CATH Domain: 1ddwA00 XML data for domain: 1ddwA00

Molscript image for 1ddwA00
1ddwA00
PDB coordinates for domain 1ddwA00

PDB 1ddw, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D
2.30.29.30.11
2.30.29.30.11.1
2.30.29.30.11.1.1
2.30.29.30.11.1.1.1
2.30.29.30.11.1.1.1.1

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Segment boundaries for domain 1ddwA00

Chopping figure for domain 1ddwA00
DomainStart PDB ResidueStop PDB Residue
1ddwA00 2 111

Structural Neighbourhood (32 entries)

There are 32 matching structural neighberhood comparisons for CATH ID 2.30.29.30.11.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 32 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1evhA00 89.79 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization 2.30.29.30 111 29 95 1.85 1.94
1rrpB00 85.70 E3 SUMO-protein ligase RanBP2Ran GTPase bindingNuclear poreProtein import into nucleusHomo sapiens 2.30.29.30 134 21 77 1.70 2.19
1faoA00 84.14 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneB cell receptor signaling pathway 2.30.29.30 100 3 84 3.25 3.85
1qqgA01 83.99 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 103 6 81 2.32 2.84
3cxbB00 83.94 Kinesin bindingPleckstrin homology domain-containing family M member 2Golgi organizationHomo sapiens 2.30.29.30 102 7 85 3.13 3.67
1u5dA00 83.85 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm 2.30.29.30 108 4 88 3.75 4.21
1zsqA01 83.17 [EC:3.1.3.-]NucleusFructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism 2.30.29.30 101 5 79 2.56 3.21
2dn6A00 83.14 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens 2.30.29.30 115 2 80 2.73 3.38
1qqgA02 82.91 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway 2.30.29.30 104 5 88 3.11 3.53
1omwA05 82.45 MembraneNegative regulation of the force of heart contraction by chemical signalG-protein coupled receptor kinase activityChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway 2.30.29.30 101 11 81 3.00 3.67
1v89A00 82.22 Homo sapiensRho GTPase-activating protein 25 2.30.29.30 118 7 80 2.95 3.66
2he7A03 82.08 Tight junctionErythrocyte membrane protein band 4.1Homo sapiensBand 4.1-like protein 3Cell-cell junction 2.30.29.30 95 5 79 2.54 3.18
1btnA00 81.86 Mus musculusSpectrin beta chain, brain 1SMAD protein import into nucleusCuticular platePlasma membrane 2.30.29.30 106 3 82 3.18 3.85
1t77A01 81.83 Lipopolysaccharide-responsive and beige-like anchor proteinHomo sapiensProtein binding 2.30.29.40 105 7 76 2.59 3.40
1dynA00 81.54 GTPase activityReceptor-mediated endocytosisHomo sapiensDynamin-1Protein binding 2.30.29.30 113 3 84 3.85 4.53
1txdA02 81.41 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway 2.30.29.30 121 5 77 2.95 3.80
1q67A01 81.14 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding 2.30.29.30 140 12 72 2.40 3.29
2rgnB02 81.00 Homo sapiensGuanine nucleotide exchange factor GEFT 2.30.29.30 123 9 74 2.41 3.22
2dhjA00 80.93 Rho GTPase-activating protein 21Homo sapiens 2.30.29.30 125 4 78 3.51 4.48
1ef1A03 80.62 Receptor bindingLeukocyte migrationCytoskeletonMembrane to membrane dockingNucleolus 2.30.29.30 95 4 79 3.36 4.21
1plsA00 80.19 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRegulation of cell diameter 2.30.29.30 113 6 81 3.70 4.54
1pfjA00 80.11 Positive regulation of transcription from RNA polymerase II promoterGeneral RNA polymerase II transcription factor activityGeneral transcription factor IIH subunit 1Nucleotide excision repairRegulation of cyclin-dependent protein kinase activity 2.30.29.30 108 7 80 2.96 3.67
1mkeA00 79.99 Rattus norvegicusNeural Wiskott-Aldrich syndrome protein 2.30.29.30 144 14 71 2.71 3.79
1kz7C02 79.78 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium 2.30.29.30 134 4 73 3.54 4.84
1dbhA02 79.41 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancer 2.30.29.30 124 4 68 2.59 3.78
1v88A00 79.31 Oxysterol-binding protein-related protein 8Homo sapiens 2.30.29.30 130 2 72 3.30 4.56
1w1hD00 79.14 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]PPAR signaling pathwayPeptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorptionNon-small cell lung cancer 2.30.29.30 137 9 66 2.20 3.31
1xr0B01 79.08 Fibroblast growth factor receptor substrate 2Membrane fractionIntegral to plasma membraneTransmembrane receptor protein tyrosine kinase adaptor activityNeurotrophin signaling pathway 2.30.29.30 91 4 79 2.88 3.61
1mixA02 78.18 Talin-1Focal adhesionFocal adhesionGallus gallusTalin 2.30.29.30 93 7 82 3.90 4.72
1fhoA00 76.97 Caenorhabditis elegansMuscle M-line assembly protein unc-89Locomotion 2.30.29.30 119 10 78 3.87 4.90
1btkA00 76.94 Induction of apoptosis by extracellular signalsPhosphatidylinositol-3,4,5-trisphosphate bindingIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.29.30 160 2 60 2.72 4.49
1ki1B02 76.44 Synaptic vesicle endocytosisHomo sapiensProtein bindingIntersectin-1 2.30.29.30 142 7 62 3.03 4.83
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Displaying entries 1 to 32 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1ddwA00
GEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNTFTKTSQKFGQWADSRA
NTVYGLGFSSEHHLSKFAEKFQEFKEAAR
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1ddwA00
XGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNXTFTKTSQKFGQWADS
RANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:24

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:24

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 14:47

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"