CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.21
Coagulation factor VIIa.
based on mapping to UniProt P08709
Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.
-!- Formed from the precursor factor VII. -!- The cattle enzyme is more readily inhibited by diisopropyl fluorophosphate than the human. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P08709
FA7_HUMAN
Homo sapiens
Coagulation factor VII

PDB Structure

PDB 1CVW
External Links
Method X-RAY DIFFRACTION
Organism Cricetulus
Primary Citation
Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla).
Kemball-Cook, G., Johnson, D.J., Tuddenham, E.G., Harlos, K.
J.Struct.Biol.