CATH Classification

Domain Context

CATH Clusters

Superfamily Carbonic anhydrase
Functional Family Carbonic anhydrase

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P61517
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P61517
CAN_ECOLI
Escherichia coli K-12
Carbonic anhydrase 2

PDB Structure

PDB 1I6O
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of E. coli beta-carbonic anhydrase, an enzyme with an unusual pH-dependent activity.
Cronk, J.D., Endrizzi, J.A., Cronk, M.R., O'neill, J.W., Zhang, K.Y.
Protein Sci.