S100 Family: 3.100.10.10.1.1.1.1

Representative domain: 1vq8O00

Classification Lineage (3.100.10.10.1.1.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.100	Ribosomal Protein L15; Chain: K; domain 2
3.100.10	Ribosomal Protein L15; Chain: K; domain 2
3.100.10.10		Gene3D
3.100.10.10.1
3.100.10.10.1.1
3.100.10.10.1.1.1
3.100.10.10.1.1.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	64

Non-Redundant Representatives (64)
Functional Families
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What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.100.10.10.1.1.1.1 (64)

CATH code	Domain ID	Keywords
3.100.10.10.1.1.1.1.1	1vq8O00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.2	1vqoO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.3	1vqpO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.4	1vqkO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.5	1vqlO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.6	1vqmO00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.7	1jj2N00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.8	1s72O00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.9	1vq9O00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.10	1vqnO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.11	1yhqO00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.12	3cc2O00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.13	1vq7O00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.14	3ccmO00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.15	1vq5O00	50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.16	1yijO00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.17	1yi2O00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.18	1vq4O00	Ribosome, 50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.19	1vq6O00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.20	2otlO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.21	3cc4O00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.22	3cc7O00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.23	3ccjO00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.24	3cpwN00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.25	3g6eO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.26	3cceO00	Ribosome, 50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.27	3cd6O00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.28	1m90P00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.29	1yitO00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.30	3ccuO00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.31	3cmaO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.32	3g71O00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.33	1qvgN00	Ribosome, large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e
3.100.10.10.1.1.1.1.34	1yj9O00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.35	1yjwO00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.36	2otjO00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.37	2qexO00	Ribosome, 50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.38	3cclO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.39	3ccqO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.40	3ccvO00	Ribosome, 50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.41	3i56O00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.42	1q81P00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.43	3ccsO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.44	3cmeO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.45	1q82P00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.46	1k8aP00	50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.47	1k9mP00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.48	1kd1P00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.49	1n8rP00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.50	1njiP00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.51	1q86P00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.52	1yjnO00	50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.53	2qa4O00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.54	3ccrO00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.55	3cxcN00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.56	1k73P00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.57	1kc8P00	50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.58	1kqsN00	large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui, Ribosome
3.100.10.10.1.1.1.1.59	1qvfN00	Ribosome, large subunit ribosomal protein L18e, 50S ribosomal protein L18e, Haloarcula marismortui
3.100.10.10.1.1.1.1.60	3i55O00	Ribosome, Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e
3.100.10.10.1.1.1.1.61	1m1kP00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.62	1q7yP00	large subunit ribosomal protein L18e, Haloarcula marismortui, 50S ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.63	3g4sO00	Haloarcula marismortui, 50S ribosomal protein L18e, large subunit ribosomal protein L18e, Ribosome
3.100.10.10.1.1.1.1.64	1w2bN00	Ribosome, 50S ribosomal protein L18e, Haloarcula marismortui, large subunit ribosomal protein L18e

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.100.10.10.1.1.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.100.10.10.1.1.1.1

Classification Lineage (3.100.10.10.1.1.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.100.10.10.1.1.1.1 (64)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

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