S100 Family: 3.10.450.40.9.2.1.1

Representative domain: 2c10A01

Classification Lineage (3.10.450.40.9.2.1.1)

CATH Code	Level Description	Links
3	Alpha Beta
3.10	Roll
3.10.450	Nuclear Transport Factor 2; Chain: A,
3.10.450.40		Gene3D
3.10.450.40.9
3.10.450.40.9.2
3.10.450.40.9.2.1
3.10.450.40.9.2.1.1

Summary of Non-Redundant Representatives


-	-	-	-	-	-	-	-	6

Non-Redundant Representatives (6)
Functional Families
Help

What is a Non-Redundant Representative?

CATH is a tree-like organisation of nodes that begins with the class node (i.e. the first branch-point of the tree) and ends with the domain nodes (i.e. the leaves of the tree). Each node below the class have a parent that they belong to, e.g. the parent of the H level (Homologous superfamily) is the T (Topology). Additionally, each node above the domains have child nodes that belong to them, e.g. the child nodes of a given H (Homologous superfamily) level are the S35 families (domains clustered at > 35% sequence identity).

S100 Count Entries in S100 Family 3.10.450.40.9.2.1.1 (6)

CATH code	Domain ID	Keywords
3.10.450.40.9.2.1.1.1	2c10A01	amine metabolic process, inflammatory response, cell surface, primary-amine oxidase [EC:1.4.3.21], plasma membrane, Phenylalanine metabolism, Primary-amine oxidase., Tyrosine metabolism, Glycine, serine and threonine metabolism, Membrane primary amine oxidase, cell adhesion, protein homodimerization activity, Metabolic pathways, integral to membrane, primary amine oxidase activity, copper ion binding, quinone binding, beta-Alanine metabolism, Homo sapiens
3.10.450.40.9.2.1.1.2	2c10C01	integral to membrane, primary amine oxidase activity, Tyrosine metabolism, Glycine, serine and threonine metabolism, Membrane primary amine oxidase, protein homodimerization activity, cell adhesion, Metabolic pathways, quinone binding, copper ion binding, beta-Alanine metabolism, Homo sapiens, inflammatory response, cell surface, primary-amine oxidase [EC:1.4.3.21], amine metabolic process, plasma membrane, Phenylalanine metabolism, Primary-amine oxidase.
3.10.450.40.9.2.1.1.3	2c10B01	amine metabolic process, inflammatory response, cell surface, primary-amine oxidase [EC:1.4.3.21], plasma membrane, Phenylalanine metabolism, Primary-amine oxidase., Glycine, serine and threonine metabolism, Tyrosine metabolism, Membrane primary amine oxidase, cell adhesion, protein homodimerization activity, Metabolic pathways, integral to membrane, primary amine oxidase activity, copper ion binding, quinone binding, beta-Alanine metabolism, Homo sapiens
3.10.450.40.9.2.1.1.4	2c10D01	beta-Alanine metabolism, Homo sapiens, quinone binding, copper ion binding, protein homodimerization activity, cell adhesion, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Membrane primary amine oxidase, integral to membrane, primary amine oxidase activity, Phenylalanine metabolism, Primary-amine oxidase., plasma membrane, amine metabolic process, cell surface, primary-amine oxidase [EC:1.4.3.21], inflammatory response
3.10.450.40.9.2.1.1.5	1us1A01	Tyrosine metabolism, Glycine, serine and threonine metabolism, Membrane primary amine oxidase, Metabolic pathways, cell adhesion, protein homodimerization activity, primary amine oxidase activity, integral to membrane, copper ion binding, quinone binding, Homo sapiens, beta-Alanine metabolism, amine metabolic process, inflammatory response, primary-amine oxidase [EC:1.4.3.21], cell surface, plasma membrane, Primary-amine oxidase., Phenylalanine metabolism
3.10.450.40.9.2.1.1.6	1pu4A01	protein homodimerization activity, cell adhesion, Metabolic pathways, Tyrosine metabolism, Glycine, serine and threonine metabolism, Membrane primary amine oxidase, integral to membrane, primary amine oxidase activity, beta-Alanine metabolism, Homo sapiens, quinone binding, copper ion binding, amine metabolic process, cell surface, primary-amine oxidase [EC:1.4.3.21], inflammatory response, Phenylalanine metabolism, Primary-amine oxidase., plasma membrane

The information on Functional Families (FunFams) is currently being updated and will be released by the end of March 2012. The pages will include the following features:

Multiple alignments for each functional family
Representative structure for each functional with known catalytic and interface residues highlighted, along with conserved residues predicted by scorecons
Detailed functional information on diversity and conservation within Functional families
Multi-domain architectures

In the meantime, please find a summary of information on the FunFams and protein networks within this superfamily on the Gene3D pages:

http://gene3d.biochem.ucl.ac.uk/superfamily/?accession=3.10.450.40.9.2.1.1

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

The simple answer is that some of the larger superfamilies in CATH comprise relatives which are very structurally diverse, having different secondary structure embellishments. Attempting to provide a global alignment of all domains in the superfamily would result in poor quality alignments. As a result, structural alignments in CATH are generated by first clustering together the structures that have at least some recognisable structural similarity using a normalised RMSD score (SIMAX = RMSDxNumber of residues in the largest domain/number of aligned residues) less than a given cutoff.

What is an Close Structural Cluster?

A Close Structural Cluster describes a cluster of two or more CATH domains that have been grouped together due to their close structural similarity (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Distant Structural Cluster?

A Distant Structural Cluster describes a cluster of two or CATH domains that have been grouped together with a more relaxed structural similarity threshold to investigate more distant evolutionary similarities (SIMAX score < 5Å where SIMAX = RMSD x Number of residues in the larger domain/number of aligned residues).

What is a Structural Neighbour?

The term "structural neighbour" is used here to describe two CATH domains that share a degree of structural similarity. The SSAP algorithm is used to calculate this similarity and works by generating a structure-based pairwise alignment of the two domains then scoring this alignment using a RMSD score which has been normalised by the length of the larger domain divided by the number of aligned residues (SIMAX).

S100 Family: 3.10.450.40.9.2.1.1

Classification Lineage (3.10.450.40.9.2.1.1)

Summary of Non-Redundant Representatives

What is a Non-Redundant Representative?

S100 Count Entries in S100 Family 3.10.450.40.9.2.1.1 (6)

What is a Non-Redundant Representative?

Why can't I have a multiple structural alignment of the whole superfamily?

What is an Close Structural Cluster?

What is a Distant Structural Cluster?

What is a Structural Neighbour?

CATH Shortcuts