CATH Domain: 1h4rA01 XML data for domain: 1h4rA01

Molscript image for 1h4rA01
1h4rA01
PDB coordinates for domain 1h4rA01

PDB 1h4r, Chain A, Domain 1

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.10 Roll
3.10.20 Ubiquitin-like (UB roll)
3.10.20.90 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 Gene3D
3.10.20.90.6
3.10.20.90.6.1
3.10.20.90.6.1.1
3.10.20.90.6.1.1.1
3.10.20.90.6.1.1.1.1

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Segment boundaries for domain 1h4rA01

Chopping figure for domain 1h4rA01
DomainStart PDB ResidueStop PDB Residue
1h4rA01 21 98
1h4rA02 99 215
1h4rA03 217 307

Structural Neighbourhood (49 entries)

There are 49 matching structural neighberhood comparisons for CATH ID 3.10.20.90.6.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 49 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2he7A01 91.34 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 3.10.20.90 80 28 95 1.30 1.37
1z2mA02 89.25 RIG-I-like receptor signaling pathwayInterferon-induced 17 kDa proteinISG15-protein conjugationHomo sapiensUbiquitin cross-reactive protein 3.10.20.90 77 9 91 1.59 1.75
1yqbA01 88.36 Ubiquilin-3Homo sapiensUbiquilin 3.10.20.90 71 14 91 1.61 1.77
1wh3A01 88.01 CytoplasmDNA binding59 kDa 2'-5'-oligoadenylate synthase-like proteinThyroid hormone receptor bindingNucleolus 3.10.20.90 71 11 89 1.72 1.92
1wywB00 87.95 Nuclear poreNegative regulation of transcriptionSmall ubiquitin-related modifier 1Protein bindingProtein sumoylation 3.10.20.90 79 11 89 1.66 1.85
2fazA00 86.28 E3 ubiquitin-protein ligase UHRF1RNA polymerase II transcription factor activityProtein bindingCell proliferationSequence-specific DNA binding transcription factor activity 3.10.20.90 77 12 91 1.86 2.04
1p1aA00 86.18 Nucleotide excision repairUV excision repair protein RAD23 homolog BSingle-stranded DNA bindingHomo sapiensUV excision repair protein RAD23 3.10.20.90 85 12 84 2.05 2.42
1lfdA00 85.95 Rattus norvegicusRal guanine nucleotide dissociation stimulatorSmall GTPase mediated signal transduction 3.10.20.90 87 11 88 2.72 3.07
1m94A00 85.94 Ubiquitin-like protein 5Protein modification processProtein bindingNuclear mRNA splicing, via spliceosomeMating projection 3.10.20.90 73 13 91 2.25 2.47
1y8rC00 85.77 Nuclear poreNegative regulation of transcriptionSmall ubiquitin-related modifier 1Protein sumoylationProtein binding 3.10.20.90 84 11 84 1.70 2.01
1oeyA00 85.73 Protein C-terminus bindingNeutrophil cytosol factor 2Leukocyte transendothelial migrationCellular defense responseSuperoxide anion generation 3.10.20.90 78 16 92 2.30 2.49
2kd0A01 85.70 LRR repeats and ubiquitin-like domain-containing protein At2g30105Arabidopsis thaliana 3.10.20.90 71 12 91 1.79 1.97
1z2mA01 85.62 RIG-I-like receptor signaling pathwayInterferon-induced 17 kDa proteinISG15-protein conjugationHomo sapiensUbiquitin cross-reactive protein 3.10.20.90 75 8 91 2.11 2.32
1wx9A00 85.24 Large proline-rich protein BAT3Homo sapiensProtein binding 3.10.20.90 86 16 81 1.93 2.37
3ge3C00 84.94 Pseudomonas mendocinaToluene-4-monooxygenase system protein B 3.10.20.270 83 5 89 2.72 3.05
2c60A01 84.69 Neurotrophin signaling pathwayMitogen-activated protein kinase kinase kinase 3MAPKKK cascadeProtein bindingPositive regulation of I-kappaB kinase/NF-kappaB cascade 3.10.20.240 77 11 93 2.71 2.90
1h8cA00 84.25 Cytoplasmic sequestering of NF-kappaBHeat shock protein bindingFAS-associated factor 1CytosolPositive regulation of protein complex assembly 3.10.20.90 82 17 87 2.55 2.90
1wxmA01 84.24 Bladder cancerPathways in cancerNon-small cell lung cancerAcute myeloid leukemiaProtein binding 3.10.20.90 71 12 89 2.34 2.61
1t0yA00 84.06 Caenorhabditis elegansTubulin-specific chaperone B 3.10.20.90 90 17 83 2.79 3.35
1wmhA00 83.89 Tight junctionInsulin signaling pathwayEndocytosisVesicle-mediated transportProtein binding 3.10.20.240 83 8 93 2.77 2.95
2nptB01 83.88 Mitogen-activated protein kinase kinase kinase 2Gap junctionMitogen-activated protein kinase kinase kinase 2 [EC:2.7.11.25]GnRH signaling pathwayMAPK signaling pathway 3.10.20.240 81 12 91 2.80 3.06
1oqyA01 83.81 Nucleotide excision repairNucleotide-excision repairUV excision repair protein RAD23 homolog ASingle-stranded DNA bindingHomo sapiens 3.10.20.90 79 15 93 2.96 3.16
2rd0A01 83.79 Jak-STAT signaling pathwayAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.10.20.90 100 5 75 2.08 2.77
3kh0A00 83.41 Ral guanine nucleotide dissociation stimulatorSmall GTPase regulator activityHomo sapiens 3.10.20.90 102 10 75 2.76 3.66
1k8rB00 83.13 Plasma membraneInduction of conjugation upon nitrogen starvationProtein bindingSchizosaccharomyces pombeProtein kinase byr2 3.10.20.90 82 3 76 2.64 3.44
1wgdA00 83.11 Endoplasmic reticulum membraneHomo sapiensHomocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 proteinProtein binding 3.10.20.90 93 15 79 2.36 2.97
1wmhB00 82.74 Partitioning defective 6 homolog alphaTranscription factor bindingViral reproductionHomo sapiens 3.10.20.240 82 12 93 2.76 2.94
1v5tA00 82.71 Mus musculusUbiquitin-like domain-containing CTD phosphatase 1Protein phosphatase [EC:3.1.3.16] 3.10.20.90 90 8 82 2.56 3.11
1uh6A00 82.60 Mus musculusUbiquitin-like protein 5Ubiquitin-like protein 5 3.10.20.90 100 12 71 2.05 2.89
1v5oA00 82.53 Mus musculusDNA damage-inducible protein 1Protein DDI1 homolog 1 3.10.20.90 102 6 69 2.09 3.00
1c1yB00 82.23 RAF proto-oncogene serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayProtein binding 3.10.20.90 77 10 92 2.66 2.88
2fnjB00 82.14 Renal cell carcinomaPathways in cancerUbiquitin mediated proteolysisMus musculusTranscription elongation factor B polypeptide 2 3.10.20.90 98 11 74 2.34 3.14
2r2oA00 81.86 Semaphorin receptor bindingPlexin BSemaphorin receptor activityHomo sapiensPlexin-B1 3.10.20.90 98 6 76 2.51 3.28
1j8cA00 81.74 CytoplasmPlasma membraneHomo sapiensUbiquilinUbiquilin-2 3.10.20.90 103 14 68 2.16 3.13
2nptC01 81.44 Homo sapiensProtein bindingDual specificity mitogen-activated protein kinase kinase 5 3.10.20.240 88 14 84 2.77 3.29
1ip9A00 81.16 MAPK signaling pathway - yeastMating projection tipIdentical protein bindingEstablishment of cell polarityPhosphatidylinositol-3-phosphate binding 3.10.20.240 85 12 84 3.39 4.00
1v2yA00 81.13 U11/U12 small nuclear ribonucleoprotein 25 kDa proteinMus musculus 3.10.20.90 105 19 68 2.21 3.22
1v86A00 80.86 Mus musculusPutative uncharacterized protein 3.10.20.90 95 11 73 1.98 2.69
1se9A00 80.80 Membrane-anchored ubiquitin-fold protein 1Arabidopsis thaliana 3.10.20.90 101 12 73 2.63 3.59
1oeyL00 79.28 Protein dimerization activityLeukocyte transendothelial migrationNeutrophil cytosolic factor 4CytosolNADPH oxidase complex 3.10.20.240 96 19 78 3.00 3.84
2kfjA00 78.49 Cell division control protein 24MAPK signaling pathway - yeastMating projection tipInvasive growth in response to glucose limitationCell division control protein 24 3.10.20.240 86 10 86 3.36 3.90
3d32B00 77.79 Regulation of autophagySynaptic transmissionPlasma membraneProtein targetingGamma-aminobutyric acid receptor-associated protein 3.10.20.90 116 5 63 2.57 4.03
2zjdA00 77.61 Microtubule-associated protein 1 light chainHomo sapiensMicrotubule-associated proteins 1A/1B light chain 3BProtein binding 3.10.20.90 121 11 61 2.58 4.16
1wxsA00 76.90 CytoplasmUbiquitin-fold modifier 1NucleusProtein ufmylationHomo sapiens 3.10.20.90 88 2 76 2.89 3.80
1y8qD03 76.61 SUMO-activating enzyme subunit 2Ubiquitin-like 1-activating enzyme E1 B [EC:6.3.2.19]Enzyme activator activityHomo sapiensUbiquitin mediated proteolysis 3.10.290.20 105 11 60 2.47 4.05
2qdzA02 74.76 Filamentous hemagglutinin transporter protein fhaCHemolysin activation/secretion proteinBordetella pertussis 3.10.20.310 82 5 75 3.67 4.85
1s3sH00 74.47 Rattus norvegicusGolgi organizationCellular membrane fusionNSFL1 cofactor p47Protein binding 3.10.20.90 107 7 67 3.33 4.95
1bmlC03 74.13 Streptokinase CStreptococcus dysgalactiae subsp. equisimilisProtein binding 3.10.20.150 83 3 71 3.51 4.94
1e8yA01 73.01 Jak-STAT signaling pathwayPhosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]Aldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNon-small cell lung cancer 3.10.20.90 165 6 44 2.20 4.97
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Displaying entries 1 to 49 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1h4rA01
TFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLA
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1h4rA01
TFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLA
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:50

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:50

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 16:43

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"