S100 Family: 3.30.565.10.2.1.1.1

Representative domain: 2iwxA00

Classification Lineage (3.30.565.10.2.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.565	Heat Shock Protein 90
3.30.565.10		Gene3D
3.30.565.10.2
3.30.565.10.2.1
3.30.565.10.2.1.1
3.30.565.10.2.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	22

Non-Redundant Representatives (22)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.565.10.2.1.1.1 (22)

CATH code	Domain ID	Keywords
3.30.565.10.2.1.1.1.1	2iwxA00	cytoplasm, protein refolding, response to osmotic stress, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae, ATPase activity, coupled, protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG
3.30.565.10.2.1.1.1.2	2brcA00	protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, cytoplasm, response to osmotic stress, protein refolding, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae, ATPase activity, coupled
3.30.565.10.2.1.1.1.3	1ah6A00	ATPase activity, coupled, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae, protein refolding, response to osmotic stress, cytoplasm, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82, 'de novo' protein folding, protein targeting to mitochondrion
3.30.565.10.2.1.1.1.4	1amwA00	protein refolding, response to osmotic stress, cytoplasm, ATPase activity, coupled, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae, 'de novo' protein folding, protein targeting to mitochondrion, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82
3.30.565.10.2.1.1.1.5	2vw5A00	Saccharomyces cerevisiae, proteasome assembly, unfolded protein binding, ATPase activity, coupled, cytoplasm, response to osmotic stress, protein refolding, ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG, protein targeting to mitochondrion, 'de novo' protein folding
3.30.565.10.2.1.1.1.6	2vw5B00	'de novo' protein folding, protein targeting to mitochondrion, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82, protein refolding, response to osmotic stress, cytoplasm, ATPase activity, coupled, Saccharomyces cerevisiae, proteasome assembly, unfolded protein binding
3.30.565.10.2.1.1.1.7	2vw5C00	protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, cytoplasm, response to osmotic stress, protein refolding, Saccharomyces cerevisiae, proteasome assembly, unfolded protein binding, ATPase activity, coupled
3.30.565.10.2.1.1.1.8	2vw5D00	response to osmotic stress, protein refolding, cytoplasm, ATPase activity, coupled, Saccharomyces cerevisiae, unfolded protein binding, proteasome assembly, 'de novo' protein folding, protein targeting to mitochondrion, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82
3.30.565.10.2.1.1.1.9	1am1A00	protein refolding, response to osmotic stress, cytoplasm, ATPase activity, coupled, Saccharomyces cerevisiae, proteasome assembly, unfolded protein binding, 'de novo' protein folding, protein targeting to mitochondrion, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82
3.30.565.10.2.1.1.1.10	2breA00	cytoplasm, response to osmotic stress, protein refolding, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae, ATPase activity, coupled, protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG
3.30.565.10.2.1.1.1.11	2akpA00	protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG, cytoplasm, protein refolding, response to osmotic stress, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae, ATPase activity, coupled
3.30.565.10.2.1.1.1.12	2breB00	ATPase activity, coupled, Saccharomyces cerevisiae, unfolded protein binding, proteasome assembly, response to osmotic stress, protein refolding, cytoplasm, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82, 'de novo' protein folding, protein targeting to mitochondrion
3.30.565.10.2.1.1.1.13	2akpB00	cytoplasm, response to osmotic stress, protein refolding, Saccharomyces cerevisiae, unfolded protein binding, proteasome assembly, ATPase activity, coupled, protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG
3.30.565.10.2.1.1.1.14	1ah8A00	'de novo' protein folding, protein targeting to mitochondrion, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82, response to osmotic stress, protein refolding, cytoplasm, ATPase activity, coupled, unfolded protein binding, proteasome assembly, Saccharomyces cerevisiae
3.30.565.10.2.1.1.1.15	1ah8B00	'de novo' protein folding, protein targeting to mitochondrion, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, ATP-dependent molecular chaperone HSP82, response to osmotic stress, protein refolding, cytoplasm, ATPase activity, coupled, proteasome assembly, unfolded protein binding, Saccharomyces cerevisiae
3.30.565.10.2.1.1.1.16	1us7A00	cytoplasm, response to osmotic stress, protein refolding, Saccharomyces cerevisiae, unfolded protein binding, proteasome assembly, ATPase activity, coupled, protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase
3.30.565.10.2.1.1.1.17	2xd6A00	ATP-dependent molecular chaperone HSP82, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, protein targeting to mitochondrion, 'de novo' protein folding, Saccharomyces cerevisiae, unfolded protein binding, proteasome assembly, ATPase activity, coupled, cytoplasm, protein refolding, response to osmotic stress
3.30.565.10.2.1.1.1.18	2vwcA00	ATP-dependent molecular chaperone HSP82, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase, protein targeting to mitochondrion, 'de novo' protein folding, unfolded protein binding, proteasome assembly, Saccharomyces cerevisiae, ATPase activity, coupled, cytoplasm, protein refolding, response to osmotic stress
3.30.565.10.2.1.1.1.19	1a4hA00	ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG, protein targeting to mitochondrion, 'de novo' protein folding, Saccharomyces cerevisiae, proteasome assembly, unfolded protein binding, ATPase activity, coupled, cytoplasm, response to osmotic stress, protein refolding
3.30.565.10.2.1.1.1.20	2iwsA00	cytoplasm, response to osmotic stress, protein refolding, unfolded protein binding, proteasome assembly, Saccharomyces cerevisiae, ATPase activity, coupled, protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, molecular chaperone HtpG, positive regulation of telomere maintenance via telomerase
3.30.565.10.2.1.1.1.21	2iwuA00	cytoplasm, response to osmotic stress, protein refolding, Saccharomyces cerevisiae, proteasome assembly, unfolded protein binding, ATPase activity, coupled, protein targeting to mitochondrion, 'de novo' protein folding, ATP-dependent molecular chaperone HSP82, positive regulation of telomere maintenance via telomerase, molecular chaperone HtpG
3.30.565.10.2.1.1.1.22	2vlsA00

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.565.10.2.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.565.10.2.1.1.1

Classification Lineage (3.30.565.10.2.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.565.10.2.1.1.1 (22)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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