CATH Domain: 1hw1A01

1hw1A01

PDB 1hw1, Chain A, Domain 1

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.10	Arc Repressor Mutant, subunit A
1.10.10.10	"winged helix" repressor DNA binding domain	Gene3D
1.10.10.10.9
1.10.10.10.9.1
1.10.10.10.9.1.1
1.10.10.10.9.1.1.1
1.10.10.10.9.1.1.1.1

Structure
Sequence
History

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Segment boundaries for domain 1hw1A01

Domain	Start PDB Residue	Stop PDB Residue
1hw1A01	5	79
1hw1A02	80	230

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Neighbourhood (61 entries)

There are 61 matching structural neighberhood comparisons for CATH ID 1.10.10.10.9.1.1.1.1 (SIMAX score < 5)

Match	SSAP score	Match Keywords	Match Superfamily	Length	Sequence Id	Overlap	RMSD	SIMAX
3by6C01	89.56	GntR family transcriptional regulatorOenococcus oeni PSU-1Transcriptional regulator, GntR family	1.10.10.10	77	13	89	1.92	2.14
3edpA01	89.33	Listeria innocuaLin2111 protein	1.10.10.10	75	21	96	3.66	3.81
3bwgB01	88.98	GntR family transcriptional regulator, transcriptional regulator of bglABacillus subtilisUncharacterized HTH-type transcriptional regulator yydK	1.10.10.10	68	19	90	1.90	2.10
2hs5A01	88.55	Rhodococcus jostii RHA1Probable transcriptional regulator, GntR family protein	1.10.10.10	67	23	89	1.83	2.05
2g7uA01	86.61	Rhodococcus opacusPutative regulator of catechol degradative operon	1.10.10.10	74	16	92	3.87	4.21
1sfuA00	86.02	Yaba-like disease virus34L protein	1.10.10.10	70	8	90	2.83	3.12
1qbjC00	85.41	CytoplasmNucleolusHomo sapiensDouble-stranded RNA-specific adenosine deaminaseBase conversion or substitution editing	1.10.10.10	66	21	85	2.31	2.71
1lvaA03	85.37	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	62	14	82	2.78	3.36
1z05A01	85.17	Vibrio choleraeTranscriptional regulator, ROK family	1.10.10.10	72	8	82	2.69	3.25
1ft9A02	84.85	Rhodospirillum rubrumCooA protein	1.10.10.10	79	16	86	3.22	3.74
1jhfA02	84.73	Repressor LexA [EC:3.4.21.88]TranscriptionDNA bindingLexA repressorTranscription repressor activity	1.10.10.10	69	17	88	4.28	4.86
1hw5A02	84.51	TranscriptionTranscription activator activityTranscription repressor activityCRP/FNR family transcriptional regulator, cyclic AMP receptor proteinCatabolite gene activator	1.10.10.10	68	17	80	2.86	3.58
2p8tA01	84.40	Pyrococcus horikoshiiPutative uncharacterized protein PH0730	1.10.10.10	75	9	78	2.90	3.69
2dtrA01	84.37	DtxR family transcriptional regulator, Mn-dependent transcriptional regulatorDiphtheria toxin repressorCorynebacterium diphtheriae	1.10.10.10	71	14	92	4.51	4.90
3c7jA01	84.35	Pseudomonas syringae pv. syringaeRegulatory protein GntR	1.10.10.10	87	28	77	2.65	3.44
1on2A01	84.01	Bacillus subtilisTranscriptional regulator mntR	1.10.10.10	72	15	92	4.28	4.65
1in4A02	83.94	Holliday junction DNA helicase RuvBThermotoga maritimaHomologous recombinationHolliday junction ATP-dependent DNA helicase ruvB	1.10.10.10	73	15	90	4.18	4.61
1w1wE00	83.79	Nuclear mitotic cohesin complexProtein acetylationChromatin bindingCohesin complex subunit SCC1Establishment of mitotic sister chromatid cohesion	1.10.10.580	70	5	85	3.24	3.80
1lvaA01	83.79	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	59	16	74	2.73	3.66
2ia2C01	83.77	Rhodococcus sp. DK17PcaR	1.10.10.10	60	15	80	2.52	3.15
2heoA00	83.76	Mus musculusLeft-handed Z-DNA bindingZ-DNA-binding protein 1	1.10.10.10	59	20	78	2.71	3.44
2ia2D01	83.69	Rhodococcus sp. DK17PcaR	1.10.10.10	57	14	76	2.77	3.64
3bz6A02	83.65	Hypothetical proteinPseudomonas syringae pv. tomatoUPF0502 protein PSPTO_2686	1.10.10.10	76	10	84	4.04	4.80
1ldjA06	83.61	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	1.10.10.10	68	13	74	2.64	3.54
2o0yB01	83.54	Rhodococcus jostii RHA1Transcriptional regulator	1.10.10.10	64	15	85	3.25	3.81
1mkmB01	83.49	Thermotoga maritimaTranscriptional regulator, IclR family	1.10.10.10	76	12	90	3.33	3.67
2jt1A00	83.40	PefI proteinSalmonella enterica subsp. enterica serovar Typhimurium	1.10.10.10	71	12	88	3.94	4.48
1lvaA02	83.31	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	69	10	81	3.11	3.82
3cuqB03	83.27	Homo sapiensVacuolar protein-sorting-associated protein 36ESCRT-II complex subunit VPS36Endocytosis	1.10.10.10	69	14	88	3.36	3.82
2hr3D02	83.24	Probable transcriptional regulatorPseudomonas aeruginosa	1.10.10.10	61	16	78	3.34	4.25
1lddA00	83.14	Mitotic sister chromatid segregationProtein ubiquitinationCyclin catabolic processMeiosis - yeastAnaphase-promoting complex subunit 2	1.10.10.10	74	9	84	2.71	3.23
1j5yA01	82.98	Thermotoga maritimaTranscriptional regulator, biotin repressor family	1.10.10.10	64	10	85	3.02	3.54
2ns0A00	82.72	Rhodococcus jostii RHA1Putative uncharacterized protein	1.10.10.10	82	12	80	3.01	3.74
2o0yC01	82.64	Rhodococcus jostii RHA1Transcriptional regulator	1.10.10.10	73	12	81	3.02	3.71
1cf7A00	82.64	Protein domain specific bindingTranscription factor bindingE2F transcription factor 4/5Transcription factor E2F4TGF-beta signaling pathway	1.10.10.10	67	4	85	3.03	3.55
1cf7B00	82.59	Protein domain specific bindingTranscription factor Dp-2Transcription cofactor activityHomo sapiens	1.10.10.10	82	10	75	2.43	3.21
3ctaA01	82.56	Riboflavin metabolismRiboflavin kinaseRiboflavin kinase, archaea type [EC:2.7.1.161]Thermoplasma acidophilum	1.10.10.10	84	9	82	3.87	4.71
2gauA02	82.50	Transcriptional regulator, Crp/Fnr familyPorphyromonas gingivalis	1.10.10.10	81	13	83	3.88	4.62
1lvaA04	82.16	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1.10.10.10	60	16	80	3.07	3.84
1biaA01	81.76	Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity	1.10.10.10	64	18	84	4.10	4.88
2fnaA03	81.69	Sulfolobus solfataricusPutative uncharacterized protein	1.10.10.10	72	8	82	3.62	4.38
1hstA00	81.57	Histone H1/5Gallus gallusHistone H5	1.10.10.10	74	12	84	3.61	4.30
2hoeA01	81.13	Thermotoga maritimaTranscriptional regulator, XylR-related	1.10.10.10	57	22	69	2.41	3.48
1s3jA02	80.73	Bacillus subtilisUncharacterized HTH-type transcriptional regulator yusO	1.10.10.10	62	12	77	3.53	4.56
3cuqA02	80.56	ESCRT-II complex subunit VPS22Transcription factor bindingRegulation of transcription from RNA polymerase II promoterHomo sapiensVacuolar-sorting protein SNF8	1.10.10.10	81	17	85	3.94	4.63
1t6sB02	80.43	Chlorobaculum tepidumSegregation and condensation protein BSegregation and condensation protein B	1.10.10.10	77	8	85	3.98	4.64
3dfgA01	79.86	Xanthomonas campestris pv. campestrisRegulatory proteinRegulatory protein recX	1.10.10.10	48	12	62	2.27	3.62
1q1hA00	79.43	Sulfolobus solfataricusTranscription initiation factor TFIIE alpha subunitTranscription factor EBasal transcription factors	1.10.10.10	85	9	75	3.51	4.66
1u5tB01	78.86	Protein targeting to vacuoleVacuolar protein-sorting-associated protein 36Protein retention in Golgi apparatusUbiquitin bindingEndocytosis	1.10.10.10	85	9	75	3.38	4.49
1xb4B02	78.73	Protein targeting to vacuoleESCRT-II complex subunit VPS25Saccharomyces cerevisiaeESCRT II complexVacuolar protein-sorting-associated protein 25	1.10.10.10	75	14	84	3.79	4.51
1bbyA00	78.61	Basal transcription factorsGeneral transcription factor IIF subunit 2General RNA polymerase II transcription factor activityHomo sapiensTranscription initiation factor TFIIF beta subunit	1.10.10.10	69	5	85	3.59	4.21
3cuqD00	78.58	ESCRT-II complex subunit VPS25Homo sapiensVacuolar protein-sorting-associated protein 25Endocytosis	1.10.10.570	97	10	67	3.27	4.88
1u5tB02	78.35	Protein targeting to vacuoleVacuolar protein-sorting-associated protein 36Protein retention in Golgi apparatusUbiquitin bindingEndocytosis	1.10.10.10	69	17	82	3.45	4.17
3dfgA02	78.22	Xanthomonas campestris pv. campestrisRegulatory proteinRegulatory protein recX	1.10.10.10	46	8	61	2.75	4.48
1oyiA00	78.12	Vaccinia virusDouble-stranded RNA-binding protein	1.10.10.10	62	12	82	3.64	4.40
1d8jA00	77.53	Basal transcription factorsTranscription initiation factor IIE subunit betaTranscription initiation factor TFIIE beta subunitHomo sapiensProtein binding	1.10.10.10	81	5	82	4.04	4.88
3bqzA01	76.30	HTH-type transcriptional regulator qacRStaphylococcus aureus subsp. aureus Mu50	1.10.10.60	49	10	65	3.12	4.78
1ldkB03	76.11	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	1.10.10.10	83	5	74	3.72	4.98
1s6lA01	76.06	Alkylmercury lyaseEscherichia coli	1.10.10.10	52	7	69	3.30	4.76
2gtgA00	75.58	Proactivator polypeptideLipid transportGlycosphingolipid metabolic processEnzyme activator activityIntegral to membrane	1.10.225.10	78	6	74	3.69	4.96
3c18A03	74.78	Exiguobacterium sibiricum 255-15Putative uncharacterized protein	1.10.10.10	54	7	60	2.96	4.93

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Domain ATOM Sequence

>pdb|1hw1A01
AQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSG

BLAST against CATH

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Domain COMBS Sequence

>pdb|1hw1A01
MVIKAQSPAGFAEEYIIESIWNNRFPPGTILPAERELSELIGVTRTTLREVLQRLARDGWLTIQHGKPTKVNNFWETSG

BLAST against CATH

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Domain History Events (206)

Domain assigned by lewis on 09 Jan 2007 13:16

Assigning domain 1hw1A01 to 1.10.10.10 (as agreed with the CATH update team) after the chain has been rechopped. The reason is that the domain is very similar to the old domain 1hw1A01 (from the previous chopping at "Sun Mar 5 16:48:16 2006") which was in 1.10.10.10 at the time the chain was unchopped.