CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P03474
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P03474
NRAM_INBLE
Influenza B virus (B/Lee/1940)
Neuraminidase

PDB Structure

PDB 1INF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-based inhibitors of influenza virus sialidase. A benzoic acid lead with novel interaction.
Singh, S., Jedrzejas, M.J., Air, G.M., Luo, M., Laver, W.G., Brouillette, W.J.
J.Med.Chem.