S100 Family: 3.30.200.20.2.1.2.1

Representative domain: 2a2aB01

Classification Lineage (3.30.200.20.2.1.2.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.30	2-Layer Sandwich
3.30.200	Phosphorylase Kinase; domain 1
3.30.200.20	Phosphorylase Kinase; domain 1	Gene3D
3.30.200.20.2
3.30.200.20.2.1
3.30.200.20.2.1.2
3.30.200.20.2.1.2.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	27

Non-Redundant Representatives (27)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.30.200.20.2.1.2.1 (27)

CATH code	Domain ID	Keywords
3.30.200.20.2.1.2.1.1	2a2aB01	calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Pathways in cancer, Bladder cancer, Homo sapiens, induction of apoptosis, cytoplasm, intracellular protein kinase cascade, Death-associated protein kinase 2, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding
3.30.200.20.2.1.2.1.2	2a2aC01	induction of apoptosis, cytoplasm, intracellular protein kinase cascade, Death-associated protein kinase 2, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding, Pathways in cancer, calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Bladder cancer, Homo sapiens
3.30.200.20.2.1.2.1.3	2a2aD01	Homo sapiens, Bladder cancer, Pathways in cancer, Non-specific serine/threonine protein kinase., calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, Death-associated protein kinase 2, intracellular protein kinase cascade, induction of apoptosis, cytoplasm
3.30.200.20.2.1.2.1.4	2a2aA01	Pathways in cancer, calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Bladder cancer, Homo sapiens, induction of apoptosis, cytoplasm, intracellular protein kinase cascade, Death-associated protein kinase 2, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding
3.30.200.20.2.1.2.1.5	2ckeB01	induction of apoptosis, cytoplasm, Death-associated protein kinase 2, intracellular protein kinase cascade, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding, Pathways in cancer, Bladder cancer, Homo sapiens
3.30.200.20.2.1.2.1.6	2ckeC01	identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, intracellular protein kinase cascade, Death-associated protein kinase 2, cytoplasm, induction of apoptosis, Homo sapiens, Bladder cancer, Pathways in cancer, calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity
3.30.200.20.2.1.2.1.7	2ckeD01	Bladder cancer, Homo sapiens, calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Pathways in cancer, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding, induction of apoptosis, cytoplasm, intracellular protein kinase cascade, Death-associated protein kinase 2
3.30.200.20.2.1.2.1.8	2ckeA01	Pathways in cancer, Non-specific serine/threonine protein kinase., calmodulin binding, calmodulin-dependent protein kinase activity, Homo sapiens, Bladder cancer, Death-associated protein kinase 2, intracellular protein kinase cascade, induction of apoptosis, cytoplasm, identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation
3.30.200.20.2.1.2.1.9	2a27B01	identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, Death-associated protein kinase 2, intracellular protein kinase cascade, cytoplasm, induction of apoptosis, Homo sapiens, Bladder cancer, Pathways in cancer, Non-specific serine/threonine protein kinase., calmodulin binding, calmodulin-dependent protein kinase activity
3.30.200.20.2.1.2.1.10	2a27C01	cytoplasm, induction of apoptosis, intracellular protein kinase cascade, Death-associated protein kinase 2, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding, Pathways in cancer, calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Bladder cancer, Homo sapiens
3.30.200.20.2.1.2.1.11	2a27E01	intracellular protein kinase cascade, Death-associated protein kinase 2, induction of apoptosis, cytoplasm, identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity, Pathways in cancer, Homo sapiens, Bladder cancer
3.30.200.20.2.1.2.1.12	2a27F01	Pathways in cancer, calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity, Homo sapiens, Bladder cancer, intracellular protein kinase cascade, Death-associated protein kinase 2, induction of apoptosis, cytoplasm, identical protein binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding
3.30.200.20.2.1.2.1.13	2a27G01	Death-associated protein kinase 2, intracellular protein kinase cascade, induction of apoptosis, cytoplasm, identical protein binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, Non-specific serine/threonine protein kinase., calmodulin binding, calmodulin-dependent protein kinase activity, Pathways in cancer, Homo sapiens, Bladder cancer
3.30.200.20.2.1.2.1.14	2a27A01	Pathways in cancer, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding, Bladder cancer, Homo sapiens, induction of apoptosis, cytoplasm, Death-associated protein kinase 2, intracellular protein kinase cascade, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding
3.30.200.20.2.1.2.1.15	2a27D01	protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding, cytoplasm, induction of apoptosis, Death-associated protein kinase 2, intracellular protein kinase cascade, Bladder cancer, Homo sapiens, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding, Pathways in cancer
3.30.200.20.2.1.2.1.16	2a27H01	Bladder cancer, Homo sapiens, Pathways in cancer, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding, cytoplasm, induction of apoptosis, Death-associated protein kinase 2, intracellular protein kinase cascade
3.30.200.20.2.1.2.1.17	1wmkC01	cytoplasm, induction of apoptosis, Death-associated protein kinase 2, intracellular protein kinase cascade, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding, Pathways in cancer, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding, Bladder cancer, Homo sapiens
3.30.200.20.2.1.2.1.18	1wmkF01	Bladder cancer, Homo sapiens, Pathways in cancer, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding, induction of apoptosis, cytoplasm, Death-associated protein kinase 2, intracellular protein kinase cascade
3.30.200.20.2.1.2.1.19	1wmkA01	death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding, cytoplasm, induction of apoptosis, Death-associated protein kinase 2, intracellular protein kinase cascade, Bladder cancer, Homo sapiens, Pathways in cancer, calmodulin-dependent protein kinase activity, Non-specific serine/threonine protein kinase., calmodulin binding
3.30.200.20.2.1.2.1.20	1wmkB01	Homo sapiens, Bladder cancer, calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity, Pathways in cancer, identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, intracellular protein kinase cascade, Death-associated protein kinase 2, induction of apoptosis, cytoplasm
3.30.200.20.2.1.2.1.21	1wmkD01	calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity, Pathways in cancer, Homo sapiens, Bladder cancer, intracellular protein kinase cascade, Death-associated protein kinase 2, cytoplasm, induction of apoptosis, identical protein binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding
3.30.200.20.2.1.2.1.22	1wmkE01	Homo sapiens, Bladder cancer, Non-specific serine/threonine protein kinase., calmodulin binding, calmodulin-dependent protein kinase activity, Pathways in cancer, identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, Death-associated protein kinase 2, intracellular protein kinase cascade, induction of apoptosis, cytoplasm
3.30.200.20.2.1.2.1.23	1wmkG01	cytoplasm, induction of apoptosis, intracellular protein kinase cascade, Death-associated protein kinase 2, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation, identical protein binding, calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Pathways in cancer, Bladder cancer, Homo sapiens
3.30.200.20.2.1.2.1.24	1wmkH01	cytoplasm, induction of apoptosis, intracellular protein kinase cascade, Death-associated protein kinase 2, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, identical protein binding, Pathways in cancer, calmodulin-dependent protein kinase activity, calmodulin binding, Non-specific serine/threonine protein kinase., Bladder cancer, Homo sapiens
3.30.200.20.2.1.2.1.25	1z9xA01	Homo sapiens, Bladder cancer, Non-specific serine/threonine protein kinase., calmodulin binding, calmodulin-dependent protein kinase activity, Pathways in cancer, identical protein binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, Death-associated protein kinase 2, intracellular protein kinase cascade, cytoplasm, induction of apoptosis
3.30.200.20.2.1.2.1.26	1z9xB01	intracellular protein kinase cascade, Death-associated protein kinase 2, cytoplasm, induction of apoptosis, identical protein binding, protein phosphorylation, death-associated protein kinase [EC:2.7.11.1], ATP binding, Pathways in cancer, calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity, Homo sapiens, Bladder cancer
3.30.200.20.2.1.2.1.27	1z9xC01	Pathways in cancer, calmodulin binding, Non-specific serine/threonine protein kinase., calmodulin-dependent protein kinase activity, Homo sapiens, Bladder cancer, intracellular protein kinase cascade, Death-associated protein kinase 2, induction of apoptosis, cytoplasm, identical protein binding, death-associated protein kinase [EC:2.7.11.1], ATP binding, protein phosphorylation

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.30.200.20.2.1.2.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.30.200.20.2.1.2.1

Classification Lineage (3.30.200.20.2.1.2.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.30.200.20.2.1.2.1 (27)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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