Homologous Superfamily: 2.30.29.30

Molscript image for 1unqA00
Representative domain: 1unqA00
PDB coordinates for domain 1unqA00

Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)

Classification Lineage (2.30.29.30)

CATH CodeLevel DescriptionLinks
2 Mainly Beta
2.30 Roll
2.30.29 PH-domain like
2.30.29.30 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) Gene3D

Summary of Non-Redundant Representatives
- - - - 49 57 78 114 249

S35 Family Entries in Homologous Superfamily 2.30.29.30 (49)

CATH Level CATH code Representative Domain Representative Keywords Representative Thumbnail Number of Domains
2.30.29.30.1 1unqA00 Jak-STAT signaling pathwayNeurotrophin signaling pathwayResponse to heatPositive regulation of cyclin-dependent protein kinase activity involved in G1/SInsulin-like growth factor receptor signaling pathway Molscript image for 1unqA00 16
2.30.29.30.2 1xodB00 Jak-STAT signaling pathwaySprouty-related, EVH1 domain containingXenopus (Silurana) tropicalisSprouty-related, EVH1 domain-containing protein 1 Molscript image for 1xodB00 4
2.30.29.30.3 1fgyA00 CytoplasmPositive regulation of cell adhesionRuffleMus musculusPhosphatidylinositol-3,4,5-trisphosphate binding Molscript image for 1fgyA00 9
2.30.29.30.4 1upqA00 Pleckstrin homology domain-containing family A member 4Homo sapiens Molscript image for 1upqA00 3
2.30.29.30.5 1eazA00 NucleusPleckstrin homology domain-containing family A member 1B cell receptor signaling pathwayPhosphatidylinositol-3,4-bisphosphate bindingRuffle organization Molscript image for 1eazA00 1
2.30.29.30.6 3f5rA00 DNA-dependent DNA replicationPositive regulation of RNA polymerase II transcriptional preinitiation complex assemblyDNA replication-independent nucleosome organizationProtein bindingFACT complex subunit POB3 Molscript image for 3f5rA00 1
2.30.29.30.7 2p8vA00 Homer protein homolog 3Metabotropic glutamate receptor signaling pathwayProtein targetingHomo sapiensProtein binding Molscript image for 2p8vA00 6
2.30.29.30.8 1ntyA02 Non-specific serine/threonine protein kinase.Triple functional domain protein [EC:2.7.11.-]Triple functional domain proteinHomo sapiensProtein serine/threonine kinase activity Molscript image for 1ntyA02 2
2.30.29.30.9 2i5fA00 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRuffle organization Molscript image for 2i5fA00 9
2.30.29.30.10 1maiA00 Calcium ion bindingCalcium signaling pathwayPhosphatidylinositol signaling systemRattus norvegicusElevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger Molscript image for 1maiA00 1
2.30.29.30.11 1ddwA00 DendriteRattus norvegicusType 5 metabotropic glutamate receptor bindingResponse to cocaineResponse to stress Molscript image for 1ddwA00 2
2.30.29.30.12 1u5dA00 Positive regulation of transcription from RNA polymerase II promoterPlasma membraneT cell receptor signaling pathwayAntigen bindingCytoplasm Molscript image for 1u5dA00 11
2.30.29.30.13 1evhA00 LamellipodiumFocal adhesionSH3 domain bindingStress fiberActin polymerization or depolymerization Molscript image for 1evhA00 8
2.30.29.30.14 1w1hD00 Non-specific serine/threonine protein kinase.PPAR signaling pathway3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]Peptidyl-threonine phosphorylationAldosterone-regulated sodium reabsorption Molscript image for 1w1hD00 7
2.30.29.30.15 1txdA02 Rho guanine nucleotide exchange factor 12Homo sapiensRegulation of actin cytoskeletonG-protein-coupled receptor bindingG-protein coupled receptor protein signaling pathway Molscript image for 1txdA02 4
2.30.29.30.16 1zsqA01 Nucleus[EC:3.1.3.-]Fructose and mannose metabolismMetabolic pathwaysRiboflavin metabolism Molscript image for 1zsqA01 5
2.30.29.30.17 1faoA00 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePhosphatidylinositol-3,4,5-trisphosphate bindingDual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositidePlasma membraneHomo sapiens Molscript image for 1faoA00 2
2.30.29.30.18 1btnA00 Spectrin beta chain, brain 1SMAD protein import into nucleusMus musculusCuticular platePlasma membrane Molscript image for 1btnA00 4
2.30.29.30.19 1dynA00 Dynamin GTPase.GTPase activityReceptor-mediated endocytosisHomo sapiensDynamin-1 Molscript image for 1dynA00 5
2.30.29.30.20 1aqcB00 Nervous system developmentSynaptic transmissionCell adhesionAmyloid beta (A4) precursor protein-binding, family A, member 1 (X11)Axon cargo transport Molscript image for 1aqcB00 4
2.30.29.30.21 1mixA02 Talin-1Focal adhesionFocal adhesionGallus gallusTalin Molscript image for 1mixA02 16
2.30.29.30.22 1ntvA00 Radial glia guided migration of Purkinje cellDisabled homolog 1Negative regulation of cell adhesionCell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migrationMus musculus Molscript image for 1ntvA00 10
2.30.29.30.23 1dbhA02 Jak-STAT signaling pathwayPathways in cancerChemokine signaling pathwayNeurotrophin signaling pathwayB cell receptor signaling pathway Molscript image for 1dbhA02 5
2.30.29.30.24 1ef1A03 Leukocyte migrationReceptor bindingCytoskeletonMembrane to membrane dockingNucleolus Molscript image for 1ef1A03 29
2.30.29.30.25 2he7A03 Tight junctionHomo sapiensErythrocyte membrane protein band 4.1Cell-cell junctionBand 4.1-like protein 3 Molscript image for 2he7A03 5
2.30.29.30.26 1qqgA02 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayNegative regulation of insulin secretionInsulin-like growth factor receptor signaling pathway Molscript image for 1qqgA02 3
2.30.29.30.27 1p5tA00 Mus musculusRas protein signal transductionDocking protein 1Transmembrane receptor protein tyrosine kinase signaling pathwayTransmembrane receptor protein tyrosine kinase signaling protein activity Molscript image for 1p5tA00 6
2.30.29.30.28 1qqgA01 Phosphoinositide 3-kinase bindingAldosterone-regulated sodium reabsorptionNeurotrophin signaling pathwayInsulin-like growth factor receptor signaling pathwayNegative regulation of insulin secretion Molscript image for 1qqgA01 2
2.30.29.30.29 1btkA00 Phosphatidylinositol-3,4,5-trisphosphate bindingBruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]B cell receptor signaling pathwayCytosolCalcium-mediated signaling Molscript image for 1btkA00 10
2.30.29.30.30 1kz7C02 Mus musculusGuanine nucleotide exchange factor DBSRho guanyl-nucleotide exchange factor activityRho protein signal transductionLamellipodium Molscript image for 1kz7C02 12
2.30.29.30.31 1q67A01 MRNA-decapping enzyme subunit 1Cytoplasmic mRNA processing bodyRNA degradationEnzyme activator activityMRNA binding Molscript image for 1q67A01 2
2.30.29.30.32 1omwA05 MembraneG-protein coupled receptor kinase activityNegative regulation of the force of heart contraction by chemical signalChemokine signaling pathwayMuscarinic acetylcholine receptor signaling pathway Molscript image for 1omwA05 6
2.30.29.30.33 1ki1B02 Synaptic vesicle endocytosisHomo sapiensProtein bindingIntersectin-1 Molscript image for 1ki1B02 2
2.30.29.30.34 3cxbB00 Kinesin bindingGolgi organizationPleckstrin homology domain-containing family M member 2Homo sapiens Molscript image for 3cxbB00 2
2.30.29.30.35 1rrpB00 Ran GTPase bindingNuclear poreProtein import into nucleusE3 SUMO-protein ligase RanBP2Homo sapiens Molscript image for 1rrpB00 11
2.30.29.30.36 2rgnB02 Homo sapiensGuanine nucleotide exchange factor GEFT Molscript image for 2rgnB02 2
2.30.29.30.37 1foeC02 Mus musculusPositive regulation of axonogenesisT-lymphoma invasion and metastasis-inducing protein 1Plasma membraneSmall GTPase mediated signal transduction Molscript image for 1foeC02 4
2.30.29.30.38 1v89A00 Homo sapiensRho GTPase-activating protein 25 Molscript image for 1v89A00 1
2.30.29.30.39 2coaA01 Homo sapiensSerine/threonine-protein kinase D2Protein kinase C. Molscript image for 2coaA01 2
2.30.29.30.40 1fhoA00 Caenorhabditis elegansMuscle M-line assembly protein unc-89Locomotion Molscript image for 1fhoA00 1
2.30.29.30.41 2dn6A00 CytoplasmPlasma membraneSwitch-associated protein 70Homo sapiens Molscript image for 2dn6A00 1
2.30.29.30.42 1plsA00 Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRuffle organization Molscript image for 1plsA00 1
2.30.29.30.43 2dhjA00 Rho GTPase-activating protein 21Homo sapiens Molscript image for 2dhjA00 1
2.30.29.30.44 1pfjA00 Positive regulation of transcription from RNA polymerase II promoterGeneral transcription factor IIH subunit 1Nucleotide excision repairGeneral RNA polymerase II transcription factor activityTranscription initiation factor TFIIH subunit H1 Molscript image for 1pfjA00 2
2.30.29.30.45 1v88A00 Oxysterol-binding protein-related protein 8Homo sapiens Molscript image for 1v88A00 1
2.30.29.30.46 1ddmA00 Sensory organ precursor cell fate determinationSensory organ precursor cell divisionProtein localizationNotch signaling pathwayDrosophila melanogaster Molscript image for 1ddmA00 3
2.30.29.30.47 1mkeA00 Rattus norvegicusNeural Wiskott-Aldrich syndrome protein Molscript image for 1mkeA00 1
2.30.29.30.48 1xr0B01 Fibroblast growth factor receptor substrate 2Membrane fractionTransmembrane receptor protein tyrosine kinase adaptor activityIntegral to plasma membraneNeurotrophin signaling pathway Molscript image for 1xr0B01 1
2.30.29.30.49 1oy2A00 SHC-transforming protein 1Transmembrane receptor protein tyrosine kinase adaptor activityRegulation of epidermal growth factor receptor activityEpidermal growth factor receptor signaling pathwayInsulin-like growth factor receptor binding Molscript image for 1oy2A00 3

Close Structural Clusters 2.30.29.30 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00002.00030.00029.00030/SSG5/1 1ntvA00 3
00002.00030.00029.00030/SSG5/2 1ntyA02 3
00002.00030.00029.00030/SSG5/3 1qqgA02 3
00002.00030.00029.00030/SSG5/4 2dhjA00 2
00002.00030.00029.00030/SSG5/5 1fgyA00 4
00002.00030.00029.00030/SSG5/6 2dn6A00 13
00002.00030.00029.00030/SSG5/7 1txdA02 5
00002.00030.00029.00030/SSG5/8 1evhA00 5
00002.00030.00029.00030/SSG5/9 2i5fA00 4
00002.00030.00029.00030/SSG5/10 1q67A01 2


Distant Structural Clusters 2.30.29.30 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID Example Domain Domains in Cluster Structural Alignment (Core) Structural Alignment (Expanded)
00002.00030.00029.00030/SSGA9/1 1aqcB00 11
00002.00030.00029.00030/SSGA9/2 1fhoA00 2
00002.00030.00029.00030/SSGA9/3 1mkeA00 2


Structural Comparisons for Non-redundant S35 Representatives of 2.30.29.30 ( entries)