CATH Classification

Domain Context

CATH Clusters

Superfamily Alpha carbonic anhydrase
Functional Family Carbonic anhydrase 2

Enzyme Information

4.2.1.1
Carbonic anhydrase.
based on mapping to UniProt P00918
H(2)CO(3) = CO(2) + H(2)O.
-!- The enzyme catalyzes the reversible hydration of gaseous CO(2) to carbonic acid, which spontaneously converts to hydrogencarbonate under neutral pH. -!- It is widespread and found in archaea, bacteria, and eukaryotes. -!- Three distinct classes exist, and appear to have evolved independently.

UniProtKB Entries (1)

P00918
CAH2_HUMAN
Homo sapiens
Carbonic anhydrase 2

PDB Structure

PDB 12CA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121.
Nair, S.K., Calderone, T.L., Christianson, D.W., Fierke, C.A.
J.Biol.Chem.