CATH Domain: 1gafH02 XML data for domain: 1gafH02

Molscript image for 1gafH02
1gafH02
PDB coordinates for domain 1gafH02

PDB 1gaf, Chain H, Domain 2

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.60 Sandwich
2.60.40 Immunoglobulin-like
2.60.40.10 Immunoglobulins Gene3D
2.60.40.10.19
2.60.40.10.19.1
2.60.40.10.19.1.1
2.60.40.10.19.1.1.1
2.60.40.10.19.1.1.1.22

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Segment boundaries for domain 1gafH02

Chopping figure for domain 1gafH02
DomainStart PDB ResidueStop PDB Residue
1gafH01 1 114
1gafH02 115 214

Structural Neighbourhood (115 entries)

There are 115 matching structural neighberhood comparisons for CATH ID 2.60.40.10.19.1.1.1.22 (SIMAX score < 5)

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Displaying entries 1 to 115 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1seqH02 93.94 Rattus norvegicusIghg protein 2.60.40.10 98 64 97 1.20 1.24
1q72H02 92.19 2.60.40.10 89 67 88 1.05 1.19
1mcpH02 88.89 Mus musculusIg heavy chain V region M603 2.60.40.10 99 28 95 2.45 2.58
1q0xL02 88.76 Mus musculusIg lambda-1 chain V regionProtein binding 2.60.40.10 100 29 96 1.96 2.04
1dn0D02 88.28 2.60.40.10 94 31 87 1.85 2.12
1l6xA02 88.07 Ig gamma-1 chain C regionHomo sapiensProtein bindingAntigen binding 2.60.40.10 106 27 93 1.97 2.11
1fv1B02 87.69 HLA class II histocompatibility antigen, DR beta 5 chainMajor histocompatibility complex, class IIType I diabetes mellitusAutoimmune thyroid diseaseIntestinal immune network for IgA production 2.60.40.10 98 15 95 2.64 2.78
3dbxA02 87.59 CD1-2 antigenGallus gallus 2.60.40.10 99 19 93 2.47 2.65
1uvqA02 87.43 2.60.40.10 99 28 96 2.12 2.21
1ow0A02 86.66 Homo sapiensProtein bindingIg alpha-1 chain C region 2.60.40.10 109 21 91 2.01 2.19
1l6xA01 86.28 Ig gamma-1 chain C regionHomo sapiensProtein bindingAntigen binding 2.60.40.10 100 25 92 2.08 2.26
1o0vA01 86.07 Homo sapiensIg epsilon chain C region 2.60.40.10 102 19 94 2.44 2.59
3h9yB01 86.00 Homo sapiensIg epsilon chain C region 2.60.40.10 101 18 94 2.49 2.65
1hxmB02 85.46 Homo sapiensT-cell receptor gamma-2 chain C region 2.60.40.10 105 20 92 2.37 2.57
3fruA02 85.25 IgG receptor FcRn large subunit p51Beta-2-microglobulin bindingRattus norvegicusHumoral immune responseIgG receptor activity 2.60.40.10 92 18 90 2.93 3.25
3g08A02 85.05 Antigen-presenting glycoprotein CD1d1Endogenous lipid antigen bindingPositive thymic T cell selectionAntigen processing and presentation, exogenous lipid antigen via MHC class IbProtein binding 2.60.40.10 88 15 86 1.99 2.31
1u58A02 85.01 Murine cytomegalovirus (strain K181)Immunoevasin 2.60.40.10 100 18 92 2.56 2.78
1je6A02 84.84 Response to heatMHC class I polypeptide-related sequence BGamma-delta T cell activationImmune response-activating cell surface receptor signaling pathwayResponse to retinoic acid 2.60.40.10 89 14 85 2.41 2.83
1t7vA02 84.72 Cell adhesionHomo sapiensZinc-alpha-2-glycoprotein 2.60.40.10 90 26 87 2.65 3.04
3h9yA02 84.66 Homo sapiensIg epsilon chain C region 2.60.40.10 108 18 92 2.35 2.54
2bc4D02 84.34 Major histocompatibility complex, class IIType I diabetes mellitusAutoimmune thyroid diseaseIntestinal immune network for IgA productionAllograft rejection 2.60.40.10 107 20 89 3.50 3.90
2fbjH02 84.33 Mus musculusIg heavy chain V region J539 2.60.40.10 73 31 71 2.53 3.55
2bnuB02 84.25 T-cell receptor beta-1 chain C regionHomo sapiensProtein binding 2.60.40.10 126 23 79 2.16 2.72
1ow0A01 83.86 Homo sapiensProtein bindingIg alpha-1 chain C region 2.60.40.10 100 20 96 2.82 2.94
2bc4A02 83.35 HLA class II histocompatibility antigen, DM alpha chainHomo sapiensProtein binding 2.60.40.10 109 16 88 2.50 2.81
1hxmA02 82.14 2.60.40.10 85 22 84 3.41 4.05
2ec8A03 82.08 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Acute myeloid leukemiaProtein binding 2.60.40.10 104 11 92 3.47 3.76
2rikA01 81.57 TitinOryctolagus cuniculus 2.60.40.10 96 12 85 3.33 3.91
1vcaA01 81.41 Vascular cell adhesion protein 1MicrovillusPositive regulation of T cell proliferationHeterophilic cell-cell adhesionFilopodium 2.60.40.10 89 17 79 3.13 3.95
2bk8A00 81.23 Structural constituent of muscleCalcium ion bindingTelethonin bindingSarcomere organizationActin filament binding 2.60.40.10 97 14 83 3.00 3.61
2a38B01 81.06 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 99 12 85 2.92 3.43
1fhgA00 81.04 TelokinMeleagris gallopavo 2.60.40.10 102 10 86 3.22 3.73
1mh5B02 80.78 2.60.40.10 52 75 51 0.85 1.65
2rikA03 80.66 TitinOryctolagus cuniculus 2.60.40.10 92 14 80 2.88 3.59
1iamA02 80.46 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 102 13 87 3.22 3.69
2j8hA01 80.38 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 97 11 83 2.90 3.49
1zxqA02 80.33 Intercellular adhesion molecule 2Integral to plasma membraneIntercellular adhesion molecule 2Natural killer cell mediated cytotoxicityHomo sapiens 2.60.40.10 107 12 86 3.31 3.81
1dr9A02 80.06 Type I diabetes mellitusIntestinal immune network for IgA productionAutoimmune thyroid diseaseAllograft rejectionT-lymphocyte activation antigen CD80 2.60.40.10 95 15 91 4.43 4.86
3b43A02 80.03 TitinOryctolagus cuniculus 2.60.40.10 97 14 84 3.08 3.66
2rikA02 79.92 TitinOryctolagus cuniculus 2.60.40.10 95 12 82 3.37 4.10
2j8hA02 79.77 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 98 7 80 3.23 4.03
2gy5A01 79.43 Cell surfaceMicrovillusIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase signaling pathwaySignal transduction 2.60.40.10 99 8 88 3.83 4.35
1witA00 79.41 Caenorhabditis elegansProtein ZK617.1b, partially confirmed by transcript evidenceLocomotionReproduction 2.60.40.10 93 13 81 3.37 4.15
1g1cA00 79.35 Structural constituent of muscleCalcium ion bindingTelethonin bindingSarcomere organizationActin filament binding 2.60.40.10 98 6 85 3.24 3.81
1gsmA02 79.34 Membrane fractionMucosal vascular addressin cell adhesion molecule 1Intestinal immune network for IgA productionCell adhesionHomo sapiens 2.60.40.10 116 7 81 3.57 4.36
1itbB03 79.28 Platelet-derived growth factor receptor bindingIntegral to plasma membraneHematopoietic cell lineageInterleukin 1 receptor, type IInterleukin-1-mediated signaling pathway 2.60.40.10 112 11 85 3.50 4.08
2ifgA02 79.23 High affinity nerve growth factor receptorIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiens 2.60.40.10 90 14 83 3.27 3.93
1vcaA02 79.20 Vascular cell adhesion protein 1MicrovillusPositive regulation of T cell proliferationMembrane to membrane dockingLeukocyte transendothelial migration 2.60.40.10 110 15 88 3.95 4.48
1f97A01 79.00 Mus musculusEpithelial cell differentiationJunctional adhesion molecule ACell adhesionTight junction 2.60.40.10 102 10 79 3.46 4.36
1nkrA01 78.97 Integral to plasma membraneReceptor activityHomo sapiensNatural killer cell inhibitory signaling pathwayImmune response 2.60.40.10 97 4 88 4.07 4.62
1koaA03 78.69 Caenorhabditis elegansProtein ZK617.1b, partially confirmed by transcript evidenceLocomotionReproduction 2.60.40.10 96 11 80 2.93 3.65
2ec8A04 78.57 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 100 17 92 4.27 4.64
1p53A01 78.53 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 98 9 87 3.95 4.53
1v05A00 78.41 Plasma membraneFilamin-CHomo sapiens 2.60.40.10 96 11 88 4.29 4.87
1g0dA04 78.33 Protein-glutamine gamma-glutamyltransferase 2Pagrus major 2.60.40.10 97 6 91 4.16 4.57
2q8bH01 78.30 2.60.40.10 112 9 73 3.18 4.34
1pewA00 78.28 Ig lambda chain V-VI region SUTHomo sapiens 2.60.40.10 108 11 79 3.39 4.26
1cs6A04 78.21 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 90 13 78 3.15 4.03
3cafA01 78.15 Cell surfacePathways in cancerNucleusPositive regulation of cell proliferationFibroblast growth factor binding 2.60.40.10 96 9 79 3.55 4.48
2gy5A04 78.08 MicrovillusCell surfaceTransmembrane receptor protein tyrosine kinase signaling pathwaySignal transductionProtein binding 2.60.40.10 99 10 89 3.93 4.41
1iarB01 78.06 Jak-STAT signaling pathwayInterleukin 4 receptorIntegral to plasma membraneInterleukin-4 receptor activityHematopoietic cell lineage 2.60.40.10 96 5 80 3.74 4.66
2cqvA00 77.91 Myosin light chain kinase activityProtein phosphorylationHomo sapiensMyosin light chain kinase, smooth muscle 2.60.40.10 114 15 76 3.28 4.30
1xauA00 77.85 Integral to plasma membraneReceptor activityNegative regulation of B cell proliferationProtein bindingMus musculus 2.60.40.10 104 13 85 3.91 4.57
2qsqB01 77.61 Carcinoembryonic antigen-related cell adhesion molecule 5Integral to plasma membraneHomo sapiensBasolateral plasma membrane 2.60.40.10 108 5 75 3.59 4.79
2otuA00 77.60 2.60.40.10 115 11 74 3.37 4.51
1rhfA02 77.60 Integral to plasma membraneTyrosine-protein kinase receptor TYRO3Cell adhesionTYRO3 protein tyrosine kinase 3 [EC:2.7.10.1]Signal transduction 2.60.40.10 84 17 80 3.77 4.70
1iilG02 77.60 Cell surfacePathways in cancerNucleusPositive regulation of cell proliferationFibroblast growth factor binding 2.60.40.10 107 11 76 3.61 4.71
2vxtH01 77.59 2.60.40.10 113 8 73 3.36 4.57
1yc7A00 77.59 2.60.40.10 116 11 75 3.53 4.71
2v44A02 77.57 Prion diseasesNeural cell adhesion moleculePlasma membraneNeuron cell-cell adhesionNeural cell adhesion molecule 2 2.60.40.10 93 10 80 3.23 4.03
1mfaH01 77.56 2.60.40.10 97 8 70 3.17 4.51
1nctA00 77.55 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 2.60.40.10 98 15 86 3.96 4.60
2v44A01 77.50 Prion diseasesNeural cell adhesion moleculeNeuron cell-cell adhesionPlasma membraneNeural cell adhesion molecule 2 2.60.40.10 94 9 84 3.61 4.29
2ak4D01 77.49 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 114 9 76 3.50 4.59
1ogaD02 77.48 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 90 15 79 3.78 4.77
1qz1A03 77.34 Rattus norvegicusPrion diseasesNeural cell adhesion moleculePlasma membraneFibroblast growth factor receptor binding 2.60.40.10 95 13 82 3.75 4.56
2ialA01 77.31 Homo sapiensT-cell receptor alpha chain C region 2.60.40.10 108 13 78 3.28 4.17
2ec8A05 77.28 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Extracellular spaceAcute myeloid leukemia 2.60.40.10 81 12 78 3.41 4.36
1cs6A02 77.27 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 89 10 78 3.37 4.31
1bihA03 77.16 Hyalophora cecropiaHemolin 2.60.40.10 100 4 86 3.77 4.38
3hn3A02 77.09 Beta-glucuronidaseGlycosaminoglycan degradationGlycosaminoglycan catabolic processMetabolic pathwaysStarch and sucrose metabolism 2.60.40.320 103 8 81 3.78 4.63
1neuA00 76.98 Rattus norvegicusMyelin protein P0 2.60.40.10 115 9 72 3.09 4.28
2q0zX03 76.88 ATP-dependent helicase activityPre-mRNA-splicing helicase BRR2 [EC:3.6.1.-]Protein bindingU5 small nuclear ribonucleoprotein 200 kDa helicaseU5 snRNP 2.60.40.150 113 7 78 3.65 4.63
3bp6A00 76.82 Mus musculusExternal side of plasma membraneProgrammed cell death protein 1Programmed cell death protein 1T cell receptor signaling pathway 2.60.40.10 111 9 76 3.54 4.62
1u3hA00 76.71 Mus musculusTRAV14-3 2.60.40.10 110 12 77 3.55 4.59
1kgcE01 76.59 T-cell receptor beta-1 chain C regionHomo sapiensProtein binding 2.60.40.10 112 11 74 3.61 4.87
1jz7A02 76.59 Galactose metabolismSphingolipid metabolismOther glycan degradationMetabolic pathwaysLactose catabolic process 2.60.40.320 114 14 85 3.96 4.65
1ugnA01 76.44 Homo sapiensLeukocyte immunoglobulin-like receptor subfamily B member 1Integral to membraneResponse to virusProtein phosphatase 1 binding 2.60.40.10 95 3 85 4.09 4.80
2gysB04 76.43 Jak-STAT signaling pathwayCytokine receptor common subunit betaApoptosisCytokine-cytokine receptor interactionGranulocyte macrophage colony-stimulating factor receptor complex 2.60.40.10 99 6 78 3.86 4.93
3cmgA04 76.30 Putative beta-galactosidaseBacteroides fragilis NCTC 9343 2.60.40.1560 87 8 74 3.59 4.83
1gl4B00 76.30 Chondrocyte differentiationCardiac muscle tissue developmentCartilage development involved in endochondral bone morphogenesisProtein localizationBrain development 2.60.40.10 89 15 82 3.86 4.70
2c5dC01 76.24 Integral to plasma membraneTransmembrane receptor protein tyrosine kinase activityHomo sapiensTyrosine-protein kinase receptor UFOSignal transduction 2.60.40.10 104 13 90 3.95 4.37
1iamA01 76.00 Leukocyte migrationAdhesion to symbiontHeterophilic cell-cell adhesionRegulation of leukocyte mediated cytotoxicityT cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 2.60.40.10 83 6 77 3.77 4.88
1cczA01 75.96 Homo sapiensLymphocyte function-associated antigen 3Protein binding 2.60.40.10 93 5 77 3.84 4.97
1olzA03 75.91 Anti-apoptosisReceptor bindingSemaphorin-4DReceptor activityCell adhesion 2.60.40.10 89 17 74 3.50 4.71
1cczA02 75.87 Homo sapiensLymphocyte function-associated antigen 3Protein binding 2.60.40.10 78 5 72 3.45 4.77
1tvdA00 75.81 Homo sapiensHDV103S1 2.60.40.10 116 12 75 3.67 4.89
1qfoC00 75.71 Mus musculusSialoadhesinProtein binding 2.60.40.10 114 7 74 3.36 4.51
1eajB00 75.68 Integral to plasma membraneReceptor activityCoxsackievirus and adenovirus receptorViral myocarditisCoxsackievirus and adenovirus receptor 2.60.40.10 120 15 72 3.62 4.99
2aepL01 75.45 2.60.40.10 119 8 69 3.35 4.80
1lp9E01 75.43 2.60.40.10 113 12 76 3.43 4.51
1pkoA00 75.36 Rattus norvegicusMyelin-oligodendrocyte glycoproteinPositive regulation of MyD88-dependent toll-like receptor signaling pathway 2.60.40.10 123 12 72 3.49 4.82
1hxmB01 75.35 Homo sapiensT-cell receptor gamma-2 chain C region 2.60.40.10 125 19 71 3.45 4.85
1t0pB00 75.26 Integral to plasma membraneIntercellular adhesion molecule 3Homo sapiensIntercellular adhesion molecule 3Cell adhesion molecules (CAMs) 2.60.40.10 86 6 82 3.98 4.84
1cs6A03 75.19 Cell adhesion molecule bindingContactin 2Neuron cell-cell adhesionGallus gallusContactin-2 2.60.40.10 98 13 86 4.01 4.66
1mspB00 75.01 Major sperm protein isoform alphaAscaris suum 2.60.40.360 122 3 77 3.77 4.89
1l6zA02 74.89 Mus musculusCarcinoembryonic antigen-related cell adhesion molecule 1 2.60.40.10 96 9 82 3.36 4.09
1im3D00 74.67 Unique short US2 glycoproteinHuman herpesvirus 5 strain AD169 2.60.40.1200 95 7 84 3.63 4.31
2qsvA02 74.53 Porphyromonas gingivalisPutative uncharacterized protein 2.60.40.360 104 5 92 4.21 4.56
1dqtA00 74.53 Mus musculusExternal side of plasma membraneCytotoxic T-lymphocyte protein 4 2.60.40.10 117 10 75 3.44 4.57
2q87C00 74.41 Homo sapiensCMRF35-like molecule 8CD300 antigen 2.60.40.10 106 5 75 3.63 4.81
2xg5A01 74.19 Chaperone protein PapDChaperone protein papDEscherichia coli 2.60.40.360 121 5 72 3.53 4.85
1bihA02 74.10 Hyalophora cecropiaHemolin 2.60.40.10 106 9 76 3.50 4.58
2mcmA00 73.70 MacromomycinStreptomyces macromomyceticus 2.60.40.230 112 9 79 3.80 4.78
1l3wA05 71.50 EP-cadherinXenopus laevis 2.60.40.60 107 9 84 3.95 4.70
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Displaying entries 1 to 115 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1gafH02
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT
YICNVNHKPSNTKVDKKVEP
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1gafH02
ASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQT
YICNVNHKPSNTKVDKKVEP
BLAST against CATH

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Domain History Events (2)

Domain assigned by lewis on 18 Jan 2007 19:12

Reassigning this domain to its previous classification as part of fragment fixing process in preparation for release v3.1.0.

Insertion by lewis on 18 Jan 2007 19:12

Rechopping chains just before release v3.1.0 in order to fix missing fragments.