CATH Domain: 1a7sA02 XML data for domain: 1a7sA02

Molscript image for 1a7sA02
1a7sA02
PDB coordinates for domain 1a7sA02

PDB 1a7s, Chain A, Domain 2

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.40 Beta Barrel
2.40.10 Thrombin, subunit H
2.40.10.10 Trypsin-like serine proteases Gene3D
2.40.10.10.14
2.40.10.10.14.1
2.40.10.10.14.1.1
2.40.10.10.14.1.1.1
2.40.10.10.14.1.1.1.1

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Segment boundaries for domain 1a7sA02

Chopping figure for domain 1a7sA02
DomainStart PDB ResidueStop PDB Residue
1a7sA01 1 12
1a7sA01 108 207
1a7sA02 13 107
1a7sA02 208 221

Structural Neighbourhood (34 entries)

There are 34 matching structural neighberhood comparisons for CATH ID 2.40.10.10.14.1.1.1.1 (SIMAX score < 5)

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Displaying entries 1 to 34 (page 1 of 1)
Match Depth Match SSAP score Match Keywords Match Superfamily Length Sequence Id Overlap RMSD SIMAX
1orfA02 93.06 Serine-type endopeptidase activityGranzyme A [EC:3.4.21.78]Protein homodimerization activityNucleusCleavage of lamin 2.40.10.10 105 32 97 1.46 1.50
1bioA02 92.68 Serine-type endopeptidase activityHomo sapiensComponent factor D [EC:3.4.21.46]Complement and coagulation cascadesComplement factor D 2.40.10.10 106 35 95 1.15 1.21
2jkhA02 92.40 Serine-type endopeptidase activityPositive regulation of cell migrationProtein bindingComplement and coagulation cascadesHomo sapiens 2.40.10.10 105 20 96 1.04 1.08
1nn6A02 92.38 ChymaseChymase [EC:3.4.21.39]Homo sapiensRenin-angiotensin systemInterleukin-1 beta biosynthetic process 2.40.10.10 107 33 95 1.85 1.94
2wphS02 91.68 Serine-type endopeptidase activityCoagulation factor IX (Christmas factor) [EC:3.4.21.22]Homo sapiensComplement and coagulation cascadesCoagulation factor IX 2.40.10.10 108 24 95 1.73 1.81
1ym0A02 91.50 Eisenia fetidaLumbrokinase F238 2.40.10.10 112 28 91 1.15 1.25
1gvzA02 90.94 Equus caballusKallikrein-1E2 2.40.10.10 115 30 89 1.37 1.53
2anyA02 90.43 Serine-type endopeptidase activityExtracellular spaceCytoplasmPlasminogen activationHomo sapiens 2.40.10.10 111 26 91 2.42 2.63
2r0lA02 90.31 Serine-type endopeptidase activityHomo sapiensHepatocyte growth factor activatorProtein bindingProteolysis 2.40.10.10 113 31 88 1.55 1.75
2asuB02 90.26 Hepatocyte growth factor-like proteinHomo sapiens 2.40.10.10 103 32 90 1.52 1.68
1fiwA02 89.22 Ovis ariesAcrosinDrug binding 2.40.10.10 120 20 86 2.18 2.52
2hlcA01 89.01 CollagenaseHypoderma lineatum 2.40.10.10 104 22 92 3.11 3.37
1elvA01 89.01 Serine-type endopeptidase activitySystemic lupus erythematosusComplement C1s subcomponentHomo sapiensComplement component 1, s subcomponent [EC:3.4.21.42] 2.40.10.10 98 21 83 1.60 1.91
3govB02 89.00 Serine-type endopeptidase activityCalcium ion bindingProtein homodimerization activityExtracellular spaceProtein binding 2.40.10.10 123 27 83 1.96 2.34
1p57B02 88.94 Serine protease hepsinIntegral to plasma membraneHepsin (transmembrane protease, serine 1) [EC:3.4.21.-]Homo sapiens 2.40.10.10 118 27 86 1.68 1.94
1gj7B02 88.88 Regulation of smooth muscle cell migrationCell surfaceUrokinase-type plasminogen activatorProteolysisExtracellular space 2.40.10.10 118 25 85 1.59 1.86
1q3xA03 88.67 Serine-type endopeptidase activityHomo sapiensMannan-binding lectin serine protease 2Calcium-dependent protein bindingComplement activation, lectin pathway 2.40.10.10 100 19 87 1.67 1.91
2aiqA02 88.60 Agkistrodon contortrix contortrixAncrod 2.40.10.10 113 23 90 2.19 2.43
3beuA02 88.07 Streptomyces griseusTrypsin 2.40.10.10 99 24 88 1.99 2.25
1p3cA02 85.41 Glutamyl-endopeptidaseBacillus intermedius 2.40.10.10 107 17 88 2.47 2.78
1rrkA02 84.83 Complement factor BComplement bindingHomo sapiensComponent factor B [EC:3.4.21.47]Complement and coagulation cascades 2.40.10.10 117 19 70 2.81 3.96
1agjA02 83.80 Exfoliative toxin AStaphylococcus aureus 2.40.10.10 108 12 84 2.51 2.98
2pkaA00 83.76 Sus scrofaGlandular kallikrein 2.40.10.10 80 22 64 1.39 2.15
2o8lA02 82.72 Glutamyl endopeptidase [EC:3.4.21.19]Glutamyl endopeptidaseStaphylococcus aureus subsp. aureus Mu50 2.40.10.10 101 8 78 3.04 3.89
1ky9A01 81.61 Two-component systemSerine-type endopeptidase activityProtease doResponse to temperature stimulusProtein binding 2.40.10.10 88 21 76 3.30 4.33
2qf3A01 79.94 Protease degSProtein bindingSerine protease DegS [EC:3.4.21.-]Escherichia coli K-12 2.40.10.10 102 12 68 3.13 4.56
1lcyA01 79.63 Serine-type endopeptidase activityHtrA serine peptidase 2 [EC:3.4.21.108]Parkinson's diseaseEndoplasmic reticulum membraneNucleus 2.40.10.10 111 12 70 2.76 3.93
1sotA01 79.07 Escherichia coli O157:H7Protease degSSerine protease DegS [EC:3.4.21.-] 2.40.10.10 118 13 71 3.29 4.62
2z9iC01 78.72 Two-component systemPutative serine protease PepD [EC:3.4.21.-]PROBABLE SERINE PROTEASE PEPD (SERINE PROTEINASE) (MTB32B)Mycobacterium tuberculosis 2.40.10.10 91 10 65 2.26 3.44
1lvmA02 78.35 Genome polyproteinTobacco etch virus 2.40.10.10 106 10 76 3.59 4.70
2halA01 78.09 Human hepatitis A virus Hu/Australia/HM175/1976Genome polyprotein 2.40.10.10 109 7 75 3.00 3.99
2hntC00 74.56 Serine-type endopeptidase activityFibrinolysisProthrombinSoluble fractionPositive regulation of protein phosphorylation 2.40.10.10 67 19 40 0.99 2.42
1befA02 72.78 2.40.10.10 85 2 60 3.04 4.99
1eptA00 69.90 Sus scrofaTrypsin 2.40.10.10 43 30 29 0.53 1.80
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Displaying entries 1 to 34 (page 1 of 1)


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Domain ATOM Sequence 

>pdb|1a7sA02
PFLASIQNQGRHFCGGALIHARFVMTAASCFPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLD
REANLTSSVTILFRDWIDGVLNNPG
BLAST against CATH

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Domain COMBS Sequence 

>pdb|1a7sA02
PFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLML
LQLDREANLTSSVTILFRDWIDGVLNNPG
BLAST against CATH

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Domain History Events (4)

Update comment by auto on 16 Oct 2007 19:44

Around September/October 2007, this domain was renamed from "1a7s002" to "1a7sA02" as part of the work to deal with the remediation of the PDB (see http://remediation.wwpdb.org). Please see ticket:207 or wiki:Remediation on the CATH Trac system for more details.

Set cath from cathlist by auto on 05 Mar 2006 18:27

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Flow stage update by auto on 05 Mar 2006 18:27

This domain was assigned by cathlist2DB and was parsed from the cath list "/usr/local/cvs/source/lists/CathList"

Insertion by auto on 05 Mar 2006 16:06

PDB chopped based on information from the domall file "/usr/local/cvs/source/lists/CathDomall"