CATH Domain: 1ckaA00 XML data for domain: 1ckaA00

Molscript image for 1ckaA00
1ckaA00
PDB coordinates for domain 1ckaA00

PDB 1cka, Chain A, Domain 0

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.30 SH3 type barrels.
2.30.30.40 SH3 Domains Gene3D
2.30.30.40.18
2.30.30.40.18.1
2.30.30.40.18.1.1
2.30.30.40.18.1.1.1
2.30.30.40.18.1.1.1.1

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Segment boundaries for domain 1ckaA00

Chopping figure for domain 1ckaA00
DomainStart PDB ResidueStop PDB Residue
1ckaA00 134 190

Structural Neighbourhood (72 entries)

There are 72 matching structural neighberhood comparisons for CATH ID 2.30.30.40.18.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 72 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
2vwfA00 93.81 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 56 35 96 1.03 1.07
1ov3A02 93.76 GTP bindingSoluble fractionSH3 domain bindingCellular defense responseSuperoxide anion generation 2.30.30.40 54 18 96 1.19 1.23
1jegA00 92.58 Tyrosine-protein kinase CSKProtein bindingCell-cell junctionMus musculusATP binding 2.30.30.40 60 39 93 0.93 1.00
2j6fA00 92.29 CD2-associated proteinRufflePlasma membraneSH3 domain bindingStructural constituent of cytoskeleton 2.30.30.40 57 28 94 1.29 1.36
2rqtA00 91.78 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing proteinArf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1Fc gamma R-mediated phagocytosisHomo sapiensProtein binding 2.30.30.40 61 19 91 1.32 1.44
1yn8A00 91.73 NucleusHyperosmotic responseResponse to heatNegative regulation of protein kinase activityProtein binding 2.30.30.40 59 30 94 1.22 1.29
1ad5A01 91.10 Protein phosphorylationTyrosine-protein kinase HCKHomo sapiensMesoderm developmentProtein binding 2.30.30.40 63 35 87 1.07 1.23
1x6bA01 90.88 Rho guanine nucleotide exchange factor 16Homo sapiens 2.30.30.40 64 14 85 1.04 1.21
2v1rA00 90.87 PeroxisomePeroxin-13Protein binding, bridgingPeroxisomal membrane protein PAS20Peroxisomal membrane 2.30.30.40 67 37 83 1.06 1.27
1griA01 90.74 Jak-STAT signaling pathwayNeurotrophin signaling pathwayNon-small cell lung cancerT cell receptor signaling pathwayErbB signaling pathway 2.30.30.40 48 41 85 0.89 1.04
2jteA00 90.70 Mus musculusCD2-associated protein 2.30.30.40 64 35 85 1.24 1.44
1wx6A01 90.27 NCK adaptor proteinPositive regulation of T cell proliferationRegulation of epidermal growth factor receptor activityT cell receptor signaling pathwayEpidermal growth factor receptor signaling pathway 2.30.30.40 66 32 84 1.44 1.70
2vknA00 89.97 MAPK signaling pathway - yeastIdentical protein bindingMating projection tipPseudohyphal growthOsmosensor activity 2.30.30.40 66 28 83 1.47 1.76
1ycsB02 89.91 Induction of apoptosisNF-kappaB bindingNegative regulation of cell cycleHomo sapiensApoptosis-stimulating of p53 protein 2 2.30.30.40 64 28 85 1.05 1.22
1ng2A02 89.47 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 68 17 80 1.47 1.82
3ehrB01 89.38 Osteoclast-stimulating factor 1OssificationIdentical protein bindingHomo sapiensSignal transduction 2.30.30.40 62 32 87 1.65 1.89
2csqA01 89.36 RIMS-binding protein 2Homo sapiens 2.30.30.40 65 32 84 1.52 1.80
2ablA01 88.85 DNA damage response, signal transduction resulting in induction of apoptosisProto-oncogene tyrosine-protein kinase ABL1 [EC:2.7.10.2]Pathways in cancerNucleolusNeurotrophin signaling pathway 2.30.30.40 66 25 83 1.43 1.72
1awwA00 88.55 Phosphatidylinositol-3,4,5-trisphosphate bindingInduction of apoptosis by extracellular signalsIdentical protein bindingPlasma membraneB cell receptor signaling pathway 2.30.30.40 67 35 83 1.49 1.78
2js2A00 88.48 Receptor bindingNCK adaptor proteinPositive regulation of T cell proliferationT cell receptor signaling pathwayPositive regulation of actin filament polymerization 2.30.30.40 63 33 87 2.19 2.51
1uhfA00 88.34 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 69 25 78 1.27 1.62
1gcqC00 88.22 Integrin-mediated signaling pathwayProto-oncogene vavProtein bindingMus musculusT cell differentiation 2.30.30.40 69 19 81 1.95 2.40
1ng2A01 88.12 Soluble fractionGTP bindingCellular defense responseSH3 domain bindingSuperoxide anion generation 2.30.30.40 44 20 76 1.43 1.86
1spkA00 87.05 Mus musculusBrain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 2.30.30.40 72 23 77 1.85 2.38
1j3tA00 86.59 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 74 30 72 1.14 1.56
2ke9A00 86.14 Caskin-2Homo sapiens 2.30.30.40 67 26 83 2.31 2.76
2epdA00 86.13 Rho protein signal transductionCytoskeleton organizationRho GTPase-activating protein 4Homo sapiensRho GTPase activator activity 2.30.30.40 76 32 72 1.32 1.82
2heqA01 85.64 Bacillus subtilisSPBc2 prophage-derived uncharacterized protein yorP 2.30.30.40 54 11 91 2.80 3.07
1sf9A02 85.34 Bacillus subtilisUncharacterized protein yfhH 2.30.30.340 54 9 75 1.32 1.76
1bb9A00 85.16 Rattus norvegicusProtein heterodimerization activityProtein C-terminus bindingSynaptic vesicle endocytosisMyc box-dependent-interacting protein 1 2.30.30.40 83 25 67 1.52 2.25
2g3rA01 84.87 CytoplasmHomo sapiensTumor suppressor p53-binding protein 1Protein binding 2.30.30.140 53 7 82 2.21 2.69
1igqB00 84.77 Escherichia coliTranscriptional repressor protein korB 2.30.30.150 57 10 71 1.70 2.36
1u3oA01 84.75 Rattus norvegicusVesicle-mediated transportProtein bindingAxonogenesisNeuron projection 2.30.30.40 62 17 87 2.21 2.54
3i5rA00 84.56 ErbB-3 class receptor bindingInsulin-like growth factor receptor signaling pathwayInsulin receptor signaling pathwayGrowth hormone receptor signaling pathwayInsulin-like growth factor receptor binding 2.30.30.40 81 35 69 2.07 2.99
1mmdA01 83.92 ActomyosinMyosin II complexActin-myosin filament slidingProtein localizationActin filament binding 2.30.30.360 48 8 82 3.67 4.47
1mhnA00 83.58 Survival motor neuron proteinSurvival motor neuron proteinHomo sapiensProtein binding 2.30.30.140 59 7 79 2.56 3.21
2rh2A00 83.15 Dihydrofolate reductase type 2Escherichia coli 2.30.30.60 57 14 77 2.05 2.66
1jxmA01 83.05 Postsynaptic membraneRattus norvegicusProtein C-terminus bindingIonotropic glutamate receptor bindingDisks large homolog 4 2.30.30.40 80 37 65 2.37 3.65
1dj7B00 82.14 Ferredoxin-thioredoxin reductase, variable chainProtein bindingSynechocystis sp. PCC 6803 2.30.30.50 73 7 76 3.79 4.94
1ug1A00 81.78 Dynamin-binding proteinHomo sapiensProtein binding 2.30.30.40 92 16 59 1.34 2.24
2vv5A02 81.18 Escherichia coli O157:H7Small conductance mechanosensitive ion channel, MscS familySmall-conductance mechanosensitive channel 2.30.30.60 50 14 71 2.39 3.35
1udlA00 81.04 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 98 32 56 1.40 2.49
1khcA01 80.98 Protein complex localizationRegulation of gene expression by genetic imprintingDNA (cytosine-5)-methyltransferase 3BChromosome, centromeric regionProtein binding 2.30.30.160 65 7 70 2.70 3.82
1i1jB00 80.87 Melanoma-derived growth regulatory proteinHomo sapiensExtracellular spaceCell proliferation 2.30.30.40 103 19 54 1.35 2.48
2aklA02 80.85 Phosphonate and phosphinate metabolismPseudomonas aeruginosaPhosphonoacetate hydrolase [EC:3.11.1.2]Putative uncharacterized protein 2.30.30.40 73 14 75 3.25 4.31
1biaA03 80.47 Biotin metabolismDNA bindingBirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Bifunctional protein birABiotin-[acetyl-CoA-carboxylase] ligase activity 2.30.30.100 47 10 78 2.78 3.54
1jb0E00 80.37 Photosystem I subunit IVPhotosynthesisThermosynechococcus elongatus BP-1Photosystem I reaction center subunit IVMetabolic pathways 2.30.30.50 69 5 69 2.32 3.33
1irxA02 80.33 Aminoacyl-tRNA biosynthesisLysyl-tRNA synthetase, class I [EC:6.1.1.6]Pyrococcus horikoshiiLysyl-tRNA synthetase 2.30.30.300 43 11 73 2.38 3.25
1ri9A00 80.13 FYN-binding proteinProtein phosphorylationNucleusHomo sapiensImmune response 2.30.30.40 77 17 72 2.31 3.18
2k57A00 80.01 Pseudomonas syringae pv. phaseolicola 1448ALipoprotein, putative 2.30.30.100 55 9 78 3.09 3.93
1uffA00 79.74 Intersectin-2Homo sapiensSH3/SH2 adaptor activity 2.30.30.40 93 30 59 1.60 2.71
2o2oA00 79.50 NucleusHomo sapiensSH3 domain-containing kinase-binding protein 1 2.30.30.40 75 26 73 2.33 3.18
1m9sA05 79.12 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 78 8 70 2.47 3.50
2ra2B00 78.79 Salmonella enterica subsp. enterica serovar TyphimuriumPutative lipoprotein 2.30.30.100 55 12 73 3.47 4.74
1ib8A02 78.68 Hypothetical proteinRibosome maturation factor rimPStreptococcus pneumoniae 2.30.30.180 67 16 73 2.84 3.88
1m9sA04 77.98 Internalin BListeria monocytogenesProtein bindingInternalin B 2.30.30.170 86 12 65 2.81 4.32
1awjA00 77.83 Mus musculusTyrosine-protein kinase ITK/TSKProtein binding 2.30.30.40 77 32 72 2.48 3.41
1uebA02 77.62 Thermus thermophilus HB8Elongation factor EF-PElongation factor P 2.40.50.140 63 7 57 2.62 4.58
1vytA01 77.47 Cardiac muscle contractionRattus norvegicusDilated cardiomyopathyVoltage-gated calcium channel complexCalcium channel, voltage-dependent, beta 3 subunit 2.30.30.40 108 26 51 1.60 3.09
2hqxA01 77.27 Staphylococcal nuclease domain-containing protein 1NucleusGolgi apparatusTranscription cofactor activityHomo sapiens 2.30.30.140 81 10 56 2.17 3.82
2awnB02 76.61 ABC transportersMaltooligosaccharide-importing ATPase activityMaltose/maltodextrin import ATP-binding protein MalKMaltose transportMaltose/maltodextrin transport system ATP-binding protein [EC:3.6.3.19] 2.40.50.100 66 5 53 2.01 3.79
2hjqA01 76.43 Uncharacterized protein yqbFBacillus subtilis 3.40.5.20 46 15 73 3.13 4.28
1kq1H00 76.07 RNA degradationHost factor-I proteinSimilar to host factor-1Staphylococcus aureus subsp. aureus Mu50 2.30.30.100 66 10 60 2.35 3.88
1u1sA00 75.68 RNA degradationPseudomonas aeruginosaHost factor-I proteinProtein hfq 2.30.30.100 66 3 62 2.54 4.09
1mgqF00 75.42 Methanothermobacter thermautotrophicus str. Delta HSmall nuclear ribonucleoproteinPutative snRNP Sm-like protein 2.30.30.100 70 5 62 3.12 4.96
1bi1A03 75.31 DtxR family transcriptional regulator, Mn-dependent transcriptional regulatorDiphtheria toxin repressorCorynebacterium diphtheriae 2.30.30.90 74 12 67 3.24 4.80
1d3bC00 75.15 SpliceosomeSystemic lupus erythematosusSmall nuclear ribonucleoprotein Sm D3Small nuclear ribonucleoprotein D3Spliceosomal complex 2.30.30.100 71 3 59 2.65 4.48
1pm3A00 74.90 Methanothermobacter thermautotrophicus str. Delta HPutative uncharacterized protein 2.30.30.240 69 10 59 2.47 4.16
1n9rB00 74.88 Protein bindingNuclear mRNA splicing, via spliceosomeSmall nuclear ribonucleoprotein FSmall nuclear ribonucleoprotein FU5 snRNP 2.30.30.100 69 7 62 2.71 4.35
3fb9B00 74.82 Streptococcus pneumoniaePutative uncharacterized protein 2.30.30.100 84 5 51 2.54 4.96
3f70B02 73.46 CytoplasmMethylated histone residue bindingLethal(3)malignant brain tumor-like protein 2Homo sapiens 2.30.30.160 88 0 51 2.39 4.67
3by7E00 72.98 2.30.30.100 74 7 55 2.73 4.93
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Displaying entries 1 to 72 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1ckaA00
AEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1ckaA00
AEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKY
BLAST against CATH

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Domain History Events (3)

Set cath from cathlist by auto on 05 Mar 2006 18:24

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:24

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 14:47

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"