CATH Domain: 1ek6A02 XML data for domain: 1ek6A02

Molscript image for 1ek6A02
1ek6A02
PDB coordinates for domain 1ek6A02

PDB 1ek6, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
3 Alpha Beta
3.40 3-Layer(aba) Sandwich
3.40.50 Rossmann fold
3.40.50.720 NAD(P)-binding Rossmann-like Domain Gene3D
3.40.50.720.18
3.40.50.720.18.1
3.40.50.720.18.1.1
3.40.50.720.18.1.1.1
3.40.50.720.18.1.1.1.1

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Segment boundaries for domain 1ek6A02

Chopping figure for domain 1ek6A02
DomainStart PDB ResidueStop PDB Residue
1ek6A01 190 239
1ek6A01 271 346
1ek6A02 3 189
1ek6A02 240 270

Structural Neighbourhood (50 entries)

There are 50 matching structural neighberhood comparisons for CATH ID 3.40.50.720.18.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 50 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1i24A01 87.34 Amino sugar and nucleotide sugar metabolismZinc ion bindingGlycolipid biosynthetic processChloroplastSulfotransferase activity 3.40.50.720 235 23 87 2.33 2.66
1n7hA02 86.92 Amino sugar and nucleotide sugar metabolismGDPmannose 4,6-dehydratase [EC:4.2.1.47]Fructose and mannose metabolismCytosolMetabolic pathways 3.40.50.720 231 19 87 2.29 2.62
1eq2A01 85.64 Metabolic pathwaysLipopolysaccharide biosynthesisMembraneProtein bindingADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20] 3.40.50.720 202 23 86 2.44 2.83
1vl0B01 85.31 DTDP-4-dehydrorhamnose reductase, rfbD orthologDTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]Streptomycin biosynthesisMetabolic pathwaysPolyketide sugar unit biosynthesis 3.40.50.720 200 19 81 1.87 2.29
1wvgA01 84.74 3.40.50.720 193 23 79 2.57 3.22
1kbzA01 84.71 Streptomycin biosynthesisMetabolic pathwaysPolyketide sugar unit biosynthesisDTDP-4-dehydrorhamnose reductaseSalmonella enterica subsp. enterica serovar Typhimurium 3.40.50.720 213 16 85 2.66 3.12
2hrzA01 84.55 Agrobacterium tumefaciens str. C58Nucleoside-diphosphate-sugar epimerase 3.40.50.720 224 18 85 3.14 3.66
2bllA01 83.97 Amino sugar and nucleotide sugar metabolismOxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorHydroxymethyl-, formyl- and related transferase activityUDP-GlcUA decarboxylase/UDP-L-Ara4N formyltransferase [EC:1.1.1.- 2.1.2.-]Bifunctional polymyxin resistance protein ArnA 3.40.50.720 243 18 83 2.55 3.07
3e8xA00 83.64 BH1520 proteinBacillus halodurans 3.40.50.720 204 15 77 2.40 3.08
3grpD00 83.52 3-oxoacyl-(Acyl carrierprotein) reductaseBartonella henselae3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]Fatty acid biosynthesisBiosynthesis of unsaturated fatty acids 3.40.50.720 209 13 83 2.75 3.29
2ag5C00 83.39 NAD or NADH bindingMetabolic pathwaysButanoate metabolismCytoplasm3-hydroxybutyrate dehydrogenase type 2 3.40.50.720 244 9 79 2.90 3.67
2ew8B00 83.30 Ethylbenzene degradation(S)-1-Phenylethanol dehydrogenaseAromatoleum aromaticum EbN1 3.40.50.720 228 11 86 3.48 4.03
2a4kB01 83.04 3.40.50.720 196 16 78 2.78 3.54
1gz6B01 82.64 PeroxisomeRattus norvegicusPrimary bile acid biosynthesis3(or 17)beta-hydroxysteroid dehydrogenase activityPeroxisomal multifunctional enzyme type 2 3.40.50.720 219 14 88 2.88 3.27
1ydeN00 82.56 17-beta-hydroxysteroid dehydrogenase 14Testosterone 17-beta-dehydrogenase (NADP+) activityEstradiol 17-beta-dehydrogenase activitySteroid catabolic processHomo sapiens 3.40.50.720 240 15 80 2.57 3.21
2o23A00 82.52 3-hydroxyacyl-CoA dehydrogenase type-2Lipid metabolic process7-alpha-hydroxysteroid dehydrogenase activityPlasma membraneHomo sapiens 3.40.50.720 241 12 77 2.57 3.33
1zk4A00 82.47 Lactobacillus brevisR-specific alcohol dehydrogenase 3.40.50.720 244 13 79 3.16 4.00
1xg5B00 82.34 Dehydrogenase/reductase SDR family member 11Homo sapiens 3.40.50.720 241 13 80 3.64 4.52
2z1nA00 82.29 Aeropyrum pernix3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]Putative dehydrogenaseFatty acid biosynthesisBiosynthesis of unsaturated fatty acids 3.40.50.720 237 14 83 3.04 3.64
2ztuB00 82.27 Pseudomonas fragiD(-)-3-hydroxybutyrate dehydrogenase 3.40.50.720 207 11 81 3.43 4.22
1hxhA00 82.23 3-beta-hydroxysteroid dehydrogenaseComamonas testosteroni 3.40.50.720 253 11 76 2.67 3.48
1spxA00 82.22 Caenorhabditis elegansProtein D1054.8, confirmed by transcript evidenceDetermination of adult lifespan 3.40.50.720 237 12 82 3.05 3.71
3d7lA00 82.15 Listeria innocuaLin1944 protein 3.40.50.720 196 9 80 3.14 3.91
2dknB00 82.06 3-alpha-hydroxysteroid dehydrogenasePseudomonas sp. B-0831 3.40.50.720 226 12 77 2.98 3.83
1zemA00 82.02 Gluconobacter oxydansXylitol dehydrogenase 3.40.50.720 260 16 76 3.08 4.02
1iy8A00 82.02 Leifsonia aquaticaLevodione reductase 3.40.50.720 258 14 76 2.65 3.45
1cydA00 81.79 Carbonyl reductase (NADPH) activityArachidonic acid metabolismProtein tetramerizationCarbonyl reductase [NADPH] 2Metabolic pathways 3.40.50.720 242 14 80 3.31 4.11
1sbyA00 81.74 Scaptodrosophila lebanonensisAlcohol dehydrogenase 3.40.50.720 252 14 75 2.34 3.09
2rhcA00 81.65 Putative ketoacyl reductaseBiosynthesis of type II polyketide backboneStreptomyces coelicolorKetoacyl reductase [EC:1.3.1.-] 3.40.50.720 257 16 77 3.31 4.27
3gemD00 81.59 Pseudomonas syringae pv. phaseolicola 1448A[EC:1.-.-.-]Oxidoreductase, short chain dehydrogenase/reductase family 3.40.50.720 209 12 86 3.06 3.53
2p91C00 81.58 Enoyl-[acyl-carrier-protein] reductase [NADH]Aquifex aeolicus 3.40.50.720 228 11 85 3.33 3.87
2zatA00 81.50 PeroxisomeDehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]Sus scrofaDehydrogenase/reductase SDR family member 4Retinol metabolism 3.40.50.720 251 14 79 3.33 4.20
1fmcA00 81.40 7-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.159]7-alpha-hydroxysteroid dehydrogenaseEscherichia coli K-12Cytosol 3.40.50.720 255 13 78 3.42 4.38
1xq6A00 81.33 Arabidopsis thalianaResponse to abscisic acid stimulusUncharacterized protein At5g02240Plasma membraneApoplast 3.40.50.720 253 15 71 2.83 3.93
1geeA00 81.23 Bacillus megateriumGlucose 1-dehydrogenase 3.40.50.720 261 12 75 2.66 3.51
1bdbA00 81.17 Biphenyl degradationCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase [EC:1.3.1.56]Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenaseBurkholderia xenovorans LB400Metabolic pathways 3.40.50.720 267 15 73 3.22 4.39
1xq1A00 81.13 Arabidopsis thalianaTropinone reductase homolog At1g07440Response to cadmium ion 3.40.50.720 218 13 84 3.13 3.69
2qq5A00 80.86 NucleusGolgi apparatusEndoplasmic reticulumHomo sapiensDehydrogenase/reductase SDR family member 1 3.40.50.720 238 14 83 3.11 3.74
1xu9C00 80.63 Aldosterone-regulated sodium reabsorptionCorticosteroid 11-beta-dehydrogenase isozyme 1Homo sapiensSteroid hormone biosynthesis11beta-hydroxysteroid dehydrogenase [EC:1.1.1.146] 3.40.50.720 258 13 75 3.45 4.56
1ja9A00 80.61 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]Fatty acid biosynthesis1,3,6,8-tetrahydroxynaphthalene reductaseBiosynthesis of unsaturated fatty acidsMagnaporthe grisea 3.40.50.720 259 15 77 3.68 4.74
1yxmC00 80.49 PeroxisomePeroxisomal trans-2-enoyl-CoA reductasePeroxisomal trans-2-enoyl-CoA reductase [EC:1.3.1.38]Homo sapiensBiosynthesis of unsaturated fatty acids 3.40.50.720 263 13 69 2.34 3.38
1jtvA00 80.44 CytoplasmEstradiol 17-beta-dehydrogenase 1Homo sapiens 3.40.50.720 278 16 70 2.61 3.70
2x9gD00 80.35 Pteridine reductaseTrypanosoma brucei brucei 3.40.50.720 248 11 79 3.26 4.08
3iccA00 80.23 Bacillus anthracisOxidoreductase, short-chain dehydrogenase/reductase family 3.40.50.720 248 13 78 2.97 3.78
1ooeA00 79.51 Dihydropteridine reductase [EC:1.5.1.34]Caenorhabditis elegansProtein T03F6.1, confirmed by transcript evidenceFolate biosynthesisMetabolic pathways 3.40.50.720 235 13 79 3.71 4.69
1oaaA00 79.43 DeathRegulation of multicellular organism growthProtein homodimerization activitySepiapterin reductasePteridine metabolic process 3.40.50.720 259 13 74 2.85 3.82
1wmaA00 79.19 Arachidonic acid metabolismMetabolic pathwaysCarbonyl reductase (NADPH) activity15-hydroxyprostaglandin dehydrogenase (NADP) [EC:1.1.1.197]Carbonyl reductase [NADPH] 1 3.40.50.720 275 14 72 3.01 4.16
1zmtA00 79.13 3.40.50.720 252 9 78 3.68 4.71
2h7iA00 78.70 Enoyl-[acyl-carrier-protein] reductase [NADH]Enoyl ACP reductase [EC:1.3.1.9]Mycobacterium tuberculosis 3.40.50.720 268 12 72 3.11 4.27
2oosB00 76.33 Enoyl-ACP reductasePlasmodium falciparum 3.40.50.720 283 8 72 3.25 4.51
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Displaying entries 1 to 50 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1ek6A02
EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSF
MAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKF
FIEEMIRDLCQADKTWNAVLLRYFNPTDYIHVVDLAKGHIAALRKLKEQCGCRIYNLG
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1ek6A02
EKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLRRVQELTGRSVEFEEMDILDQGALQRLFKKYSF
MAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMKAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKF
FIEEMIRDLCQADKTWNAVLLRYFNPTDYIHVVDLAKGHIAALRKLKEQCGCRIYNLG
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 19:16

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 19:16

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 16:27

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"