S100 Family: 3.40.50.2000.2.1.1.1

Representative domain: 2gj4A01

Classification Lineage (3.40.50.2000.2.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.40	3-Layer(aba) Sandwich
3.40.50	Rossmann fold
3.40.50.2000	Glycogen Phosphorylase B;	Gene3D
3.40.50.2000.2
3.40.50.2000.2.1
3.40.50.2000.2.1.1
3.40.50.2000.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	69

Non-Redundant Representatives (69)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.40.50.2000.2.1.1.1 (69)

CATH code	Domain ID	Keywords
3.40.50.2000.2.1.1.1.1	2gj4A01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.2	2qrqA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.3	2qnbA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.4	1xc7A01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.5	2qrhA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.6	2qrgA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.7	2pyiA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.8	2qrpA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.9	1z62A01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.10	2qrmA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.11	3bd7A01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.12	3eboA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.13	2pydA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.14	1xl0A01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.15	1xkxA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.16	2f3uA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.17	2f3pA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.18	3cuvA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.19	2f3qA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.20	2f3sA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.21	2qn3A01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.22	3bcsA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.23	3bdaA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.24	3ebpA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.25	3g2iA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.26	3g2kA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.27	2fetA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.28	2ff5A01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.29	3g2hA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.30	3bd6A01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.31	3cuwA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.32	3bcuA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.33	2g9rA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.34	2g9uA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.35	1xl1A01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.36	2qlmA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.37	3bd8A01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.38	2g9vA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.39	3g2jA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.40	2qlnA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.41	3g2nA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.42	3bcrA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.43	1e1yA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.44	2offA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.45	2gm9A01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.46	3g2lA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.47	3cutA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.48	3cuuA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.49	1axrA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.50	2qn1A01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.51	2amvA01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.52	2g9qA01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.53	1gpyA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.54	3e3lB01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.55	3e3lD01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.56	3e3lA01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.57	3e3lC01	Glycogen phosphorylase, muscle form, Oryctolagus cuniculus, Phosphorylase.
3.40.50.2000.2.1.1.1.58	3e3nC01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.59	1pygB01	Phosphorylase., Glycogen phosphorylase, muscle form, Oryctolagus cuniculus
3.40.50.2000.2.1.1.1.60	3e3nA01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.61	3e3nD01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.62	3e3nG01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.63	3e3nB01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.64	3e3nF01	Phosphorylase., Oryctolagus cuniculus, Glycogen phosphorylase, muscle form
3.40.50.2000.2.1.1.1.65	2qn2A01	Oryctolagus cuniculus, Glycogen phosphorylase, muscle form, Phosphorylase.
3.40.50.2000.2.1.1.1.66	1amv001
3.40.50.2000.2.1.1.1.67	1skc001
3.40.50.2000.2.1.1.1.68	1skd001
3.40.50.2000.2.1.1.1.69	1ske001

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.40.50.2000.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.40.50.2000.2.1.1.1

Classification Lineage (3.40.50.2000.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.40.50.2000.2.1.1.1 (69)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts