zA00 84.08 Protein homodimerization activityLymph node developmentNegative regulation of interleukin-12 biosynthetic processNucleusNuclear factor NF-kappa-B p105 subunit 2.60.40.10 104 13 87 3.15 3.60
1p7hL02 83.41 Nuclear factor of activated T-cells, cytoplasmic 2Sequence-specific DNA binding transcription factor activityTranscription activator activityNucleusHomo sapiens 2.60.40.10 107 16 86 3.25 3.74
1my5A00 82.94 Pathways in cancerChemokine signaling pathwayChagas diseaseNeurotrophin signaling pathwayB cell receptor signaling pathway 2.60.40.10 107 12 81 2.89 3.55
1imhC02 82.69 Nuclear factor of activated T-cells 5Transcription from RNA polymerase II promoterSequence-specific DNA binding transcription factor activityNucleusExcretion 2.60.40.10 106 17 86 4.06 4.68
1uadC00 81.96 ExocystRattus norvegicusExocyst complex component 2 2.60.40.10 92 10 81 2.64 3.24
2uzyB03 81.60 Hepatocyte growth factor receptor activityBasal plasma membranePathways in cancerEpithelial cell signaling in Helicobacter pylori infectionProto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] 2.60.40.10 87 18 74 1.65 2.22
3iagC03 81.31 Transcription factor bindingHeart developmentRegulation of timing of cell differentiationDefense response to bacteriumChromatin binding 2.60.40.10 93 10 82 3.34 4.05
1iarB01 81.19 Jak-STAT signaling pathwayInterleukin 4 receptorIntegral to plasma membraneInterleukin-4 receptor activityHematopoietic cell lineage 2.60.40.10 96 9 88 3.32 3.74
1eerC01 80.98 Jak-STAT signaling pathwayIntegral to plasma membraneHematopoietic cell lineageErythropoietin receptor activityErythropoietin receptor 2.60.40.10 97 10 84 3.48 4.12
2brqA00 80.95 Transcription factor bindingReceptor clusteringActin filament bindingActin cytoskeleton reorganizationPositive regulation of transcription factor import into nucleus 2.60.40.10 94 7 79 3.37 4.25
1p53A01 80.93 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 98 14 79 2.95 3.71
1v05A00 80.54 Plasma membraneFilamin-CHomo sapiens 2.60.40.10 96 9 81 3.49 4.29
2nziA03 80.34 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 94 9 81 2.89 3.55
2uzyB04 80.32 Basal plasma membraneHepatocyte growth factor receptor activityEpithelial cell signaling in Helicobacter pylori infectionPathways in cancerProto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] 2.60.40.10 79 12 76 2.16 2.83
1pd6A00 80.31 Myosin-binding protein C, cardiac-typeHomo sapiensVentricular cardiac muscle tissue morphogenesisStriated muscle myosin thick filamentStructural constituent of muscle 2.60.40.10 94 9 81 3.42 4.20
2nqcA00 80.26 Plasma membraneFilamin-CHomo sapiens 2.60.40.10 97 7 80 3.34 4.15
1ix2A00 80.25 Escherichia coliCopper resistance protein C 2.60.40.1220 97 10 89 4.14 4.62
1uctA01 80.14 Immunoglobulin alpha Fc receptorIntegral to plasma membraneCD89 antigenHomo sapiensImmune response 2.60.40.10 91 9 81 3.32 4.08
1cwvA02 79.99 InvasinYersinia pseudotuberculosis 2.60.40.920 97 10 81 2.88 3.54
1f6fB01 79.70 Rattus norvegicusProlactin receptorProlactin receptor activity 2.60.40.10 97 12 84 3.92 4.64
1jmxA03 79.69 Quinohemoprotein amine dehydrogenase 60 kDa subunitPseudomonas putida 2.60.40.10 79 12 79 2.74 3.45
1cfbA01 79.54 Calcium ion bindingNeuron cell-cell adhesionNerve maturationDrosophila melanogasterEpidermal growth factor receptor signaling pathway 2.60.40.10 99 14 80 3.54 4.38
1l6zA02 79.31 Mus musculusCarcinoembryonic antigen-related cell adhesion molecule 1 2.60.40.10 96 9 79 3.57 4.50
2fcbA01 79.30 Low affinity immunoglobulin gamma Fc region receptor II-bHomo sapiensImmune responseSignal transduction 2.60.40.10 86 8 77 3.79 4.90
2gy5A04 79.18 MicrovillusCell surfaceTransmembrane receptor protein tyrosine kinase signaling pathwaySignal transductionProtein binding 2.60.40.10 99 11 86 3.62 4.17
1cwvA03 79.04 InvasinYersinia pseudotuberculosis 2.60.40.920 102 6 76 2.95 3.86
1l0qA02 79.03 Methanosarcina mazeiORF492 2.60.40.670 90 7 74 3.02 4.07
1cd9B02 78.99 Mus musculusGranulocyte colony-stimulating factor receptorNeutrophil chemotaxis 2.60.40.10 98 7 82 3.69 4.46
1qr4A01 78.93 TenascinGallus gallus 2.60.40.10 87 4 80 3.20 3.98
1fnhA03 78.88 FibronectinPeptide cross-linkingER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 89 7 80 3.09 3.84
1f2qA02 78.85 High affinity immunoglobulin epsilon receptor subunit alphaIntegral to plasma membraneHomo sapiensFc receptor, IgE, high affinity I, alpha polypeptideAsthma 2.60.40.10 90 8 78 3.82 4.88
2fnbA00 78.74 FibronectinPeptide cross-linkingER-Golgi intermediate compartmentFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 95 6 82 3.10 3.76
1qg3A01 78.70 Homo sapiensIntegrin beta-4Protein bindingIntegrin complex 2.60.40.10 91 10 81 3.87 4.75
1fnfA01 78.67 FibronectinER-Golgi intermediate compartmentPeptide cross-linkingFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 94 11 85 3.59 4.20
2ec8A04 78.64 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 100 13 83 3.66 4.41
1svbA04 78.49 Genome polyproteinTick-borne encephalitis virus (WESTERN SUBTYPE) 2.60.40.350 96 11 77 3.73 4.82
1ej6A05 78.49 Mammalian orthoreovirus 3 DearingOuter capsid protein lambda-2 2.60.40.10 95 4 78 2.60 3.32
1fnhA01 78.43 FibronectinER-Golgi intermediate compartmentPeptide cross-linkingFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 90 5 81 3.34 4.10
1ugnA01 78.42 Homo sapiensLeukocyte immunoglobulin-like receptor subfamily B member 1Integral to membraneResponse to virusProtein phosphatase 1 binding 2.60.40.10 95 8 82 3.80 4.61
1axiB02 78.39 Jak-STAT signaling pathwayCell surfaceMulticellular organismal metabolic processGrowth hormone receptor complexInsulin-like growth factor receptor signaling pathway 2.60.40.10 101 7 79 3.78 4.77
1nkrA01 78.36 Integral to plasma membraneReceptor activityHomo sapiensNatural killer cell inhibitory signaling pathwayImmune response 2.60.40.10 97 11 85 3.78 4.42
2qfpA01 78.30 Fe(3+)-Zn(2+) purple acid phosphatasePhaseolus vulgaris 2.60.40.380 97 6 82 3.51 4.26
1iarB02 78.30 Jak-STAT signaling pathwayInterleukin 4 receptorIntegral to plasma membraneReceptor signaling protein activityHematopoietic cell lineage 2.60.40.10 92 5 74 2.93 3.95
2j8hA02 78.24 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 98 13 83 3.91 4.67
1eerB02 78.20 Jak-STAT signaling pathwayIntegral to plasma membraneHematopoietic cell lineageErythropoietin receptor activityErythropoietin receptor 2.60.40.10 102 5 79 3.34 4.21
3di2B02 78.08 Interleukin-7 receptor activityRegulation of DNA recombinationInterleukin-7 receptor subunit alphaHomo sapiensCell surface receptor linked signaling pathway 2.60.40.10 103 6 78 3.83 4.87
2uzxB02 78.02 Hepatocyte growth factor receptor activityBasal plasma membraneEpithelial cell signaling in Helicobacter pylori infectionPathways in cancerProto-oncogene tyrosine-protein kinase Met [EC:2.7.10.1] 2.60.40.10 121 16 61 1.86 3.00
2hftA02 78.00 Positive regulation of endothelial cell proliferationTissue factorPositive regulation of platelet-derived growth factor receptor signaling pathwayPositive regulation of angiogenesisProtease binding 2.60.40.10 102 10 70 2.91 4.12
3cmgA04 77.99 Putative beta-galactosidaseBacteroides fragilis NCTC 9343 2.60.40.1560 87 5 77 3.43 4.44
1y6kR02 77.99 Interleukin-10 receptor activityPlasma membraneHomo sapiensInterleukin-10 receptor subunit alpha 2.60.40.10 103 10 75 3.13 4.13
1nkrA02 77.98 Receptor activityIntegral to plasma membraneHomo sapiensImmune responseNatural killer cell inhibitory signaling pathway 2.60.40.10 98 12 78 3.75 4.77
1cvrA03 77.95 Gingipain R [EC:3.4.22.37]Porphyromonas gingivalisGingipain R2 2.60.40.10 83 10 82 3.59 4.35
2e7hA01 77.82 Cell surfaceOrgan morphogenesisIntegral to plasma membraneEph receptor B4 [EC:2.7.10.1]Homo sapiens 2.60.40.10 89 7 78 3.88 4.95
1k85A00 77.80 Bacillus circulansChitinase A1 2.60.40.10 88 14 74 3.18 4.28
1bquA01 77.70 Oncostatin-M receptor complexJak-STAT signaling pathwayResponse to cytokine stimulusPositive regulation of tyrosine phosphorylation of Stat1 proteinPositive regulation of osteoblast differentiation 2.60.40.10 100 8 78 3.51 4.50
2gysA02 77.69 Jak-STAT signaling pathwayCytokine receptor common subunit betaApoptosisCytokine-cytokine receptor interactionGranulocyte macrophage colony-stimulating factor receptor complex 2.60.40.10 102 8 75 3.20 4.24
1iamA01 77.62 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 83 9 71 3.37 4.74
1n26A03 77.60 Positive regulation of chemokine productionJak-STAT signaling pathwayPositive regulation of smooth muscle cell proliferationResponse to cytokine stimulusAcute-phase response 2.60.40.10 104 2 76 3.48 4.52
1clcA01 77.56 Clostridium thermocellumEndoglucanase D 2.60.40.10 102 10 78 3.17 4.04
1qfhA01 77.44 ThermotaxisPhagocytic cupMembrane fractionPhototaxisProtein homodimerization activity 2.60.40.10 111 9 74 3.14 4.20
1bquA02 77.41 Jak-STAT signaling pathwayOncostatin-M receptor complexResponse to cytokine stimulusPositive regulation of tyrosine phosphorylation of Stat1 proteinPositive regulation of osteoblast differentiation 2.60.40.10 108 5 75 3.29 4.39
1owwA00 77.37 FibronectinER-Golgi intermediate compartmentPeptide cross-linkingFibrinogen complexSubstrate adhesion-dependent cell spreading 2.60.40.10 93 11 83 3.83 4.59
2gysB04 77.17 Jak-STAT signaling pathwayCytokine receptor common subunit betaApoptosisCytokine-cytokine receptor interactionGranulocyte macrophage colony-stimulating factor receptor complex 2.60.40.10 99 8 76 3.73 4.86
2rb8A00 77.14 TenascinCell adhesionSyndecan bindingECM-receptor interactionTenascin 2.60.40.10 93 9 84 3.92 4.64
1nepA00 77.07 LysosomeBos taurusNiemann-Pick C2 proteinEpididymal secretory protein E1 2.60.40.770 130 10 64 2.79 4.32
1g0dA01 77.07 Protein-glutamine gamma-glutamyltransferase 2Pagrus major 2.60.40.10 137 12 63 2.32 3.65
1fyhB02 76.83 Jak-STAT signaling pathwayInterferon gamma receptor 1Integral to plasma membraneChagas diseaseInterferon-gamma receptor activity 2.60.40.10 103 9 74 3.29 4.40
1i1rA01 76.79 Jak-STAT signaling pathwayOncostatin-M receptor complexResponse to cytokine stimulusPositive regulation of osteoblast differentiationPositive regulation of tyrosine phosphorylation of Stat1 protein 2.60.40.10 100 8 78 3.70 4.74
1nctA00 76.77 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 98 14 84 3.69 4.36
1t2jA00 76.74 Homo sapiensSingle chain Fv 2.60.40.10 116 13 71 3.37 4.71
1tvdA00 76.72 Homo sapiensHDV103S1 2.60.40.10 116 7 70 3.50 4.95
1witA00 76.65 Caenorhabditis elegansProtein ZK617.1b, partially confirmed by transcript evidenceLocomotionReproduction 2.60.40.10 93 17 84 3.97 4.70
1pbyA03 76.62 Paracoccus denitrificansQuinohemoprotein amine dehydrogenase 60 kDa subunit 2.60.40.10 76 11 74 3.15 4.24
1yc7A00 76.59 2.60.40.10 116 13 71 3.45 4.82
1t0pB00 76.55 Integral to plasma membraneIntercellular adhesion molecule 3Homo sapiensIntercellular adhesion molecule 3Cell adhesion molecules (CAMs) 2.60.40.10 86 9 71 3.50 4.92
2ialA01 76.54 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 108 8 75 3.67 4.83
1axiB01 76.43 Jak-STAT signaling pathwayMulticellular organismal metabolic processCell surfaceGrowth hormone receptor complexInsulin-like growth factor receptor signaling pathway 2.60.40.10 86 11 80 3.79 4.71
1waaC00 76.32 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 93 7 80 3.59 4.46
3hn3A02 76.31 Beta-glucuronidaseGlycosaminoglycan degradationGlycosaminoglycan catabolic processMetabolic pathwaysStarch and sucrose metabolism 2.60.40.320 103 7 74 3.11 4.16
2gysA03 76.29 Jak-STAT signaling pathwayGranulocyte macrophage colony-stimulating factor receptor complexCytokine receptor common subunit betaCytokine receptor common subunit betaApoptosis 2.60.40.10 86 8 77 3.80 4.91
2cumA00 76.25 Collagen metabolic processElastic fiber assemblyIntracellularHomo sapiensTenascin-X 2.60.40.10 105 10 78 3.75 4.80
3b9eA01 76.18 Vibrio harveyiChitinase A 2.60.40.10 110 6 73 3.12 4.24
2rikA01 76.14 TitinOryctolagus cuniculus 2.60.40.10 96 12 81 3.63 4.46
1dr9A02 75.95 Type I diabetes mellitusIntestinal immune network for IgA productionAutoimmune thyroid diseaseAllograft rejectionT-lymphocyte activation antigen CD80 2.60.40.10 95 7 80 3.52 4.38
1q0xL02 75.84 Mus musculusIg lambda-1 chain V regionProtein binding 2.60.40.10 100 7 81 3.76 4.64
1ehxA00 75.47 Scaffolding proteinClostridium cellulolyticum 2.60.40.10 94 12 79 3.93 4.95
2ec8A05 75.38 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 81 8 76 3.43 4.50
3b43A02 75.36 TitinOryctolagus cuniculus 2.60.40.10 97 9 82 3.95 4.79
1hxmA01 75.25 2.60.40.10 121 7 69 3.42 4.93
1jz7A02 75.23 Galactose metabolismSphingolipid metabolismOther glycan degradationMetabolic pathwaysLactose catabolic process 2.60.40.320 114 4 78 3.90 5.00
1eh9A03 75.06 Sulfolobus solfataricusMalto-oligosyltrehalose trehalohydrolase 2.60.40.10 87 5 68 2.90 4.26
2ec8A02 75.00 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaProtein binding 2.60.40.10 87 5 80 3.45 4.29
2hftA01 74.96 Positive regulation of endothelial cell proliferationTissue factorPositive regulation of platelet-derived growth factor receptor signaling pathwayPositive regulation of angiogenesisProtease binding 2.60.40.10 103 1 78 3.83 4.87
1im3D00 74.82 Unique short US2 glycoproteinHuman herpesvirus 5 strain AD169 2.60.40.1200 95 9 85 3.62 4.23
3bgaA04 74.79 Galactose metabolismBacteroides thetaiotaomicronBeta-galactosidaseSphingolipid metabolismBeta-galactosidase [EC:3.2.1.23] 2.60.40.320 105 7 77 3.78 4.90
2g5rA00 74.78 Sialic acid-binding Ig-like lectin 7Sialic acid binding Ig-like lectin 7Receptor activityIntegral to plasma membraneHomo sapiens 2.60.40.10 113 10 74 3.64 4.90
2c5dC01 74.71 Integral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiensTyrosine-protein kinase receptor UFOSignal transduction 2.60.40.10 104 10 79 3.28 4.11
1mfaH01 74.68 2.60.40.10 97 6 70 3.22 4.59
3h9yA02 74.53 Homo sapiensIg epsilon chain C region 2.60.40.10 108 5 75 3.73 4.91
1j0hA01 72.52 NeopullulanaseGeobacillus stearothermophilus 2.60.40.10 125 6 72 3.51 4.82
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Displaying entries 1 to 101 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1k3iA03
TRPKITRTSTQSVKVGGRITISTDSSISKASLIRYGTATHTVNTDQRRIPLTLTNNGGNSYSFQVPSDSGVALPGYWMLF
VMNSAGVPSVASTIRVT
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1k3iA03
TRPKITRTSTQSVKVGGRITISTDSSISKASLIRYGTATHTVNTDQRRIPLTLTNNGGNSYSFQVPSDSGVALPGYWMLF
VMNSAGVPSVASTIRVT
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:38

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:38

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 17:01

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"