CATH Domain: 1fmkA03 XML data for domain: 1fmkA03

Molscript image for 1fmkA03
1fmkA03
PDB coordinates for domain 1fmkA03

PDB 1fmk, Chain A, Domain 3

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.30 2-Layer Sandwich
3.30.200 Phosphorylase Kinase; domain 1
3.30.200.20 Phosphorylase Kinase; domain 1 Gene3D
3.30.200.20.16
3.30.200.20.16.1
3.30.200.20.16.1.1
3.30.200.20.16.1.1.1
3.30.200.20.16.1.1.1.1

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Segment boundaries for domain 1fmkA03

Chopping figure for domain 1fmkA03
DomainStart PDB ResidueStop PDB Residue
1fmkA01 82 145
1fmkA02 146 246
1fmkA03 259 344
1fmkA04 345 519

Structural Neighbourhood (54 entries)

There are 54 matching structural neighberhood comparisons for CATH ID 3.30.200.20.16.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 54 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1qpcA01 90.58 Pericentriolar materialPhosphoinositide 3-kinase bindingCD8 receptor bindingT cell receptor signaling pathwayCD4 receptor binding 3.30.200.20 88 61 93 1.88 2.02
2rgpA01 90.32 Calcium signaling pathwayPositive regulation of nitric oxide biosynthetic processEpidermal growth factor receptor activityResponse to UV-APositive regulation of cyclin-dependent protein kinase activity involved in G1/S 3.30.200.20 82 24 91 2.14 2.33
3c4cA01 88.62 Neurotrophin signaling pathwayNon-small cell lung cancerCytoplasmErbB signaling pathwayProtein phosphorylation 3.30.200.20 86 29 95 2.27 2.38
2r3iA01 87.93 Progesterone-mediated oocyte maturationPathways in cancerSmall cell lung cancerOocyte meiosisProstate cancer 3.30.200.20 76 26 86 1.52 1.77
1xbbA01 87.86 T cell receptor complexTyrosine-protein kinase SYKOrgan morphogenesisLeukocyte cell-cell adhesionCell proliferation 3.30.200.20 83 32 91 2.52 2.74
1s9jA01 87.71 Prion diseasesNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 3.30.200.20 86 19 95 2.14 2.24
2weiA01 87.68 Cryptosporidium parvum Iowa IICalmodulin-domain protein kinase 1, putative 3.30.200.20 90 25 94 2.98 3.16
1tkiA01 87.53 Structural constituent of muscleCalcium ion bindingSarcomere organizationTelethonin bindingActin filament binding 3.30.200.20 84 19 95 2.75 2.88
1ob3A01 87.38 Cyclin-dependent kinase [EC:2.7.11.22]Cell division control protein 2 homologPlasmodium falciparum K1 3.30.200.20 83 24 91 2.19 2.38
3eqrB01 87.32 Activated CDC42 kinase 1GTPase inhibitor activitySmall GTPase mediated signal transductionHomo sapiensPositive regulation of peptidyl-tyrosine phosphorylation 3.30.200.20 91 40 87 2.42 2.75
3f3zA01 86.92 Cryptosporidium parvum Iowa IICalcium-dependent protein kinase [EC:2.7.11.1]Calcium/calmodulin-dependent protein kinase with a kinase domain and 4 calmodulin like EF hands 3.30.200.20 81 30 91 2.40 2.61
2evaA01 86.79 Positive regulation of T cell cytokine productionActivation of NF-kappaB-inducing kinase activityPositive regulation of interleukin-2 productionMitogen-activated protein kinase kinase kinase 7Protein binding 3.30.200.20 82 25 94 2.46 2.61
1lufA01 86.58 Muscle, skeletal receptor tyrosine protein kinaseReceptor clusteringRattus norvegicusResponse to muscle activityMemory 3.30.200.20 97 27 84 2.33 2.76
1zy4A01 86.42 Eukaryotic translation initiation factor 2alpha kinase activityProtein bindingSerine/threonine-protein kinase GCN2DNA damage checkpointRegulation of translational initiation 3.30.200.20 94 25 90 3.20 3.54
3e64A01 86.07 Jak-STAT signaling pathwayCellular component movementTyrosine-protein kinase JAK2Chemokine signaling pathwayAdipocytokine signaling pathway 3.30.200.20 93 24 88 2.38 2.70
2jamA01 86.05 Calcium/calmodulin-dependent protein kinase type 1GHomo sapiensCalcium/calmodulin-dependent protein kinase I [EC:2.7.11.17] 3.30.200.20 75 26 84 2.75 3.24
2h6dA01 86.01 Insulin signaling pathwayHypertrophic cardiomyopathy (HCM)Adipocytokine signaling pathwayRegulation of autophagyMTOR signaling pathway 3.30.200.20 86 29 93 3.95 4.25
3bceA01 85.85 Receptor tyrosine-protein kinase erbB-4Transmembrane receptor protein tyrosine kinase activityHomo sapiensBasolateral plasma membraneProtein binding 3.30.200.20 94 30 87 2.45 2.81
3c0iA01 85.83 Actin cytoskeletonGuanylate kinase activityPeripheral plasma membrane protein CASKCell adhesionHomo sapiens 3.30.200.20 88 22 90 2.83 3.11
2rkuA01 85.77 Polo-like kinase 1 [EC:2.7.11.21]Polo kinase kinase activityProgesterone-mediated oocyte maturationCell proliferationOocyte meiosis 3.30.200.20 89 16 93 2.56 2.75
2j51A01 85.70 CytoplasmOocyte meiosisSTE20-like serine/threonine-protein kinasePlasma membraneHomo sapiens 3.30.200.20 90 17 91 2.76 3.03
3blhA01 85.65 Transcription elongation from RNA polymerase II promoterCyclin-dependent protein kinase activityRNA polymerase II carboxy-terminal domain kinase activityProtein bindingCell proliferation 3.30.200.20 86 25 94 3.22 3.42
3fpqA01 85.63 Rattus norvegicusSerine/threonine-protein kinase WNK1Protein bindingPotassium channel inhibitor activityATP binding 3.30.200.20 91 25 87 4.32 4.91
3comB01 85.61 Transcription factor bindingPathways in cancerNon-small cell lung cancerCytoplasmSerine/threonine-protein kinase 4 3.30.200.20 85 22 89 2.83 3.16
3hmmA01 85.41 Type II transforming growth factor beta receptor bindingPeptidyl-threonine phosphorylationPositive regulation of cellular component movementPathway-restricted SMAD protein phosphorylationResponse to cholesterol 3.30.200.20 84 25 91 2.87 3.12
2acxA02 85.35 G protein-coupled receptor kinase 6Homo sapiensRegulation of G-protein coupled receptor protein signaling pathway 3.30.200.20 91 23 93 2.68 2.87
2zv2A01 85.19 Calcium ion bindingRegulation of protein kinase activityPositive regulation of transcriptionMAPKKK cascadeCytoplasm 3.30.200.20 77 25 84 3.01 3.55
2vgpB01 85.18 Serine/threonine-protein kinase 12-AHistone H3-S10 phosphorylationChromosome, centromeric regionProtein bindingChromatin 3.30.200.20 89 20 93 2.69 2.88
2wtjA01 85.12 DNA damage response, signal transduction resulting in induction of apoptosisSenescenceSerine/threonine-protein kinase Chk2PML bodyProtein binding 3.30.200.20 79 24 87 3.85 4.41
2wtkC01 85.10 NucleusSerine/threonine-protein kinase 11Cell cycle arrestProtein bindingSerine/threonine-protein kinase 11 [EC:2.7.11.9] 3.30.200.20 89 26 89 4.23 4.71
2clqA01 84.98 Induction of apoptosis by extracellular signalsProtein homodimerization activityMitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]Neurotrophin signaling pathwayATP binding 3.30.200.20 85 28 88 2.85 3.23
3d5vA01 84.57 Danio rerioPolo-like kinase 3.30.200.20 92 17 90 3.20 3.55
2ac3A01 84.52 MAP kinase-interacting serine/threonine-protein kinase 2ATP bindingProtein phosphorylationHomo sapiensProtein serine/threonine kinase activity 3.30.200.20 80 18 87 2.19 2.51
1fvrA01 84.50 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 86 16 91 3.36 3.66
1q5kA01 84.49 Hedgehog signaling pathwayNeurotrophin signaling pathwayAlzheimer's diseaseT cell receptor signaling pathwayER overload response 3.30.200.20 95 23 85 3.12 3.66
2oibA01 84.41 Chagas diseaseNeurotrophin signaling pathwayInterleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]ApoptosisHomo sapiens 3.30.200.20 93 29 81 2.85 3.49
1x8bA01 84.01 Homo sapiensWee1-like protein kinaseProtein binding 3.30.200.20 84 20 91 4.45 4.84
1kobA01 83.96 Aplysia californicaTwitchin-like protein 3.30.200.20 109 18 77 2.19 2.84
2qkwB01 83.89 Solanum pimpinellifoliumProtein kinaseProtein binding 3.30.200.20 72 27 81 2.37 2.91
2dylA01 83.65 Mitogen-activated protein kinase kinase 7 [EC:2.7.12.2]MAP kinase kinase activityNeurotrophin signaling pathwayStress-activated MAPK cascadeT cell receptor signaling pathway 3.30.200.20 91 15 84 4.13 4.88
3fhrA01 83.63 Response to stressMAP kinase kinase activityNucleusMitogen-activated protein kinase-activated protein kinase 3 [EC:2.7.11.1]MAPK signaling pathway 3.30.200.20 80 16 86 3.15 3.66
2w5aA01 83.62 NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]Regulation of mitosisSerine/threonine-protein kinase Nek2CentrosomeCentrosome separation 3.30.200.20 64 21 69 1.83 2.62
2a19C01 83.59 Eukaryotic translation initiation factor 2alpha kinase activityProtein phosphatase type 2A regulator activityInterferon-induced, double-stranded RNA-activated protein kinaseProtein bindingNegative regulation of osteoblast proliferation 3.30.200.20 95 18 86 4.22 4.89
3g51A01 83.47 Progesterone-mediated oocyte maturationNeurotrophin signaling pathwayOocyte meiosisMAPK signaling pathwayLong-term potentiation 3.30.200.20 95 18 81 3.26 4.02
1xwsA01 83.41 Transcription factor bindingPositive regulation of cyclin-dependent protein kinase activity involved in G1/SManganese ion bindingNegative regulation of apoptosisProtein binding 3.30.200.20 92 19 88 2.93 3.33
1u5qA01 82.92 Rattus norvegicusThousand and one amino acid protein kinase [EC:2.7.11.1]Serine/threonine-protein kinase TAO2MAPK signaling pathway 3.30.200.20 96 20 83 2.60 3.12
1o6lA02 82.14 Jak-STAT signaling pathwayRAC-beta serine/threonine-protein kinaseNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathway 3.30.200.20 117 22 71 2.42 3.37
1rdqE02 81.16 Calcium signaling pathwayPrion diseasesProtein kinase A [EC:2.7.11.11]Olfactory transductionMesoderm formation 3.30.200.20 124 22 69 3.08 4.44
3h9rA01 80.53 Positive regulation of osteoblast differentiationBMP signaling pathwayActivin bindingNegative regulation of apoptosisNegative regulation of activin receptor signaling pathway 3.30.200.20 113 23 72 2.77 3.82
2f57B01 79.78 T cell receptor signaling pathwayP21-activated kinase 7 [EC:2.7.11.1]Protein bindingRenal cell carcinomaErbB signaling pathway 3.30.200.20 106 23 77 3.48 4.50
3g0eA01 79.32 Pathways in cancerHematopoietic cell lineageProto-oncogene tyrosine-protein kinase Kit [EC:2.7.10.1]Protein bindingAcute myeloid leukemia 3.30.200.20 131 33 62 2.31 3.69
1ckiA01 79.11 SpindleRattus norvegicusHedgehog signaling pathwaySoluble fractionCircadian rhythm - mammal 3.30.200.20 64 20 73 3.55 4.85
3a8xB01 78.84 Tight junctionInsulin signaling pathwayEndocytosisVesicle-mediated transportProtein binding 3.30.200.20 130 20 66 3.01 4.55
2oo8X01 78.30 Cell surfaceMicrovillusTransmembrane receptor protein tyrosine kinase signaling pathwayProtein bindingSignal transduction 3.30.200.20 60 25 68 3.07 4.47
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Displaying entries 1 to 54 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1fmkA03
AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVT
EYMSKG
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1fmkA03
AWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVT
EYMSKG
BLAST against CATH

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Domain History Events (4)

Update comment by auto on 16 Oct 2007 19:44

Around September/October 2007, this domain was renamed from "1fmk003" to "1fmkA03" as part of the work to deal with the remediation of the PDB (see http://remediation.wwpdb.org). Please see ticket:207 or wiki:Remediation on the CATH Trac system for more details.

Set cath from cathlist by auto on 05 Mar 2006 19:02

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 19:02

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 16:33

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"