S100 Family: 3.65.10.10.1.1.1.1

Representative domain: 1g6sA01

Classification Lineage (3.65.10.10.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.65	Alpha-beta prism
3.65.10	UDP-n-acetylglucosamine1-carboxyvinyl-transferase; Chain
3.65.10.10		Gene3D
3.65.10.10.1
3.65.10.10.1.1
3.65.10.10.1.1.1
3.65.10.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	16

Non-Redundant Representatives (16)
Structural Neighbours ()
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.65.10.10.1.1.1.1 (16)

CATH code	Domain ID	Keywords
3.65.10.10.1.1.1.1.1	1g6sA01	3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase, Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12
3.65.10.10.1.1.1.1.2	1x8rA01	Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, Metabolic pathways, 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase.
3.65.10.10.1.1.1.1.3	2aa9A01	Metabolic pathways, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase.
3.65.10.10.1.1.1.1.4	2qfqA01	3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase, Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, Metabolic pathways
3.65.10.10.1.1.1.1.5	2aayA01	3-phosphoshikimate 1-carboxyvinyltransferase, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways, 3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
3.65.10.10.1.1.1.1.6	2qfsA01	3-phosphoshikimate 1-carboxyvinyltransferase, Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, 3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
3.65.10.10.1.1.1.1.7	2qftA01	3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways
3.65.10.10.1.1.1.1.8	1g6tA01	Metabolic pathways, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase.
3.65.10.10.1.1.1.1.9	2pq9A01	Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase.
3.65.10.10.1.1.1.1.10	2qfuA01	Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, Metabolic pathways, 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase.
3.65.10.10.1.1.1.1.11	1mi4A01	3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways
3.65.10.10.1.1.1.1.12	3fjzA01	3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase., Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, Metabolic pathways, 3-phosphoshikimate 1-carboxyvinyltransferase
3.65.10.10.1.1.1.1.13	3fk0A01	3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase., Metabolic pathways, Phenylalanine, tyrosine and tryptophan biosynthesis, Escherichia coli K-12, 3-phosphoshikimate 1-carboxyvinyltransferase
3.65.10.10.1.1.1.1.14	3fk1A01	Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, Metabolic pathways, 3-phosphoshikimate 1-carboxyvinyltransferase, 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase.
3.65.10.10.1.1.1.1.15	3fjxA01	3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase., Metabolic pathways, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis, 3-phosphoshikimate 1-carboxyvinyltransferase
3.65.10.10.1.1.1.1.16	1x8tA01	3-phosphoshikimate 1-carboxyvinyltransferase., 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19], 3-phosphoshikimate 1-carboxyvinyltransferase, Metabolic pathways, Escherichia coli K-12, Phenylalanine, tyrosine and tryptophan biosynthesis

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

Structural Comparisons for Non-redundant S35 Representatives of 3.65.10.10.1.1.1.1 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

S100 Family: 3.65.10.10.1.1.1.1

Classification Lineage (3.65.10.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.65.10.10.1.1.1.1 (16)

What is a Structural Neighbour?

Structural Comparisons for Non-redundant S35 Representatives of 3.65.10.10.1.1.1.1 ( entries)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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