S100 Family: 3.90.226.10.8.3.1.1

Representative domain: 1mj3A01

Classification Lineage (3.90.226.10.8.3.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.90	Alpha-Beta Complex
3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1	Gene3D
3.90.226.10.8
3.90.226.10.8.3
3.90.226.10.8.3.1
3.90.226.10.8.3.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	24

Non-Redundant Representatives (24)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.90.226.10.8.3.1.1 (24)

CATH code	Domain ID	Keywords
3.90.226.10.8.3.1.1.1	1mj3A01	Rattus norvegicus, Butanoate metabolism, Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Enoyl-CoA hydratase., fatty acid beta-oxidation, Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism
3.90.226.10.8.3.1.1.2	1mj3B01	fatty acid beta-oxidation, Enoyl-CoA hydratase., Lysine degradation, Propanoate metabolism, Fatty acid elongation in mitochondria, Butanoate metabolism, Rattus norvegicus, Fatty acid metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Metabolic pathways, Enoyl-CoA hydratase, mitochondrial, Tryptophan metabolism, Limonene and pinene degradation
3.90.226.10.8.3.1.1.3	1mj3C01	Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Rattus norvegicus, Butanoate metabolism, Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Enoyl-CoA hydratase., fatty acid beta-oxidation
3.90.226.10.8.3.1.1.4	1mj3D01	Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria, Butanoate metabolism, Rattus norvegicus, fatty acid beta-oxidation, Enoyl-CoA hydratase., Metabolic pathways, Enoyl-CoA hydratase, mitochondrial, Tryptophan metabolism, Limonene and pinene degradation, Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, enoyl-CoA hydratase [EC:4.2.1.17]
3.90.226.10.8.3.1.1.5	1mj3E01	Metabolic pathways, Enoyl-CoA hydratase, mitochondrial, Tryptophan metabolism, Limonene and pinene degradation, Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria, Butanoate metabolism, Rattus norvegicus, fatty acid beta-oxidation, Enoyl-CoA hydratase.
3.90.226.10.8.3.1.1.6	1mj3F01	Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Rattus norvegicus, Butanoate metabolism, Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Enoyl-CoA hydratase., fatty acid beta-oxidation
3.90.226.10.8.3.1.1.7	1ey3A01	Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Rattus norvegicus, Butanoate metabolism, Fatty acid elongation in mitochondria, Lysine degradation, Propanoate metabolism, Enoyl-CoA hydratase., fatty acid beta-oxidation
3.90.226.10.8.3.1.1.8	1ey3B01	fatty acid beta-oxidation, Enoyl-CoA hydratase., Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Rattus norvegicus, Butanoate metabolism, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Metabolic pathways, Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial
3.90.226.10.8.3.1.1.9	1ey3C01	Enoyl-CoA hydratase., fatty acid beta-oxidation, Rattus norvegicus, Butanoate metabolism, Fatty acid elongation in mitochondria, Lysine degradation, Propanoate metabolism, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways
3.90.226.10.8.3.1.1.10	1ey3D01	enoyl-CoA hydratase [EC:4.2.1.17], Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, Enoyl-CoA hydratase, mitochondrial, Limonene and pinene degradation, Tryptophan metabolism, Metabolic pathways, Enoyl-CoA hydratase., fatty acid beta-oxidation, Butanoate metabolism, Rattus norvegicus, Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation
3.90.226.10.8.3.1.1.11	1ey3E01	Butanoate metabolism, Rattus norvegicus, Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Enoyl-CoA hydratase., fatty acid beta-oxidation, Enoyl-CoA hydratase, mitochondrial, Limonene and pinene degradation, Tryptophan metabolism, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism
3.90.226.10.8.3.1.1.12	1ey3F01	enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, Enoyl-CoA hydratase., fatty acid beta-oxidation, Rattus norvegicus, Butanoate metabolism, Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria
3.90.226.10.8.3.1.1.13	2dubD01	Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Rattus norvegicus, Butanoate metabolism, Lysine degradation, Propanoate metabolism, Fatty acid elongation in mitochondria, Enoyl-CoA hydratase., fatty acid beta-oxidation
3.90.226.10.8.3.1.1.14	2dubE01	fatty acid beta-oxidation, Enoyl-CoA hydratase., Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria, Rattus norvegicus, Butanoate metabolism, beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, enoyl-CoA hydratase [EC:4.2.1.17], Metabolic pathways, Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial
3.90.226.10.8.3.1.1.15	2dubF01	Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Metabolic pathways, Enoyl-CoA hydratase, mitochondrial, Limonene and pinene degradation, Tryptophan metabolism, fatty acid beta-oxidation, Enoyl-CoA hydratase., Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Butanoate metabolism, Rattus norvegicus
3.90.226.10.8.3.1.1.16	2dubA01	Metabolic pathways, Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Lysine degradation, Propanoate metabolism, Fatty acid elongation in mitochondria, Rattus norvegicus, Butanoate metabolism, fatty acid beta-oxidation, Enoyl-CoA hydratase.
3.90.226.10.8.3.1.1.17	2dubB01	Metabolic pathways, Limonene and pinene degradation, Tryptophan metabolism, Enoyl-CoA hydratase, mitochondrial, beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Rattus norvegicus, Butanoate metabolism, fatty acid beta-oxidation, Enoyl-CoA hydratase.
3.90.226.10.8.3.1.1.18	2dubC01	beta-Alanine metabolism, Valine, leucine and isoleucine degradation, Fatty acid metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Metabolic pathways, Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial, fatty acid beta-oxidation, Enoyl-CoA hydratase., Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria, Rattus norvegicus, Butanoate metabolism
3.90.226.10.8.3.1.1.19	1dubA01	Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Rattus norvegicus, Butanoate metabolism, Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria, Enoyl-CoA hydratase., fatty acid beta-oxidation
3.90.226.10.8.3.1.1.20	1dubD01	enoyl-CoA hydratase [EC:4.2.1.17], Fatty acid metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, Enoyl-CoA hydratase, mitochondrial, Limonene and pinene degradation, Tryptophan metabolism, Metabolic pathways, Enoyl-CoA hydratase., fatty acid beta-oxidation, Butanoate metabolism, Rattus norvegicus, Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation
3.90.226.10.8.3.1.1.21	1dubE01	Metabolic pathways, Enoyl-CoA hydratase, mitochondrial, Limonene and pinene degradation, Tryptophan metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Fatty acid elongation in mitochondria, Propanoate metabolism, Lysine degradation, Butanoate metabolism, Rattus norvegicus, fatty acid beta-oxidation, Enoyl-CoA hydratase.
3.90.226.10.8.3.1.1.22	1dubB01	enoyl-CoA hydratase [EC:4.2.1.17], Valine, leucine and isoleucine degradation, Fatty acid metabolism, beta-Alanine metabolism, Enoyl-CoA hydratase, mitochondrial, Limonene and pinene degradation, Tryptophan metabolism, Metabolic pathways, Enoyl-CoA hydratase., fatty acid beta-oxidation, Butanoate metabolism, Rattus norvegicus, Fatty acid elongation in mitochondria, Lysine degradation, Propanoate metabolism
3.90.226.10.8.3.1.1.23	1dubC01	Metabolic pathways, Enoyl-CoA hydratase, mitochondrial, Tryptophan metabolism, Limonene and pinene degradation, Fatty acid metabolism, Valine, leucine and isoleucine degradation, beta-Alanine metabolism, enoyl-CoA hydratase [EC:4.2.1.17], Lysine degradation, Propanoate metabolism, Fatty acid elongation in mitochondria, Butanoate metabolism, Rattus norvegicus, fatty acid beta-oxidation, Enoyl-CoA hydratase.
3.90.226.10.8.3.1.1.24	1dubF01	enoyl-CoA hydratase [EC:4.2.1.17], beta-Alanine metabolism, Fatty acid metabolism, Valine, leucine and isoleucine degradation, Tryptophan metabolism, Limonene and pinene degradation, Enoyl-CoA hydratase, mitochondrial, Metabolic pathways, Enoyl-CoA hydratase., fatty acid beta-oxidation, Rattus norvegicus, Butanoate metabolism, Propanoate metabolism, Lysine degradation, Fatty acid elongation in mitochondria

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.90.226.10.8.3.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.90.226.10.8.3.1.1

Classification Lineage (3.90.226.10.8.3.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.90.226.10.8.3.1.1 (24)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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