CATH Domain: 1fgyA00 XML data for domain: 1fgyA00

Molscript image for 1fgyA00
1fgyA00
PDB coordinates for domain 1fgyA00

PDB 1fgy, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.3
2.30.29.30.3.1
2.30.29.30.3.1.1
2.30.29.30.3.1.1.1
2.30.29.30.3.1.1.1.1

[top]
Segment boundaries for domain 1fgyA00

Chopping figure for domain 1fgyA00
DomainStart PDB ResidueStop PDB Residue
1fgyA00 261 386

Structural Neighbourhood (35 entries)

There are 35 matching structural neighberhood comparisons for CATH ID 2.30.29.30.3.1.1.1.1 (SIMAX score < 5)

[1]
Displaying entries 1 to 35 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1faoA00 87.90 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 33 78 2.06 2.63
1upqA00 87.00 Pleckstrin homology domain-containing family A member 4Homo sapiens 2.30.29.30 107 21 78 1.70 2.17
1eazA00 86.89 NucleusPleckstrin homology domain-containing family A member 1B cell receptor signaling pathwayPhosphatidylinositol-3,4-bisphosphate bindingRuffle organization 2.30.29.30 103 30 78 1.72 2.19
1u5dA00 85.97 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 22 79 1.97 2.49
1v89A00 85.91 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 27 88 3.44 3.87
2dn6A00 85.74 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 23 82 2.63 3.19
3cxbB00 85.05 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 21 76 2.33 3.07
2i5fA00 84.86 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayActin cytoskeleton reorganizationHemopoietic progenitor cell differentiationRuffle organization 2.30.29.30 92 33 73 2.19 2.98
2dhjA00 84.75 Rho GTPase-activating protein 21Homo sapiens 2.30.29.30 125 15 82 3.55 4.31
1dynA00 84.70 GTPase activityReceptor-mediated endocytosisHomo sapiensDynamin-1Protein binding 2.30.29.30 113 20 86 4.09 4.73
1ntyA02 84.48 Triple functional domain protein [EC:2.7.11.-]Triple functional domain proteinHomo sapiensProtein serine/threonine kinase activityTransmembrane receptor protein tyrosine phosphatase signaling pathway 2.30.29.30 124 12 83 2.70 3.25
1v88A00 84.31 Oxysterol-binding protein-related protein 8Homo sapiens 2.30.29.30 130 19 93 4.62 4.96
1btnA00 84.07 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 15 72 2.07 2.88
1qqgA01 84.04 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 22 71 1.62 2.28
1txdA02 83.93 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 15 82 2.98 3.62
1omwA05 83.56 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 19 76 2.20 2.86
2coaA01 82.65 Homo sapiensSerine/threonine-protein kinase D2 2.30.29.30 118 17 78 2.53 3.23
1qqgA02 82.26 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 7 78 2.80 3.57
1plsA00 82.17 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 21 83 3.22 3.87
1dbhA02 82.05 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 15 75 3.33 4.43
2rgnB02 81.86 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 11 81 3.76 4.61
2p8vA00 81.76 Homer protein homolog 3Metabotropic glutamate receptor signaling pathwayProtein targetingHomo sapiensProtein binding 2.30.29.30 117 5 78 2.85 3.64
1kz7C02 81.76 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 13 75 3.03 4.02
1rrpB00 81.59 E3 SUMO-protein ligase RanBP2Ran GTPase bindingNuclear poreProtein import into nucleusHomo sapiens 2.30.29.30 134 7 76 2.58 3.36
1w1hD00 81.28 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 16 67 2.33 3.43
1evhA00 81.18 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 4 75 2.81 3.74
1ddwA00 81.09 DendriteType 5 metabotropic glutamate receptor bindingRattus norvegicusResponse to cocaineResponse to stress 2.30.29.30 109 4 75 2.73 3.63
1zsqA01 80.78 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 8 74 3.40 4.57
1btkA00 80.20 Induction of apoptosis by extracellular signalsPhosphatidylinositol-3,4,5-trisphosphate bindingIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.29.30 160 17 63 2.76 4.37
1p5tA00 78.94 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity 2.30.29.30 105 9 76 3.57 4.65
1ef1A03 78.93 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 10 74 2.57 3.45
1q67A01 78.31 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 7 65 3.09 4.70
1mixA02 77.39 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 16 72 3.35 4.65
1xr0B01 77.07 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 10 71 3.24 4.55
1mkeA00 76.26 Rattus norvegicusNeural Wiskott-Aldrich syndrome protein 2.30.29.30 144 8 65 3.19 4.84
[1]
Displaying entries 1 to 35 (page 1 of 1)


[top]
Domain ATOM Sequence 

>pdb|1fgyA00
TFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVLDPRKPNCFELYNPSHKGQVIK
ACKTEADGRVVEGNHVVYRISAPSPEEKEEWKSIKASISRDPFYD
BLAST against CATH

[top]
Domain COMBS Sequence 

>pdb|1fgyA00
TFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVLDPRKPNCFELYNPSHKGQVIK
ACKTEADGRVVEGNHVVYRISAPSPEEKEEWXKSIKASISRDPFYDX
BLAST against CATH

[top]
Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:23

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:23

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 14:47

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"