Homologous Superfamily: 1.10.10.10

Representative domain: 1i27A00

"winged helix" repressor DNA binding domain

Classification Lineage (1.10.10.10)

CATH Code	Level Description	Links
1	Mainly Alpha
1.10	Orthogonal Bundle
1.10.10	Arc Repressor Mutant, subunit A
1.10.10.10	"winged helix" repressor DNA binding domain	Gene3D

Summary of Non-Redundant Representatives


-	-	-	-	217	254	286	466	1052

Non-Redundant Representatives (217)
Alignments (67)
Structural Neighbours ()
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S35 Family Entries in Homologous Superfamily 1.10.10.10 (217)

CATH code	Representative Domain	Representative Keywords	Number of Domains
1.10.10.10.1	1i27A00	General RNA polymerase II transcription factor activityTranscription initiation factor TFIIF alpha subunitTranscription coactivator activityTranscription factor TFIIF complexBasal transcription factors	5
1.10.10.10.2	1ucrB00	Desulfovibrio vulgaris str. HildenboroughProtein dsvD	4
1.10.10.10.3	1y0uB00	Arsenical resistance operon repressor, putativeArchaeoglobus fulgidus	2
1.10.10.10.4	1b6aA02	N-terminal protein amino acid modificationMethionine aminopeptidase 2Peptidyl-methionine modificationCytoplasmProtein processing	14
1.10.10.10.5	1r7jA00	Sulfolobus solfataricusDNA-binding protein	3
1.10.10.10.6	1dp7P00	Regulatory factor X 1/2/3Sequence-specific enhancer binding RNA polymerase II transcription factor activityImmune responseHomo sapiensMHC class II regulatory factor RFX1	1
1.10.10.10.7	3htsB00	Heat shock factor proteinKluyveromyces lactis	15
1.10.10.10.8	2obpA00	Ralstonia eutropha JMP134Putative DNA-binding protein	2
1.10.10.10.9	1hw1A01	Fatty acid metabolism regulator proteinEscherichia coli K-12GntR family transcriptional regulator, negative regulator for fad regulon and positive regulator of fabA	8
1.10.10.10.10	2vooB01	TRNA modificationNucleolusMRNA bindingProtein bindingLupus La protein	13
1.10.10.10.11	1mgtA02	Methylated-DNA--[protein]-cysteine S-methyltransferase.Thermococcus kodakarensisMethylated-DNA--protein-cysteine methyltransferaseMethylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	11
1.10.10.10.12	1fp2A01	Isoflavone 7-O-methyltransferase.Medicago sativaIsoflavone-7-O-methyltransferase 8	8
1.10.10.10.13	2gauA02	Transcriptional regulator, Crp/Fnr familyPorphyromonas gingivalis	1
1.10.10.10.14	1xgsA02	Pyrococcus furiosusMethionyl aminopeptidase [EC:3.4.11.18]Methionine aminopeptidaseMethionyl aminopeptidase.	9
1.10.10.10.15	1in4A02	Thermotoga maritimaHolliday junction DNA helicase RuvBHomologous recombinationIn phosphorous-containing anhydrides.Holliday junction ATP-dependent DNA helicase ruvB	10
1.10.10.10.16	1wrjA02	Methylated-DNA--[protein]-cysteine S-methyltransferase.Methylated-DNA--protein-cysteine methyltransferaseSulfolobus tokodaiiMethylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]	2
1.10.10.10.17	2ns0A00	Rhodococcus jostii RHA1Putative uncharacterized protein	1
1.10.10.10.18	3f6vA00	Possible transcriptional regulator, ArsR family proteinRhodococcus jostii RHA1	1
1.10.10.10.19	2qvoA00	Archaeoglobus fulgidusUncharacterized protein AF_1382	1
1.10.10.10.20	1t6sB01	Chlorobaculum tepidumSegregation and condensation protein BSegregation and condensation protein B	2
1.10.10.10.21	2od5A00		1
1.10.10.10.22	2rkhA01		1
1.10.10.10.23	1on2A01	Bacillus subtilisTranscriptional regulator mntR	22
1.10.10.10.24	2o3fA00	Bacillus subtilisUncharacterized HTH-type transcriptional regulator ybbH	3
1.10.10.10.25	1kgsA02	Thermotoga maritimaResponse regulatorTwo-component system, OmpR family, response regulator	1
1.10.10.10.26	2qm3A01	Pyrococcus furiosusPutative uncharacterized protein	1
1.10.10.10.27	2f2eA01	Pseudomonas aeruginosaPutative uncharacterized protein	2
1.10.10.10.28	2p8tA01	Pyrococcus horikoshiiPutative uncharacterized protein PH0730	1
1.10.10.10.29	1t6sB02	Chlorobaculum tepidumSegregation and condensation protein BSegregation and condensation protein B	2
1.10.10.10.30	1yo5C00	SAM pointed domain-containing ETS transcription factorHomo sapiensSAM pointed domain-containing Ets transcription factorProtein bindingMulticellular organismal development	6
1.10.10.10.31	2hztC00	Bacillus subtilisUncharacterized HTH-type transcriptional regulator ytcD	6
1.10.10.10.32	3jthB00	Transcription activator HlyUVibrio vulnificus	6
1.10.10.10.33	1duxC00	Positive regulation of transcription from RNA polymerase II promoterPrion diseasesInsulin signaling pathwayEndometrial cancerProtein binding	8
1.10.10.10.34	3f6oB00	Rhodococcus jostii RHA1Probable transcriptional regulator, ArsR family protein	2
1.10.10.10.35	3ctaA01	Riboflavin metabolismCTP-dependent riboflavin kinase.Riboflavin kinaseRiboflavin kinase, archaea type [EC:2.7.1.161]Thermoplasma acidophilum	1
1.10.10.10.36	3b73A00	PhiH1 repressor-likeHaloarcula marismortui	2
1.10.10.10.37	1p2fA02	Thermotoga maritimaResponse regulatorTwo-component system, OmpR family, response regulator	1
1.10.10.10.38	1stzA01	Heat-inducible transcription repressor hrcAThermotoga maritimaHeat-inducible transcriptional repressor	3
1.10.10.10.39	3h92A00	Methanocaldococcus jannaschiiUncharacterized ATP-binding protein MJECL15	2
1.10.10.10.40	3jtgA01	Mus musculusE74-like factor 3/5ETS-related transcription factor Elf-3Sequence-specific DNA binding transcription factor activityEmbryo development	2
1.10.10.10.41	3fm3A02	Methionine aminopeptidase 2Methionyl aminopeptidase [EC:3.4.11.18]Encephalitozoon cuniculiMethionyl aminopeptidase.	12
1.10.10.10.42	1pueE00	Lymphoid progenitor cell differentiationPathways in cancerMyeloid dendritic cell differentiationErythrocyte differentiationAcute myeloid leukemia	2
1.10.10.10.43	1rz4A02	Eukaryotic translation initiation factor 3 subunit KTranslational initiationEukaryotic translation initiation factor 3 complexHomo sapiensProtein binding	1
1.10.10.10.44	1r1tA00	Transcriptional repressor smtBSynechococcus elongatus PCC 7942	10
1.10.10.10.45	1a04A02	Two-component system, NarL family, nitrate/nitrite response regulator NarLTwo-component systemProtein bindingNitrate/nitrite response regulator protein narLEscherichia coli K-12	3
1.10.10.10.46	1b9mB01	Transcriptional regulator modEMolybdate transport system regulatory proteinEscherichia coli K-12	8
1.10.10.10.47	1sfxB00	Archaeoglobus fulgidusPutative uncharacterized protein	2
1.10.10.10.48	1hsjA03	Staphylococcus aureus subsp. aureus NCTC 8325HTH-type transcriptional regulator sarR	2
1.10.10.10.49	2fokA02	Type II site-specific deoxyribonuclease.Planomicrobium okeanokoitesType-2 restriction enzyme FokI	3
1.10.10.10.50	2r3sB01		2
1.10.10.10.51	2esnA01	Probable transcriptional regulatorPseudomonas aeruginosa	4
1.10.10.10.52	3c7jA01	Pseudomonas syringae pv. syringaeRegulatory protein GntR	2
1.10.10.10.53	3elkB00	Putative uncharacterized protein Ta0346Thermoplasma acidophilum	2
1.10.10.10.54	1ixcA01	LysR-type regulatory proteinCupriavidus necator	6
1.10.10.10.55	1yg2A01	Vibrio choleraeVibrio cholerae pathogenic cyclePadR family transcriptional regulator, regulatory protein AphAPutative uncharacterized protein	1
1.10.10.10.56	1lddA00	Mitotic sister chromatid segregationProtein ubiquitinationCyclin catabolic processAnaphase-promoting complex subunit 2Meiosis - yeast	4
1.10.10.10.57	1jhfA02	Repressor LexA [EC:3.4.21.88]LexA repressorProtein bindingEscherichia coli K-12Transcription	4
1.10.10.10.58	2r7dA01	Exoribonuclease II [EC:3.1.13.1]Ribonuclease II family proteinDeinococcus radiodurans	4
1.10.10.10.59	2dtrA01	DtxR family transcriptional regulator, Mn-dependent transcriptional regulatorDiphtheria toxin repressorCorynebacterium diphtheriae	46
1.10.10.10.60	2o0yC01	Rhodococcus jostii RHA1Transcriptional regulator	2
1.10.10.10.61	3edpA01	Listeria innocuaLin2111 protein	2
1.10.10.10.62	3i53B01	O-methyltransferaseStreptomyces carzinostaticus subsp. neocarzinostaticus	17
1.10.10.10.63	1r1uB00	CzrA proteinStaphylococcus aureus	10
1.10.10.10.64	3bz6A01	Hypothetical proteinPseudomonas syringae pv. tomatoUPF0502 protein PSPTO_2686	2
1.10.10.10.65	1hw5A02	TranscriptionTranscription activator activityTranscription repressor activityProtein bindingCatabolite gene activator	49
1.10.10.10.66	2oqgC00	Possible transcriptional regulator, ArsR family proteinRhodococcus jostii RHA1	4
1.10.10.10.67	3by6C01	GntR family transcriptional regulatorOenococcus oeni PSU-1Transcriptional regulator, GntR family	5
1.10.10.10.68	1z05A01	Vibrio choleraeTranscriptional regulator, ROK family	1
1.10.10.10.69	2fnaA03	Sulfolobus solfataricusPutative uncharacterized protein	2
1.10.10.10.70	1mkmB01	Thermotoga maritimaTranscriptional regulator, IclR family	4
1.10.10.10.71	1d3yA01	DNA topoisomerase VI subunit A [EC:5.99.1.3]Methanocaldococcus jannaschiiDNA topoisomerase (ATP-hydrolyzing).Type II DNA topoisomerase VI subunit A	2
1.10.10.10.72	2ga1A02	Anabaena variabilis ATCC 29413Putative uncharacterized protein	2
1.10.10.10.73	1s8nA02	Response regulator NasTProbable transcriptional regulatory protein pdtaRMycobacterium tuberculosis	2
1.10.10.10.74	3bz6A02	Hypothetical proteinPseudomonas syringae pv. tomatoUPF0502 protein PSPTO_2686	2
1.10.10.10.75	2pg4A00	Aeropyrum pernixPutative uncharacterized protein	2
1.10.10.10.76	1t0fA02	Transposition, DNA-mediatedTransposase activityEscherichia coliCytoplasmic chromosomeTransposon Tn7 transposition protein tnsA	4
1.10.10.10.77	1sfuA00	Yaba-like disease virus34L protein	2
1.10.10.10.78	1l3lA02	Transcriptional activator protein traRAgrobacterium tumefaciens	8
1.10.10.10.79	3df8A00	Thermoplasma volcanium GSS1Putative uncharacterized protein TVG1336486	1
1.10.10.10.80	2bgcH02	Listeria monocytogenesListeriolysin regulatory protein	12
1.10.10.10.81	1xsvA00	Hypothetical proteinUPF0122 protein SAV1236Staphylococcus aureus subsp. aureus Mu50	5
1.10.10.10.82	2dt5B01	Thermus thermophilus HB8Redox-sensing transcriptional repressor rexAT-rich DNA-binding protein	22
1.10.10.10.83	1fseB00	Bacillus subtilisLuxR family transcriptional regulator, transcriptional regulator of spore coat proteinSpore germination protein gerE	16
1.10.10.10.84	2fb1A02	Bacteroides thetaiotaomicronNUDIX family hydrolase	4
1.10.10.10.85	1opcA00	Two-component systemTwo-component system, OmpR family, phosphate regulon response regulator OmpRTranscriptional regulatory protein ompRProtein bindingEscherichia coli K-12	3
1.10.10.10.86	1ulyA01	Pyrococcus horikoshiiPutative uncharacterized protein PH1932	2
1.10.10.10.87	1cf7B00	Protein domain specific bindingTranscription factor Dp-2Transcription cofactor activityHomo sapiens	1
1.10.10.10.88	1o57A01	Pur operon repressorBacillus subtilisPurine operon repressor	12
1.10.10.10.89	2g7uA01	Rhodococcus opacusPutative regulator of catechol degradative operon	6
1.10.10.10.90	2heoA00	Mus musculusLeft-handed Z-DNA bindingZ-DNA-binding protein 1	3
1.10.10.10.91	1lvaA02	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1
1.10.10.10.92	1bjaA00	Transcription regulatory protein motAEnterobacteria phage T4	3
1.10.10.10.93	1ku3A00	RNA polymerase sigma factorThermus aquaticus	9
1.10.10.10.94	2pn6A01	150aa long hypothetical transcriptional regulatorSulfolobus tokodaii	29
1.10.10.10.95	3cuqA02	Transcription factor bindingTranscription factor complexRNA polymerase II transcription factor activityEndocytosisESCRT-II complex subunit VPS22	4
1.10.10.10.96	3bwgB01	Uncharacterized HTH-type transcriptional regulator yydKGntR family transcriptional regulator, transcriptional regulator of bglABacillus subtilis	3
1.10.10.10.97	1fp1D01	Methyltransferases.Medicago sativaIsoliquiritigenin 2'-O-methyltransferase	7
1.10.10.10.98	3cuqA03	Transcription factor bindingTranscription factor complexRNA polymerase II transcription factor activityEndocytosisESCRT-II complex subunit VPS22	4
1.10.10.10.99	1fc3B00	Geobacillus stearothermophilusStage 0 sporulation protein A	7
1.10.10.10.100	1ub9A00	Pyrococcus horikoshiiPutative uncharacterized protein PH1061	1
1.10.10.10.101	1ft9A02	Rhodospirillum rubrumCooA protein	2
1.10.10.10.102	2o0yB01	Rhodococcus jostii RHA1Transcriptional regulator	2
1.10.10.10.103	1qbjC00	CytoplasmNucleolusHomo sapiensDouble-stranded RNA-specific adenosine deaminaseIn cyclic amidines.	27
1.10.10.10.104	1ku9A01	DNA-binding protein MJ1563Methanocaldococcus jannaschii	2
1.10.10.10.105	2fswA00	Porphyromonas gingivalisPutative uncharacterized protein	2
1.10.10.10.106	1fnnB03	Pyrobaculum aerophilumCell division control protein 6 (Cdc6), putativeArchaeal cell division control protein 6	2
1.10.10.10.107	2hs5A01	Rhodococcus jostii RHA1Probable transcriptional regulator, GntR family protein	1
1.10.10.10.108	3cloA02	Bacteroides thetaiotaomicronTranscriptional regulator	4
1.10.10.10.109	2pi0A01	Interferon regulatory factor 3Interferon regulatory factor 3RNA polymerase II transcription factor activityTranscription from RNA polymerase II promoterRIG-I-like receptor signaling pathway	10
1.10.10.10.110	3fxrA01	LysR type regulator of tsaMBCDComamonas testosteroni	1
1.10.10.10.111	2ia1B02	BH3703 proteinBacillus halodurans	4
1.10.10.10.112	1je8E00	Escherichia coli O157:H7Two-component system, NarL family, nitrate/nitrite response regulator NarLTwo-component systemNitrate/nitrite response regulator protein narL	12
1.10.10.10.113	1gxqA00	Phosphate regulon transcriptional regulatory protein phoBTwo-component systemTwo-component system, OmpR family, phosphate regulon response regulator PhoBProtein bindingEscherichia coli K-12	7
1.10.10.10.114	3dfgA01	Xanthomonas campestris pv. campestrisRegulatory proteinRegulatory protein recX	1
1.10.10.10.115	3dfgA03	Xanthomonas campestris pv. campestrisRegulatory proteinRegulatory protein recX	1
1.10.10.10.116	1repC02	Escherichia coli K-12Replication initiation protein	1
1.10.10.10.117	1k78A01	Transcription from RNA polymerase II promoterPaired box protein Pax-5Organ morphogenesisPaired box protein 2/5Humoral immune response	5
1.10.10.10.118	2c6yB00	Regulation of transcription from RNA polymerase II promoterSequence-specific DNA bindingMagnesium ion bindingForkhead box protein KRNA polymerase II transcription factor activity	5
1.10.10.10.119	1tbxB00	Sulfolobus virus 1Protein F-93	2
1.10.10.10.120	1hstA00	Histone H1/5Gallus gallusHistone H5	3
1.10.10.10.121	1lvaA03	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	4
1.10.10.10.122	3dfgA02	Xanthomonas campestris pv. campestrisRegulatory proteinRegulatory protein recX	1
1.10.10.10.123	3fzvB01	Probable transcriptional regulatorPseudomonas aeruginosa	4
1.10.10.10.124	1q1hA00	Sulfolobus solfataricusTranscription initiation factor TFIIE alpha subunitTranscription factor EBasal transcription factors	1
1.10.10.10.125	2ia2C01	Rhodococcus sp. DK17PcaR	1
1.10.10.10.126	1k78B00	Protein C-ets-1Positive regulation of transcription from RNA polymerase II promoterMus musculusTranscription factor complexProtein binding	11
1.10.10.10.127	3c18A03	Exiguobacterium sibiricum 255-15Putative uncharacterized protein	3
1.10.10.10.128	1lvaA04	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	5
1.10.10.10.129	1biaA01	BirA family transcriptional regulator, biotin operon repressor / biotin-[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]Biotin biosynthetic processProtein bindingEscherichia coli K-12Biotin metabolism	6
1.10.10.10.130	1j5yA01	Thermotoga maritimaTranscriptional regulator, biotin repressor family	1
1.10.10.10.131	1lvaA01	Selenocysteine-specific elongation factorSelenocysteine-specific elongation factorMoorella thermoacetica	1
1.10.10.10.132	1s3jA02	Bacillus subtilisUncharacterized HTH-type transcriptional regulator yusO	2
1.10.10.10.133	2fmlB03	MutT/nudix family proteinEnterococcus faecalis	2
1.10.10.10.134	1ldkB03	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	2
1.10.10.10.135	2ijlB00	Agrobacterium tumefaciens str. C58Molybdenum-binding transcriptional repressorMolybdate transport system regulatory protein	2
1.10.10.10.136	2dbbB01	Pyrococcus horikoshiiUncharacterized HTH-type transcriptional regulator PH0061	2
1.10.10.10.137	2ia2D01	Rhodococcus sp. DK17PcaR	1
1.10.10.10.138	1yioA02	Response regulatory proteinPseudomonas fluorescens	4
1.10.10.10.139	3cuqB03	Homo sapiensVacuolar protein-sorting-associated protein 36ESCRT-II complex subunit VPS36Endocytosis	2
1.10.10.10.140	2p5vA01	Neisseria meningitidis serogroup BTranscriptional regulator, AsnC familyLrp/AsnC family transcriptional regulator, leucine-responsive regulatory protein	29
1.10.10.10.141	1cf7A00	Protein domain specific bindingE2F transcription factor 4/5Transcription factor bindingTranscription factor E2F4TGF-beta signaling pathway	1
1.10.10.10.142	1k78I00	Paired box protein Pax-5Transcription from RNA polymerase II promoterOrgan morphogenesisPaired box protein 2/5Homo sapiens	4
1.10.10.10.143	2irfG00	Mus musculusInterferon regulatory factor 2Interferon regulatory factor 2	11
1.10.10.10.144	2z3yA01	Oxidoreductases.Lysine-specific histone demethylase 1AHistone demethylase activityNucleusProtein binding	19
1.10.10.10.145	2hr3D02	Probable transcriptional regulatorPseudomonas aeruginosa	4
1.10.10.10.146	1yyvB00	Putative transcriptional regulatorSalmonella enterica subsp. enterica serovar Typhimurium	2
1.10.10.10.147	2w25A01	Lrp/AsnC family transcriptional regulator, leucine-responsive regulatory proteinLeucine-responsive regulatory proteinMycobacterium tuberculosis	24
1.10.10.10.148	1xb4B02	Protein targeting to vacuoleESCRT-II complex subunit VPS25Protein bindingVacuolar protein-sorting-associated protein 25Endocytosis	8
1.10.10.10.149	1b4aA01	Geobacillus stearothermophilusArginine repressor	12
1.10.10.10.150	1bm9A00		17
1.10.10.10.151	2hoeA01	Thermotoga maritimaTranscriptional regulator, XylR-related	1
1.10.10.10.152	1u3eM02	DNA endonuclease I-HmuIBacillus phage SPO1Acting on ester bonds.	1
1.10.10.10.153	2ia0A01	Pyrococcus furiosusUncharacterized HTH-type transcriptional regulator PF0864	2
1.10.10.10.154	2eshA00	Thermotoga maritimaPutative uncharacterized protein	1
1.10.10.10.155	2a6hF02	Thermus thermophilus HB8RNA polymerase sigma factorRNA polymerase primary sigma factor	24
1.10.10.10.156	1ldjA06	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	2
1.10.10.10.157	1pp8O00	39 kDa initiator binding proteinTrichomonas vaginalis	7
1.10.10.10.158	1pdnC02	Transcription activator activitySequence-specific DNA bindingSegmentation protein pairedDrosophila melanogasterPositive regulation of transcription, DNA-dependent	2
1.10.10.10.159	1xd7A00	Bacillus subtilisPutative HTH-type transcriptional regulator ywnA	4
1.10.10.10.160	1fzpD00	Transcriptional regulator sarAStaphylococcus aureus	3
1.10.10.10.161	1ka8A00	Putative P4-specific DNA primaseNucleotidyltransferases.Enterobacteria phage P4	6
1.10.10.10.162	1u5tB01	Protein targeting to vacuoleVacuolar protein-sorting-associated protein 36EndocytosisProtein retention in Golgi apparatusUbiquitin binding	2
1.10.10.10.163	1qo0D02	Pseudomonas aeruginosaAliphatic amidase regulator	2
1.10.10.10.164	2ipqX01	Salmonella enterica subsp. enterica serovar TyphiPutative uncharacterized protein	1
1.10.10.10.165	3fm5A00	Rhodococcus jostii RHA1Transcriptional regulator	4
1.10.10.10.166	1p4xA02	Staphylococcus aureus subsp. aureus NCTC 8325HTH-type transcriptional regulator sarS	1
1.10.10.10.167	3broD00	Oenococcus oeni PSU-1Transcriptional regulator	4
1.10.10.10.168	1ldjA07	Cullin-1Cell cycle arrestInduction of apoptosis by intracellular signalsUbiquitin mediated proteolysisWnt signaling pathway	2
1.10.10.10.169	1gvjA00	Positive regulation of cellular component movementRNA polymerase II transcription factor activityProtein bindingTranscription from RNA polymerase II promoterProtein C-ets-1	5
1.10.10.10.170	1l0oC00	RNA polymerase sigma factorGeobacillus stearothermophilusProtein binding	1
1.10.10.10.171	1p4xA01	Staphylococcus aureus subsp. aureus NCTC 8325HTH-type transcriptional regulator sarS	1
1.10.10.10.172	2a61B00	Thermotoga maritimaTranscriptional regulator, MarR family	4
1.10.10.10.173	2fbhA00	Probable transcriptional regulatorPseudomonas aeruginosaMarR family transcriptional regulator, transcriptional regulator for hemolysin	3
1.10.10.10.174	1lj9B00	Transcriptional regulator, MarR familyEnterococcus faecalis	2
1.10.10.10.175	1ev7B02	Lechevalieria aerocolonigenesType-2 restriction enzyme NaeIType II site-specific deoxyribonuclease.	4
1.10.10.10.176	3bddD00	Streptococcus suis 89/1591Transcriptional regulator, MarR family	4
1.10.10.10.177	2qwwC00	Listeria monocytogenes serotype 4b str. F2365Transcriptional regulator, MarR family	8
1.10.10.10.178	1u5tB02	Protein targeting to vacuoleVacuolar protein-sorting-associated protein 36Negative regulation of transcription from RNA polymerase II promoter by glucoseUbiquitin bindingProtein retention in Golgi apparatus	2
1.10.10.10.179	3cjnA00	Ruegeria pomeroyiTranscriptional regulator, MarR family	1
1.10.10.10.180	1repC01	Replication initiation proteinEscherichia coli K-12	1
1.10.10.10.181	2fbiA00	Probable transcriptional regulatorPseudomonas aeruginosa	1
1.10.10.10.182	3boqA00	Ruegeria pomeroyiTranscriptional regulator, MarR family	2
1.10.10.10.183	2nnnC00	Probable transcriptional regulatorPseudomonas aeruginosa	10
1.10.10.10.184	3bjaA00	Bacillus cereus ATCC 10987Transcriptional regulator, MarR family, putative	1
1.10.10.10.185	2rdpA00	Geobacillus stearothermophilusPutative transcriptional regulator MarR	1
1.10.10.10.186	1hkqA00	Replication proteinPseudomonas syringae	2
1.10.10.10.187	1jgsA00	Multiple antibiotic resistance protein marRMarR family transcriptional regulatorEscherichia coli K-12	1
1.10.10.10.188	3k69A00	Transcription regulator (Putative)Lactobacillus plantarum	1
1.10.10.10.189	3cdhA00	Ruegeria pomeroyiTranscriptional regulator, MarR family	2
1.10.10.10.190	2nyxB01	PROBABLE TRANSCRIPTIONAL REGULATORY PROTEINMycobacterium tuberculosis	4
1.10.10.10.191	3bj6B00	Ruegeria pomeroyiTranscriptional regulator, MarR family	2
1.10.10.10.192	3e6mA00	Ruegeria pomeroyiTranscriptional regulator, MarR family	8
1.10.10.10.193	2zbkA01	DNA topoisomerase (ATP-hydrolyzing).Type II DNA topoisomerase VI subunit ASulfolobus shibatae	4
1.10.10.10.194	2fxaA00	Bacillus subtilisHTH-type transcriptional regulator hprMarR family transcriptional regulator, protease production regulatory protein HPr	4
1.10.10.10.195	1o7fA02	Ras guanyl-nucleotide exchange factor activityCAMP-mediated signalingCytosolRas GTPase bindingMus musculus	1
1.10.10.10.196	1p6rA00	Bacillus licheniformisPenicillinase repressor	2
1.10.10.10.197	1ufmA00	COP9 signalosome complex subunit 4Mus musculusProtein bindingSignalosome	1
1.10.10.10.198	2oa4A01	Ruegeria pomeroyiPutative uncharacterized protein	2
1.10.10.10.199	1d8jA00	Transcription initiation factor IIE subunit betaTranscription initiation factor TFIIE beta subunitHomo sapiensProtein bindingBasal transcription factors	2
1.10.10.10.200	1p4wA00	Two-component systemErwinia amylovoraRcsB proteinTwo-component system, NarL family, captular synthesis response regulator RcsB	1
1.10.10.10.201	1yqaA00	Histone H1/5Protein bindingDNA bindingRegulation of transcription, DNA-dependentNuclear nucleosome	4
1.10.10.10.202	1aoyA00	Arginine repressorTranscriptional regulator of arginine metabolismPlasmid recombinationEscherichia coli K-12	1
1.10.10.10.203	2hgcA00	Bacillus subtilisUncharacterized protein yjcQ	1
1.10.10.10.204	1tnsA00	TransposaseEnterobacteria phage Mu	4
1.10.10.10.205	1e17A00	Transcription factor bindingNucleusCell cycle arrestForkhead box protein O4Insulin receptor signaling pathway	5
1.10.10.10.206	1fshA00	Neurotransmitter secretionReceptor clusteringCytoplasmic membrane-bounded vesicleSegment polarity protein dishevelled homolog DVL-1Synapse	1
1.10.10.10.207	2jt1A00	PefI proteinSalmonella enterica subsp. enterica serovar Typhimurium	1
1.10.10.10.208	1w4mA00	Soluble fractionInhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathwayHemopoietic progenitor cell differentiationActin cytoskeleton reorganizationRuffle organization	3
1.10.10.10.209	1bbyA00	General RNA polymerase II transcription factor activityGeneral transcription factor IIF subunit 2In phosphorous-containing anhydrides.Homo sapiensTranscription initiation factor TFIIF beta subunit	2
1.10.10.10.210	1dpuA00	DNA-dependent DNA replicationDNA replicationReplication protein A 32 kDa subunitNucleotide excision repairReplication factor A2	2
1.10.10.10.211	2krfA00	Transcriptional regulatory protein comABacillus subtilisTwo-component systemTwo-component system, NarL family, competent response regulator ComA	2
1.10.10.10.212	1j9iA00	Terminase small subunitEnterobacteria phage lambda	2
1.10.10.10.213	2jtvA00	Rhodopseudomonas palustrisPutative uncharacterized protein	1
1.10.10.10.214	1oyiA00	Vaccinia virusDouble-stranded RNA-binding protein	1
1.10.10.10.215	1hksA00	NucleusResponse to heatDrosophila melanogasterProtein bindingPolytene chromosome	2
1.10.10.10.216	1s6lA01	Alkylmercury lyaseEscherichia coliAlkylmercury lyase.	1
1.10.10.10.217	1v3fA00	Mus musculusPleckstrin-2	1

Close Structural Clusters (52)
Distant Structural Clusters (15)

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Close Structural Clusters 1.10.10.10 (< 5Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00001.00010.00010.00010/SSG5/1	1yioA02	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/2	2zbkA01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/3	1u5tB01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/4	1ka8A00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/5	1gvjA00	8	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/6	1hstA00	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/7	1fnnB03	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/8	1in4A02	5	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/9	1l3lA02	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/10	1b4aA01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/11	2gauA02	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/12	1kgsA02	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/13	1repC01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/14	1hksA00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/15	3cuqA03	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/16	1hw1A01	6	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/17	1s6lA01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/18	1ixcA01	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/19	1b6aA02	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/20	2dt5B01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/21	3fm5A00	5	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/22	1pdnC02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/23	1xsvA00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/24	1yg2A01	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/25	2dbbB01	7	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/26	1oyiA00	8	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/27	3cuqA02	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/28	2nnnC00	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/29	2ijlB00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/30	1wrjA02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/31	1o57A01	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/32	1p4xA02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/33	2jtvA00	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/34	1qo0D02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/35	2hztC00	9	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/36	2qvoA00	7	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/37	1ulyA01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/38	1v3fA00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/39	1xd7A00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/40	3ctaA01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/41	2fnaA03	6	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/42	2a61B00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/43	2fb1A02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/44	3cjnA00	5	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/45	3bjaA00	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/46	2ipqX01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/47	1on2A01	5	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/48	2oqgC00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/49	3df8A00	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/50	3dfgA02	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/51	2rkhA01	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSG5/52	1sfuA00	16	FASTA Jalview	FASTA Jalview

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

Distant Structural Clusters 1.10.10.10 (< 9Å)

Summary of "distant" structural clusters found within this level of CATH.
Cluster ID	Example Domain	Domains in Cluster	Structural Alignment (Core)	Structural Alignment (Expanded)
00001.00010.00010.00010/SSGA9/1	1hstA00	6	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/2	2ia1B02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/3	1q1hA00	8	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/4	3c7jA01	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/5	1ulyA01	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/6	3boqA00	6	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/7	3jtgA01	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/8	2fb1A02	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/9	2vooB01	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/10	1t0fA02	4	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/11	2o3fA00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/12	1dp7P00	2	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/13	1fc3B00	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/14	1yqaA00	3	FASTA Jalview	FASTA Jalview
00001.00010.00010.00010/SSGA9/15	1xd7A00	16	FASTA Jalview	FASTA Jalview

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 1.10.10.10 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

Homologous Superfamily: 1.10.10.10

"winged helix" repressor DNA binding domain

Classification Lineage (1.10.10.10)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S35 Family Entries in Homologous Superfamily 1.10.10.10 (217)

What is an Close Structural Cluster?

Close Structural Clusters 1.10.10.10 (< 5Å)

What is a Distant Structural Cluster?

Distant Structural Clusters 1.10.10.10 (< 9Å)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 1.10.10.10 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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